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🔥HOT OFF THE PRESS Nature Genetics from Maciej Tomaszewski and colleagues: Uncovering genetic mechanisms of hypertension through multi-omic analysis of the kidney Read it here👇👇 go.nature.com/2PUgDB9

Whole-exome imputation, next trend before widespread WGS?

I'm thrilled to share a big update to AstraZeneca PheWAS Portal azphewas.com published in nature tinyurl.com/3te5hdby. Major improvements are 1) expanded dataset calculated now on ~450K UK Biobank participant exomes: >40k significant gene or variant associations!

Centre for Genomics Research AstraZeneca are looking for a #postdoc to use big data from UK Biobank Genomics England & FinnGen to understand neurodegenerative disease and find new drug targets! tinyurl.com/v4c9b58m #ScienceJobs #AcademicChatter #pharmajobs #postdocjobs

Thrilled to share our work on fine-mapping of immune-mediated diseases (IMD) using regulatory quantitative trait loci (QTLs) finally out in Nature Genetics nature.com/articles/s4158… Soranzo Lab @ Wellcome Sanger Institute Wellcome Sanger Institute Cambridge University #immunediseases #autoimmune #GWAS #QTL 🧵 1/14

Our review of kidney-omics in hypertension is out. We cover genomics, transcriptomics, single-cell, epigenomics, integrative stats, causality, clinical implications and new drugs. kidney-international.org/article/S0085-… Joanna Howson @NoraFranceschi2 CVR Tomasz Guzik Ben Humphreys Fadi Charchar

🎇Our massive effort to define genes and cells causing kidney disease published Nature Genetics by Hongbo Liu New GWAS in 1.5 million, kidney eQTL in 686, meQTL 443, snATACseq 60K cells, coloc, moloc, MR, pheWAS to prioritize >500 genes for kidney disease go.nature.com/3tHf9Lj

Our pre-print describing the UK Biobank Pharma Proteomics Project (UKB-PPP) is now online! biorxiv.org/content/10.110… We identify 10k+ genetic associations w/ protein concentrations; 85% are new. The data should help drive discovery of new biomarkers, diagnostics & medicines.

I will present on “Assessing the underrepresentation of diversity in evaluating CYP2D6 genotypes: a study of 490,558 genomes in the UK Biobank”. Time: 8:30-45 AM 11/2/2023 ET Room: Conv Ctr/Room 147A/Level 1 #ASHG2023 #UKBiobank #Pharmacogenomics

Interested in a PhD studying multimorbidity using multi-omics data? Studying BHF Cardiovascular Epidemiology Unit at Cambridge VPD Heart & Lung Research Institute with an internship AstraZeneca across the road? Then this MRC iCASE studentship is for you (due: March 4): jobs.cam.ac.uk/job/45195/! DMs open for any questions!

An exceptional opportunity to work with both academia and industry experts

Interested in pursuing a PhD focused on leveraging large-scale multi-omics data for multi-comorbidity analysis of cardio-renal-metabolic diseases? Don't miss this exceptional opportunity (ddl: 4th March) - jobs.cam.ac.uk/job/45195/ BHF Cardiovascular Epidemiology Unit at Cambridge VPD Heart & Lung Research Institute AstraZeneca

New exciting GWAS of type 2 diabetes in Nature in ~2.5 million individuals (>0.4 million cases), ~40% of which are from non-European ancestries. The sample size is so big that now the authors can dissociate the genetic signals in different clusters and use the cluster-specific

The 2024 Lasker–DeBakey Clinical Medical Research Award recognizes Drs. Habener, Mojsov, and Knudsen, who developed GLP-1 medicines that have revolutionized the treatment of obesity. Learn more about this award-winning research: nej.md/3XOepUg

Very excited to announce this opportunity! A fully funded 4-year PhD studentship with the exceptional advantage to work with both industry and academia leaders in the field. A perfect blend of cutting-edge research and career development!