🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

I see so many new TPD agents reported that are supported by datasets which range massively in quality, so I’ve put together a simple guide for those in the field to help them identify the good agents from the rest using just 3 simple tests. See my blog. janusdrugdiscovery.com/240125-quick-g…

📣 We’re excited to announce our latest agreement with Astellas subsidiary, Nanna Therapeutics! Under the agreement, Nanna will access our DUB-focused #drugdiscovery platform to support the development of novel therapeutic candidates for multiple disease targets: rb.gy/dg71e4

#NewNProt: Measuring small molecule-induced degradation pathway in living cells with #luciferase and #HaloTag-based reporter assays bit.ly/3w5eYxI

Dr Tia Salter (she/her) and Will Allen's Bristol Biochemistry new paper: adaption of NanoLuc protein transport assay enables in vivo screening for inhibitors of bacterial secretion doi.org/10.1101/2024.0…… @bbsrc and Wellcome funded

Maybe this is an open secret in the industry. In this manuscript, we put this open secret on paper. 😀 Lysineless HiBiT and NanoLuc Tagging Systems as Alternative Tools Monitoring Targeted Protein Degradation #TPD biorxiv.org/content/10.110…

Delighted to share the last study of the lab led by the fantastic postdoc Luis Carlos Tábara Rodríguez out in Cell !!! We show how MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA levels. MRC MBU Cambridge University authors.elsevier.com/sd/article/S00…

Functional characterization of pathway inhibitors for the ubiquitin-proteasome system (UPS) as tool compounds for CRBN and ... biorxiv.org/cgi/content/sh… #biorxiv_biochem

We recently discovered a priority code in presequences of mitochondrial precursors. Some are much ‚stronger‘ than others because they specifically recruit Hsp90 cochaperones and make use of Tom70. Very unexpected, at least for us. You can read the preprint biorxiv.org/content/10.110…

Determining how many cells to average for statistical testing of #microscopy experiments. A Viewpoint from Adam Zweifach UConn MCB: hubs.la/Q02Dq50p0

Online Now: Hexokinase 1 forms rings that regulate mitochondrial fission during energy stress dlvr.it/T9K69n

Want to degrade SNAP-tagged proteins? Take a look at our SNAP-#PROTACs. Great collaboration with Mariell Pettersson and team, Francesca Bottanelli lab, ACE from ZMB CRC 1430 Congrats and a big thank you to everyone who contributed! biorxiv.org/content/10.110…

New print posted from the group Amgen 🧪🔬🧬. We describe VIPER-TACs that leverage viral E3 ligases for disease-specific targeted protein degradation. This concept dramatically expands he druggable space to include pan-essential proteins. 🧵 #mycompany biorxiv.org/content/10.110…

SNAP-tag2: faster and brighter protein labeling biorxiv.org/content/10.110…

We are releasing Chai-1 via a web interface for free, including for commercial applications such as drug discovery. We are also releasing the code for Chai-1 for non-commercial use as a software library. Web interface: lab.chaidiscovery.com Code: github.com/chaidiscovery/…

Published today in nature, we describe an approach for single-molecule protein reading on Oxford Nanopore arrays. By utilizing ClpX unfoldase to ratchet proteins through a CsgG nanopore, we achieved single-amino-acid sensitivity. nature.com/articles/s4158…

Check out @JamesLorriman 's paper on the mitochondrial import/cleavage of PINK1, including lots of surprises! Super collaboration with Collinson Lab Robin Corey @robincorey.bsky.social & adam grieve (Bristol Biochemistry University of Bristol School of PPN University of Bristol) Wellcome PhD funding (James) biorxiv.org/content/10.110…

Development of a p62 biodegrader for autophagy targeted degradation biorxiv.org/content/10.110…

A library of fluorogenic dyes enables the measurement of protein unfolding for a large range of proteins go.nature.com/4ajNRNp rdcu.be/d8LZH

Proteins are still pretty hard to measure. Traditional approaches (e.g., phage, yeast, ribosome display) rely on DNA barcodes + NGS, but face throughput constraints + quirks. Infinity Bio has created a "self-assembling" DNA-barcoded libraries. The goal: screen drugs against

This isn't science fiction. This is real sequencing biotechnology just introduced by Roche. Wild and wonderful.