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These results show that physiological mitochondrial turnover occurs robustly throughout natural aging in the mammalian CNS, challenging the assumption that widespread decreases in mitophagy & autophagy are a universal consequence of mammalian #aging embopress.org/doi/full/10.10…

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A Rapalog prestigiuous GIN

In mitochondria, respiratory supercomplexes (blue) pump protons across crista membranes to create an electrochemical gradient, fueling adenosine triphosphate (ATP) synthase (pink) to regenerate ATP—the energy currency of life. Now, cryo–electron tomography captures these

Good Sunday Mito-friends. Here a new selection of papers related to #MitochondrialMedicine presorted by Bims: Biomed News biomed.news/bims-mitmed/20… biomed.news/bims-mitmed/20… Mitochondrial damage in PolG mutant mice activates the ISR and disrupts the mitochondrial folate cycle

✨New issue! ✨ Check out the latest in #metabolism research from across all disciplines. Read about #Macrophages, #Tcells, #Circadian biology, the effects of #Diet on #Body and #Brain - and many more topics! nature.com/natmetab/volum…

nature.com/articles/d4158…

Good morning Mito-friends. Here a new selection of papers related to #MitochondrialMedicine presorted by Bims: Biomed News biomed.news/bims-mitmed/20… biomed.news/bims-mitmed/20… biomed.news/bims-mitmed/20… Metabolic rewiring by mito-dysfunction promotes mTORC1-dependent skeletal aging

New! Online now: NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging dlvr.it/TKT483

Good morning Mito-friends. Don't miss this new selection of papers related to #MitochondrialMedicine presorted by Bims: Biomed News biomed.news/bims-mitmed/20… Nicotinamide adenine dinucleotide (NAD) augmentation in neurodegenerative disease (NDD) is a multi-target approach.

AI tool can estimate biological age and improve predictions of survival outcomes for patients with cancer, suggests study in The Lancet Digital Health. 🔗 hubs.li/Q03lNq5L0

Good sunday Mito folks. Here a new selection of papers related to #MitochondrialMedicine presorted by Bims: Biomed News biomed.news/bims-mitmed/20… CAPTURE: The role of mitochondrial mRNA translation in cellular communication

Today I'm at NeuroFrance 2025 in Montpellier....who's here?

How can we design and deliver a successful in utero therapy? Inspiring talk from Tippi MacKenzie at #ASGCT2025 #IUGT Simon Waddington Mitochondrial Medicine

Beautiful and exciting presentation by Pierre Vanderhegen at NeuroFrance 2025 #mitochondria #neurodevelopment

Good sunday Mito folks. Don't miss this new selection of papers related to #MitochondrialMedicine presorted by Bims: Biomed News biomed.news/bims-mitmed/20… CAPTION: Prenatal diagnosis of a compound heterozygous variation in the FBXL4 gene by trio-WES and imaging monitoring

Organoids --> Assembloids --> Humanoids

Good morning Mito-community. Don't miss this new selection of papers related to #MitochondrialMedicine presorted by Bims: Biomed News biomed.news/bims-mitmed/20… Modelling POLG mutations in mice unravels a critical role of POLγΒ in regulating phenotypic severity

Good morning Mito-community. Don't miss this new selection of papers related to #MitochondrialMedicine presorted by Bims: Biomed News biomed.news/bims-mitmed/20… Capture: Mitochondrial clonal mosaicism encodes a biphasic molecular clock of aging

Good morning Mito-friends. Don't miss this new selection of papers related to #MitochondrialMedicine presorted by Bims: Biomed News biomed.news/bims-mitmed/20… Impaired Complex I dysregulates NPCs and corpus callosum development revealing postnatal defects in Leigh Syndrome mice