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🩸🧠User friendly version of Boston Criteria v2.0 for Sporadic Cerebral Amyloid Angiopathy (CAA) #NeuroTwitter #Neurology #Neurosurgery #stroke #MedStudentTwitter #FOAMncc #MedTwitter #amyloidangiopathy #FOAMncc #neuroscience #brain #Alzheimers #Alzheimer #illustration

Optimised medical therapy alone versus optimised medical therapy plus revascularisation for asymptomatic or low-to-intermediate risk symptomatic carotid stenosis (ECST-2): 2-year interim results of a multicentre randomised trial - The Lancet Neurology thelancet.com/journals/laneu…

LAAO and stroke: We summarize current evidence & ongoing trials: promising option for AF patients to avoid OAC (i.e. after ICH, CAA) or if DOAC alone is not enough (i.e. after #breakthroughstroke) Alexander Benz ⁦ELAPSE⁩ ⁦Stroke AHA/ASA⁩ ahajournals.org/doi/10.1161/ST…

Effect of intravenous alteplase before endovascular therapy for atherothrombotic stroke-related large vessel occlusion: subanalysis of the RESCUE AT-LVO registry svn.bmj.com/content/early/…

The ICH-ADAPT2 trial results were just published in JAMA Neurology. DWI lesions are observed in ~33% of patients with acute ICH. Our findings do not support a causal relationship between intensive BP lowering and DWI lesions in these patients. jamanetwork.com/journals/jaman… PHRI.ca Population Health Research Institute 🇨🇦

Intraluminal thrombi are seen in about 2-5% of patients with ischemic stroke and are associated with increased risk of recurrence and surgical complication. Most are related to underlying atherosclerosis but it can also be seen in dissection, webs, and hypercoagulable disorders.

Our ANNEXa-I biomarker substudy results were just published in Stroke AHA/ASA and provide additional insights into the mechanism of action of andexanet alfa (AA) in patients with FXaI-associated ICH. ahajournals.org/doi/10.1161/ST… 🧵 1/3

🚨 Cherry picking of patients can be a major problem in acute stroke trials. Mayank Goyal and I discuss factors contributing to cherry picking (such as the What's In It For Us [WIIFU] problem) + how we might measure and mitigate it: ahajournals.org/doi/10.1161/ST… DCNS Calgary Stroke AHA/ASA

One of my favourite topics to discuss with trainees. Overprescribing of statins in stroke patients and who really needs it and benefits. ahajournals.org/doi/full/10.11…

I was thrilled to give this talk on an important rare CNS inflammatory condition I see relatively frequently in my practice at Unity Health Toronto SMHNeurology - neurosarcoidosis. A true clinical chameleon, it demands vigilance, early recognition, & collaboration across specialties.

Great article on 3D maps of the LSA territory stroke. First-order (especially when multiple) LSA territory stroke should raise suspicion of ICAD! neurology.org/doi/10.1212/WN…

Presented at #ESOC2025: Among 550 patients with stroke due to large-vessel occlusion who had presented within 4.5 hours after onset, 90-day functional outcomes were better with intravenous tenecteplase before thrombectomy than with thrombectomy alone. Read the full BRIDGE-TNK

New ESCAPE-MeVO data show collateral status on CTA & time since symptom onset-not occlusion site or vessel size -was linked to 90-day outcome in MeVO stroke. Only collaterals and time predicted EVT benefit. A step toward better selection for reperfusion. #ESOC2025 #VoiceOfStroke

What if I told you it is possible to increase 6⃣ times the detection of cardioaortic thrombi in stroke patients with a simple tweak to your current workflow? 🤯🤯🤯 We would only need to screen 1⃣4⃣ patients to find 1⃣ thrombus! Curious? Read on! DAYLIGHT Trial

Predicting Alzheimer's in people who are cognitively unimpaired in middle-age via blood tests p-tau217 did well (best single biomarker), its ratio with Aβ42 had highest performance for detecting PET + amyloid new publication today thelancet.com/journals/ebiom…

Every 10 mg/dL ⬇️ in LDL for patients with ICAD stroke has 9% ⬇️ rates of recurrent stroke or MI. this theoretical framework suggests that PCSK9i can help achieve this. We need PCSK-9i trials in ICAD Jim Siegler (@jimsieglermd.bsky.social now) Tareq Kass-Hout Malik Ghannam Seemant Chaturvedi neurology.org/doi/10.1212/WN…

Our meta-analysis comparing intracranial hemorrhage risks w/ ASA vs apix, now online @ Stroke. Contrary to common perceptions, we found no evidence in the ischemic stroke prevention setting that apix confers higher intracranial bleeding risk vs ASA. ahajournals.org/doi/10.1161/ST…

NEW PAPER is out! We measured plasma p-tau217 and Aβ42/40 in 509 patients with the cognitive concerns. Worth a read if you're thinking of using blood-based biomarkers in the outpatient clinic. doi.org/10.1002/alz.70… Yoav Piura Mayo Clinic Mayo Clinic Neuro Mayo Clinic Labs

📚🧠5 Essential Neurology Books (Residency basics) 1. Clinical Neurology & Neuroanatomy Aaron Berkowitz 2. How to think like a neurologist Ethan Meltzer, MD 3. The Acute Neurology Survival Guide Casey Albin, MD 4. The Code Stroke Handbook Andrew Micieli 5. Brainspotting Andrew Lees

Hot off the press, carotid revascularization may be superior to medical treatment in patients with symptomatic carotid artery webs. Excited to start the multicenter SPIDER-WEB study which will provide more insight on this issue. #stroke #annalsofneurology onlinelibrary.wiley.com/doi/10.1002/an…