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Today is #TransDayOfVisibility Have a look at this blog post by our lab member @aeparena mildnerlab.utu.fi/2023/03/31/hap…

Nature discusses scientists' efforts to reduce their (unpaid & unappreciated) workload (nature.com/articles/d4158…). The thread by Andrew Akbashev summarizes this nicely. Not mentioned: many scientists also on temporary positions only #WissZeitVG

Thank you Suomen Akatemia | Research Council of Finland (and of course also the reviewers, who invest a significant amount of their time) for funding our research InFLAMES Flagship! We will do our best to prove that our proposal idea was correct.

12 years after nature.com/articles/47100…: nothing changed. Today starts the #AktionswocheWissenschaft on precarious employment situations in the German #Wissenschaftsbetrieb. All information here mittelbau.net/aktionswochewi… including the zoom link for todays 4pm CET kick-off meeting.

According to a new study in Science Magazine (science.org/doi/10.1126/sc…), more than 50% of both large natural lakes and reservoirs experienced volume loss over the last 30 years. In Finland, the water levels of almost 70% of the analyzed lakes are declining.

Do you think you have #macrophages and data interpretation all figured out? Read these 3 great reviews and think again... doi.org/10.1016/j.cell…, doi.org/10.1002/eji.20… & doi.org/10.1038/s41586…

Not only transcription factors regulate differentiation: David Lara-Astiaso and colleagues show in this CRISPR-screen masterpiece Nature Genetics that chromatin factors are crucially involved in normal and malignant hematopoiesis. nature.com/articles/s4158…

The view from our institute this week is just amazing! We enjoyed it a lot! Hope to see you all at the pride march this Saturday #Turku #turkupride2023 #Pride2023

Macrophage states: there's a method in the madness dlvr.it/SyX9hh #immunology

It seems that monocyte-derived microglia do exist under steady state conditions! And they can cause Dnmt3a-dependent motor pathology. Great study by Jung-Seok Kim from @TheJungLab. Congratulations! biorxiv.org/content/10.110…

Surprisingly, CCR2-deficient patients have normal numbers of classical monocytes, but show a reduced alveolar macrophage pool, indicating that monocyte might differentiate into AMs. Nice work by Jacinta Bustamante and Casanova Lab in Cell: sciencedirect.com/science/articl…

How to discover a new fungal commensal as an immunologist: Infect Il23a-/- mice with Candida, wonder they can’t be infected, analyze the fecal outgrowth et voila, get to name your own fungus: Kazachstania weizmannii is born! Such a nice story by @JungLab, hubs.la/Q02pPQRq0

A new player in #monocyte biology: C/EBPa controls Ly6Chi monocyte differentiation (are the remaining cells DC3?). Ly6Clow are present and may derive directly from MDPs. Congrats Sunny Kim from the Murphy lab. PNAS: pnas.org/doi/10.1073/pn…

Another great example that mouse hematopoiesis does not necessarily reflect the situation in humans: FLT3L regulates #monocyte (&DC and B cell) development in humans. Congrats Vivien Béziat & Co: dlvr.it/T6LHDc

New great paper by @TheJungLab, congrats! But we are confused: We found Cd209a+ #monocytes, GuermonprezLab Cd209a+ Flt3+ monocytes, @realFlorentGinhoux shows Cd209+ pro-DC3 and now @TheJungLab Cd209a+ MDP-derived monocytes. Is Flt3 the only difference or are they maybe all the same?

What? An Immunity paper without scRNA-Seq and new cell subset description? Thank you Marc Bajenoff & Co! CSF1 as an tethered endothelial-derived niche and growth factor for non-classical monocytes, the blood-resident macrophages: cell.com/immunity/fullt…

Live on stage in Turku: Burkhard Becher, Steffen Jung, and Ari Waisman: 07th of October; 12.30pm. Please register here: konsta.utu.fi/Default.aspx?t…. And don't worry, you don't have to pay €1500 like you do for Keystone - ours is for free!

The deuterium fate mapping saga goes into the 2nd round in Journal of Experimental Medicine: congrats to Simon Yona and all coworkers for the investigation of DC circulation time in humans: doi.org/10.1084/jem.20…. We are excited: For a trilogy we need a third one! What is next?

Together with Simon Yona  and Ki-Wook Kim Lab we wrote a new monocyte review - don't be afraid, not in the F journals, but in Discovery Immunology Journal (doi.org/10.1093/discim…). You have to check out Figure 2. Do you find the hidden messages?

7 MDP-derived and 3 GMP-derived cell subsets were described within the Ly6C+ CD115+ gate. Are all these distinct #monocyte populations or do we have doppelgängers within them? We discussed this with Simon Yona in Science Immunology. Check here: science.org/doi/10.1126/sc…