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Our paper on nucleosome repositioning in CLL is now published in Genome Research! Led by Kristan Piroeva in our lab, collab with Kostareli_Lab, Karsten Rippe genome.cshlp.org/content/33/10/… ▶️Aggressive cancers have shorter nucleosome spacing ▶️Distinguish cancer subtypes from nuc patterns

Last week I presented our lab’s work at the Cancer Tech Accelerator Conference at Roche. It was a great event and I met amazing people in science, technology and business. Thank you very much to my supervisor for this opportunity, the organisers and the attendees! ✨

Happy Lunar New Year! Let it bring peace, health, happiness and good luck. If things did not go well with the previous New Years this year, it's a possibility to reset. Let it be good!

Excited to present the first ageing clock based on nucleosomics of cell-free DNA (cfDNA)! onlinelibrary.wiley.com/doi/10.1111/ac… ✅ Nucleosome repeat length increases with age ✅ Can predict age with ~3 year precision Congrats to Mariya Shtumpf, nrnflowers, Mila Bikova, Hulkar_M, Lumi Ruje!

Congratulations to Isabella Ciuta for successful MSD viva! Bravo!

Our paper on nucleosome repositioning in breast cancer is now published in Clinical Epigenetics! …lepigeneticsjournal.biomedcentral.com/articles/10.11… ▶️Nucleosome gain marks deregulated TFs ▶️Shorter distances between nucleosomes in cancer ▶️NRL affected by gene expression, methylation, H1 histones, repeats

Our lab proudly presents graduates of this year! Mila (top BSc of this year across our school), Isabella (Employee's Choice Award, Chancellor's PhD Fellowship), Clark (aced MSD, got into the NHS) and Seihee (best capstone project in BSc Data Science, accepted for PhD in Imperial)

Happy to contribute to this new preprint by Elena Pugacheva, Victor V. Lobanenkov 🇺🇦 & Co. What determines differential CTCF binding, beyond DNA methylation and TF/nucleosome competition? Answer: a specific nucleosome downstream of CTCF motif. Directionality matters! biorxiv.org/content/10.110…