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"Natural selection picks the wheat from the chaff and guides mutating proteins along continuously functional paths through the vast space of sequences mostly devoid of function." Frances Arnold nobelprize.org/uploads/2018/1…

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1/ 🧵Thrilled to share our most recent work on the structure of the activated helper NLR NRC2! In addition to Madhu's thread, here is our AlphaFold (AF) structural modelling of the inflammasome-like resistosome. Can we predict large structure stoichiometries? Tune in!

I filmed the microscopic explosions that allow sperm release and fertilization in flowering plants at the highest resolution to date and in 3D 💥(biorxiv.org/content/10.110…) Don’t have time to read? Just watch the movies in this thread 🧵

Today we wish Clinton well as moves on to start a PhD with Hiro Nakagami 中神 弘史 MPIPZ Cologne. After graduating from our MSc in Global Plant Health, he spent a very productive year as a pre-doctoral intern with TSL Proteomics Frank Menke

Great The Sainsbury Laboratory fun day Holkham. Teambuilding games #TeamButterfly Joe Win @CamilaMolinari3 @markjoules Sarah Pottinger @michealagdobo AmirAli Toghani and touring estate in great company Dr. Wenbo Ma Jonathan D G Jones

It has been a wonderful year of learning, unlearning, and meeting amazing people. I am truly grateful for these experiences.

It was a pleasure to host Salaudeen Salaudeen Bandanaa in the lab this summer for his MSc project. Salaudeen worked on parasitic nematode effectors with Daniel Daniel Lüdke

To advertise submissions for the #ICAR 2025 movie, I will be posting the coolest Arabidopsis live imaging with an artistic spin. Let's start with these awesome videos of mitochondrial movements by Joanna Chustecki. Thank you for sharing!

Nothing better than giving special people in the lab a little Eppendorf bouquet of special flowers :)

Excited to start a new adventure in The Sainsbury Laboratory with Dr. Wenbo Ma, after a great time as a predoc with Jonathan D G Jones Frank Menke . Grateful for this opportunity to keep learning and doing great science in the MPMI field ❤️ #TSLatins

Welcome to the The Sainsbury Laboratory Proteomics team to our October starters Markus Draeger and Michael Agbodo. New Postdoc and Predoc respectively.

That’s a wrap for this year’s The Sainsbury Laboratory and John Innes Centre Annual Science Meeting. Great talks, excellent discussions, 69 posters and full house throughout. Big thanks to my co-organizing colleagues.

Molecular dynamics simulations in mixed reality! With Luciano Abriata and Lucien Krapp we’re scaling our multi-user WebXR platform to enable immersive molecular simulations, fully based on web technologies. Stay tuned, lots of cool stuff coming soon! Three.js #WebXR #Quest3

Death of a flower ☠️🌹 Without ventilation, my flowers' petals crumple and abscise, likely due to ethylene buildup in the timelapse box. It is interesting how the flower behavior reflects the plants health and can evoke emotion.

One-year taught MSc in Global Plant Health. Apply now for 22 September 2025 entry. Scholarships available. Learn from Nick Talbot Jonathan D G Jones Sophien Kamoun Dr. Wenbo Ma Tatsuya Nobori @kamiljwitek Frank Menke Cyril Zipfel, Dan MacLean & guests. tsl.ac.uk/msc @BioUEA

Huge congratulations to Markus Draeger for successfully defending his PhD thesis. Thanks go out to the examiners @JSC_Cellsensing and Saskia Hogenhout and Markus's supervisor Frank Menke

A predoc - suitable for someone considering a PhD or a highly motivated 'year-in-industry' undergraduate tsl.ac.uk/working-at-tsl… 4/5

Welcome to Hazel Surtees who joins the The Sainsbury Laboratory #Proteomics team on her second rotation to investigate PSK-induced changes to Arabidopsis proteome with Markus Draeger

A true “lab” story in full bloom: Jonathan D. G. Jones, Wolf Prize Laureate in Agriculture 2025, and Caroline Dean, Wolf Prize Laureate in Agriculture 2020, are more than just partners in life — they’re also partners in discovery. Jonathan’s pioneering work revealed how plants