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What human experimental models do we currently have to study brain disorders—and where do they fall short? In our recent Annual Reviews of Neuroscience, Rebecca J. Levy and I examine the current landscape of human stem cell models—2D systems, 3D #organoids, #assembloids, and

DKFZ at #AACR25 in #Chicago Vielen Dank an die Organisatoren und alle, die dabei waren! 👏 Wir freuen uns schon auf nächstes Jahr! 🤗 Many thanks to the organizers and everyone who attended! 👏 We are already looking forward to next year! 🤗 AACR NCT Heidelberg VomLaborInDiePraxis

This week we welcome the 2025 class of students for our hands-on Stanford Stanford Brain Organogenesis Center course. With students joining from across the globe, this is our most international class yet—diving into cutting-edge neural #organoid and #assembloid methods, ready to bring them back to

Integrated Organoid Atlas benchmarks new protocols, even more impressive as a Highly Variable Cohort for comparison against perturbation and disease models: nature.com/articles/s4158… Lead by Quan Xu 许泉 Lennard Halle, MD Collaboration with Fabian Theis Treutlein lab Institute of Human Biology

🧠 Excited to share my main PhD project! We mapped the regulatory rules governing Glioblastoma plasticity using single-cell multi-omics and deep learning. This work is part of a two-paper series with Omer Ali Bayraktar , Oliver Stegle and Moritz Mall groups. Preprint at end🧵👇

How does tumour heterogeneity arise? How can we predict cancer cell plasticity? In 2 studies, we trace #glioblastoma heterogeneity to a spatial cancer cell trajectory w. atlassing bit.ly/4mkrWgs & predict plasticity w. snRNA/ATAC+deep learning bit.ly/3FbI6Ic 🧵

There are many implications & LOTS of detail in the preprints (e.g. mesenchymal cancer states is really a gliosis/hypoxia response & GB tumour subtypes are likely confounded) bit.ly/4mkrWgs bit.ly/3FbI6Ic

Vielen Dank für die große Ehrung und die starke Unterstützung durch das DKFZ, das Hector Institut & alle Partner! Gemeinsam treiben wir in Heidelberg die Krebsforschung voran – die spannendsten Entdeckungen kommen erst noch. 🙏📷🔬#HellaBühlerPreis #TeamScience

Today is #EndangeredSpeciesDay! Dr. Sebastian Diecke's team is using iPSCs and #organoids to study and potentially rescue the highly endangered Sumatran rhinoceros. 🦏 Learn more in this episode from 2024: bit.ly/3FkQyox

Maarten van den Hoogenhof found a specific way to improve cardiac function in RBM20 cardiomyopathy. CAMK2 inhibition might become the first tailored therapy for a Dilated Cardiomyopathy (after mavacamten for Hypertrophic Cardiomyopathy): biorxiv.org/content/10.110…

The Single-cell Analytics Innovation Lab Memorial Sloan Kettering Cancer Center is looking for ML-oriented computational biologists. Join our team based in NYC to work on cutting-edge single-cell & spatial transcriptomics methods in collaboration with leading research labs. bit.ly/4lTEr2t

Der Deutsche Preis für #Krebspräventionsforschung, gestiftet von der Manfred Lautenschläger-Stiftung, geht in diesem Jahr an Ute Mons vom DKFZ und Carolin Schneider von der Uniklinik RWTH AC. Herzlichen Glückwunsch! 👏 ➡️t1p.de/10zwp

Sehr verdiente Preisträger - herzlichen Glückwunsch! Tolle und ausgesprochen wichtige Forschung um die Krebsprävention weiter voranzubringen!

Brain Prize winner Michelle Monje🎗️ 🟦 , Professor of Pediatric Neuro-Oncology at Stanford University, is giving her Brain Prize Lecture “The Neuroscience of Brain Cancer” at the University of Copenhagen. She is a leading voice in bridging neuroscience and oncology. #BrainCancer

Andreas Meyer-Lindenberg, Chair of the Selection Committee, on awarding the 2025 Brain Prize: “For their groundbreaking contributions to our understanding of how neural mechanisms influence brain tumour biology—an entirely new field at the interface of neuroscience and oncology.”

Brain Prize winner Frank Winkler, Prof. of Neuro-Oncology at Heidelberg University, is delivering his Brain Prize Lecture: “Neural influences on adult brain tumors: from bench to bedside” His groundbreaking research reveals how neurons drive brain tumour progression. #BrainPrize

König Frederik X. von Dänemark überreichte gestern dem Neurologen Frank Winkler (DKFZ, Uni Heidelberg & Universitätsklinikum Heidelberg) den #brainprize 🏅für bahnbrechende Arbeiten zu Interaktionen des Nervensystems mit Krebstumoren.👏Winkler teilt sich den Preis mit Michelle Monje (Stanford University).