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Excited to share our biochemical reconstitution of the human gamma-TuRC! : biorxiv.org/content/10.110…

This is what we dreamed of 25 years ago when it became clear that gamma-tubulin was in a large complex. Now here in a preprint from Michal Wieczorek: reconstitution of the gamma-TuRC from expressed components! biorxiv.org/content/10.110…

Biochemical reconstitutions reveal principles of human gamma-tubulin ring complex (γ-TuRC) assembly and function. A report from Wieczorek (Michal Wieczorek), Tarun M. Kapoor Rockefeller University and colleagues: bit.ly/3a4hFRb #Biochemistry #Cytoskeleton #StructuralBiology

Our March cover image shows a montage of 2D class averages of a reconstituted human γ-tubulin ring complex (γ-TuRC) imaged using transmission EM. From a report by Michal Wieczorek et al. (bit.ly/3aetuWn). Read the JCB March 2021 Issue: bit.ly/3dDeKlY

We have a Research Assistant position available (details below): please RT / spread the word!

With the new academic year starting, and many people beginning fresh as graduate students, post-docs, or junior faculty, I have been thinking a lot about the core philosophies that govern my own perspectives on science. So I thought I would share. Welcome to The Tao of Cheese

Fantastic work from my lab mate Keith J. Mickolajczyk : catch-bonding by a dynein-like AAA protein involved in ribosome biogenesis

Bacteria can be pirates too... 🏴‍☠️ Let us introduce you to Captain Aureispira ⛵️ A bacterial pirate ship loaded with canons 💉 and grappling hooks 🪝🌴predating on other bacteria 🦠 Check the preprint: biorxiv.org/content/10.110… #predation #T6SS #T9SS #cryoEM #cryoET #teamtomo 🧵1/6

The gamma-tubulin ring complex controls microtubule nucleation in cells. The Michal Wieczorek lab demonstrates that CDK5RAP2 regulates the structure of the gamma-tubulin ring complex to dramatically promote its microtubule-nucleating activity. More: biol.ethz.ch/en/news-and-ev…

I am excited to share our latest work on creating the first tunable Catch-Bond with #DNA! Our Fish-Hook architecture allowed precise control of adhesion nanomechanics, creating new possibilities for bioengineering and material science! 🧬🐟🪝🌟nature.com/articles/s4146… #biophysics

Captain Aureispira - a bacterial pirate ship🦜🏴‍☠️🪝- boarded Science Magazine. Check out the manuscript here: science.org/doi/10.1126/sc… and have a look on our extended thread below ⬇️We provide new insights on bacterial predation from molecules ⚛️to ocean samples 🌊

Phosphorylation can regulate protein function via diverse mechanisms, including the regulation of protein conformations. In our new preprint @[email protected] compared structures of the same proteins and protein familes in phospho and non phosphorylated forms biorxiv.org/content/10.110…

rdcu.be/dY5rl The latest research article from Ti Lab. We employed cryo-EM structural analysis, single-particle fluorescence microscopy, and recombinant tubulin to reveal how tubulin acetyltransferases modify the K40 residue inside the microtubule lumen. (1/N)

Lab’s first paper is out 🥳🍾! We reveal how tubulins regulate the stability of their mRNAs via reversible sequestration of TTC5. Bravo A. Batiuk and all coauthors! Markus Höpfler Ana Almeida Lila Oscar UNIGE_en Nature Communications 👇 doi.org/10.1038/s41467…

I knew it wouldn't be long before we see structures of a #phage cousin infecting #Archea 🦠 Beautiful structures from Bertram Daum, congrats!

Proud to see our work on how NEDD1 binds to the γ-TuRC finally published! Great collaboration with the Kapoor Lab - congratulations to all the authors involved! rupress.org/jcb/article/22…