Molecular Metabolism
@molmetab
Molecular Metabolism is an open access journal reporting breakthroughs with the potential for transformative impact on today's metabolism research.
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http://molecularmetabolism.com 16-10-2014 06:21:20
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How do #GLP1 conjugates release their therapeutic cargo? This study shows that endolysosomal acidification enables release and #metabolism of #estradiol (E2). 👩🔬👨🔬Aaron Novikoff Helmholtz Diabetes Center (HDC) 🔗sciencedirect.com/science/articl…
Happy to share our latest paper showing that deletion of adipose-derived Isthmin-1 leads to fatty liver and elevated ceramides. Congrats to first author Saranya Reghupaty and all the co-authors! Molecular Metabolism Stanford Pathology Stanford Diabetes Research sciencedirect.com/science/articl…
#Registration for the 12th Helmholtz Diabetes Conference 𝙤𝙥𝙚𝙣𝙨 𝙨𝙤𝙤𝙣! 📍 Munich, 22–24 September 2025 📌 Speakers list: t1p.de/9x8hc 🏆 Lecture Award: Philipp Scherer UT Southwestern Medical Center Learn more: t1p.de/zegxf #StayTuned #HelmholtzDiabetes2025
Excessive #exercise activates PARP1 and triggers global protein #PARylation in muscle, impairing mitochondria and performance. This study reveals a stress-linked mechanism driving exercise-induced #muscledysfunction. 👩🔬👨🔬Unicamp Global Barbara Crisol 🔗sciencedirect.com/science/articl…
Gut microbiota-derived extracellular vesicles exhibit diurnal regulation and activates hepatic gluconeogenesis Molecular Metabolism sciencedirect.com/science/articl…
Studies in mouse #islets reveals the resistance of α-cells to the impacts of RNA editing deficiency and to cytokines mirrors their persistence in #T1D and constitutes a molecularly defined model of differential islet cell vulnerability. sciencedirect.com/science/articl… Molecular Metabolism
#BetaCell-specific deletion of #C3aR1 impairs #insulin secretion, reduces β cell mass, and increases susceptibility to lipotoxicity. This study highlights C3aR1 on β cells as a potential therapeutic target in #T2D. 👩🔬👨🔬Weill Cornell Medicine Weill Department of Medicine 🔗sciencedirect.com/science/articl…
Sex Hormone-Binding Globulin Controls Sex-Specific Lipolytic Activity in Human Abdominal Subcutaneous Adipocytes Molecular Metabolism sciencedirect.com/science/articl…
A once‑daily GLP‑1/GIP/glucagon receptor #triagonist, NN1706, causes significant dose‑dependent #weightloss in obese rodents, non‑human primates, and humans while maintaining glycemic control. 👩🔬🧑🔬Novo Nordisk US Indiana University 🔗sciencedirect.com/science/articl…
Excited to share our new publication in Molecular Metabolism on sex-specific actions on human adipose tissue through Sex Hormone Binding Globulin (SHBG)! Our study provides new insights into how SHBG regulates lipolytic pathways through adipocyte internalization. sciencedirect.com/science/articl…
Excited to share that our new study has been just published in Molecular Metabolism . In this work, we uncover an unexpected role for kidney #GLUT2 in regulating whole-body energy metabolism under non-diabetic conditions. By selectively deleting GLUT2 in kidney proximal tubule cells, we
New paper from Jakub Bunk and Mina Ersin in our lab: CKB is the key creatine kinase driving UCP1-independent #thermogenesis in beige fat via the futile creatine cycle (FCC). doi.org/10.1016/j.molm… Rosalind & Morris Goodman Cancer Institute McGill Biochemistry Molecular Metabolism
Revisiting NPY2R #obesity Studies in mice reveal synergistic activity of NPY2R and GCGR/GLP-1R agonism via survodutide is an attractive anti-obesity target #weightloss sciencedirect.com/science/articl… Molecular Metabolism
