🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Congratulations to Dr. Akanksha Jain (Akanksha Jain), Gilles Gut, and the Treutlein lab and Gray Camp on their work live imaging brain #organoid growth! nature article: go.nature.com/4la2yZh Episode with discussion: bit.ly/4nzLrCp

Intro to 2 new studies from my lab on somatic mutations in liver disease. 1st is about a mutated gene that leads to improved clone fitness and organismal health (CIDEB). The 2nd is about a mutated gene that leads to improved clone fitness but worse overall health (TBX3). 1/8

Metabolic adaptations direct cell fate during tissue regeneration | Nature nature.com/articles/s4158…

Atlas of amnion development during the first trimester of human pregnancy Nature Cell Biology Magdalena Zernicka-Goetz nature.com/articles/s4155…

The VGZT 🌟Season 6 Finale for *Western* Session🌟is on July 17th! Our speakers are: 👉 Josh Brickman 🐁🧍🏻‍♂️ 👉Charlène Ryan-Guillot 🐔🐦 “Control of epiblast fate by mechanical cues” Sadly, we come to an end and thank you everyone for this fantastic season!

Our PostDoc Debojit Saha recently attended a CSHL Courses & came back with new techniques and stunning images. This mouse E9.5 embryo, labeled with Raldh2 (red), Fgf8 (green), Msx1 (magenta), DAPI (blue) is just one example. #Fluorescence revealing the magic of development!✨

Juxtaposition of human pluripotent stem cells with amnion-like cells is sufficient to trigger primitive streak formation biorxiv.org/content/10.110…

Hu, W., Sancho-Serra, C., Gantner, C.W. et al. Atlas of amnion development during the first trimester of human pregnancy. Nat Cell Biol (2025). doi.org/10.1038/s41556…

Introducing digital embryos! Researchers at Southeast University Nanjing reconstruct full digital embryos at single-cell resolution during early #organogenesis. 📑 Cell: bit.ly/44EzzX0 🎧: bit.ly/4nzLrCp

🔥NEW paper from our lab! Ever wondered how the metabolite/lipid composition of human bone marrow HSCs changes during differentiation,aging,AML? Check our work nature.com/articles/s4155… driven by the brilliant Mari Carmen Romero-Mulero & Marialena Lalioti with Jörg! MPI of Immunobiology & Epigenetics ETH Zurich Nature Cell Biology

BRD4 acts as a pH sensor to tune inflammation bit.ly/3IOIyNU

Using newly developed mouse models and a microglia replacement strategy, researchers in Science show that bone marrow transplantation could be used as an effective therapy for ALSP, a rare and fatal neurodegenerative disease. 📄: scim.ag/4kW4jsR #SciencePerspective:

We traveled to DC to talk to Congressional Staffers about the impact of NIH NIBIB funding. It enables us to develop synthetic biology tools to advance cell & genetic medicines for patients in need. REPOST to deliver the message that SCIENCE saves lives & makes America great!

Our paper is out! We show how the extracellular matrix guides body axis formation in mouse—and possibly human—embryos during early pregnancy. Grateful to Magdalena Zernicka-Goetz Zernicka-Goetz Lab for the chance to work with mouse, human, and stem cell–derived embryo models. nature.com/articles/s4146…

Diet/microbes place the gut epithelium as a nexus for evolutionary change. With Jason Spence Craig Lowe, we use #organoids to explore how evolution prepared the developing human intestine for exposure to the environment. Science Magazine #evodevo 🧵1/11 science.org/doi/10.1126/sc…

This week: the #metabolomics of HSPCs! A new Nature Cell Biology study from Marialena Lalioti, Mari Carmen Romero-Mulero, Joerg Buescher, and Nina Cabezas-Wallscheid identifies metabolic changes that occur with differentiation, aging, and #AML. 📝- go.nature.com/4kOZVLX 🎧- bit.ly/44YrzjU

The intersection of AI and biofabrication is a thrilling frontier. We're witnessing AI's role in 3D printing living tissues, a development that could redefine regenerative medicine. In recent breakthroughs, AI has been used to optimize printing parameters, ensuring that tissues

🐌💫 Snail embryos never looked so fabulous! Tubulin (white), phospho-histone H3 (pink), and F-Actin (cyan) light up this early stage like a cytoskeletal disco ball. Image from Clemens Cabernard & Adam von Barnau Sythoff 🪩🧬 #FluorescenceFriday

* proteomic blueprint of #human #organs across 50-year #aging stages *Transcriptome-proteome decoupling and proteostasis failure mark aged tissues *Human organ proteomic clocks reveal aging inflection and asynchrony *Circulating senoprt >> to vasc aging cell.com/cell/abstract/…

Had a great time discussing our new studies on how embryo builds itself & how it can be used for #regenerative #medicine with my friend and colleague Susana Chuva de Sousa Lopes visiting #Pittsburgh Magee-Womens Research Institute & Foundation #embryomodel #Development Joshua Hislop