🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Did you know that bacteria remember their past for many generations? In this new preprint from us (Alexis Villani and Senen Mendoza) and Banin lab (Esther Shmidov ), we reveal the "how?" and "why?" underlying a long-standing mystery in bacterial memory. biorxiv.org/content/10.110…

First month as #newPI is in the books. Check out my lab website to learn more about the lab and opportunities. We have openings at all levels. If you are interested in cryoEM/cryoET to work on stress signaling pathways, please reach out. sites.northwestern.edu/sangwan/

.NIAID News has announced a $6M funding opportunity to establish Centers for Accelerating #PhageTherapy to combat ESKAPE pathogens. By this time next year, 2-3 phage therapy centers in the US will be funded. Deadline: Jan 28, 2025 Reach out to: Kyung Moon buff.ly/3C37jme

Something for #phage phans 👇 #StructuralBiology

Here is a video that summaries the key findings! Once again, special thanks to my wonderful mentor Jun Liu Lab at Yale School of Medicine YaleMicroPath. Lots more discoveries to come at McGill Medicine and Health Sciences Anatomy&CellBiology CRBS McGill !

Phage CRISPR-like regulatory RNAs silence bacterial adaptive and innate immunity biorxiv.org/cgi/content/sh… #biorxiv_micrbio

🧵Epigenetics require the coordinated interplay of diverse proteins and mechanisms. To systematically explore this, we invented the COMBINE platform to quantify the effect of >50,000 pairs🧦of long epigenetic effectors on endogenous human transcription biorxiv.org/content/10.110…

🙋🏻🔬 Will you be joining us for #EMBOinsitu? What are the recent methodological developments and new tools for cell biology across scales: from molecules to organelles, cells and cell-cell interactions❓ How does one meaningfully integrate data from different methods❓ What

APEX peroxidase is a versatile tool for proximity labeling and electron microscopy (EM) but its requirement for toxic H2O2 is a liability. We now report LaccID, a multicopper oxidase evolved from an ancestral fungal laccase that oxidizes aromatic substrates using non-toxic O2

Keystone Meeting: Imaging Biomolecules Across Scales; March 23-26, 2025. Registration now open: keysym.us/KSImaging25

I am very proud to share our paper on Tad1/Tad2 sponges, which appeared to be multifunctional anti-defense proteins that inhibit many different signaling-based immunity systems!💫 nature.com/articles/s4158…

Hello Biophysical Society Cryo-EM Subgroup Members, As we approach the 2025 Biophysical Society Annual Meeting in Los Angeles, we need nominations for 5 Cryo-EM Subgroup leadership positions. This is a great chance to become more involved with the Society and to support the Cryo-EM

Cyclic nucleotide signals are a common anti-phage mechanism. How can (jumbo) phage keep up? Sponges! See thread from Iana Fedorova, a very talented post-doc in lab. We (w/ Feng lab) report amazing diversity in ligands bound by phage proteins Tad1/Tad2. 1/n rdcu.be/dYAVS

Eukaryotes have linear DNA and their telomeres are hotspots for transposons. Many bacteria are also known to have linear genomes. We identified several families of independently evolved telomeric transposons. 1/7 biorxiv.org/content/10.110…

Are there virulent phages hiding in your bacterial culture? Here we find hundreds of virulent phage genomes in bacterial genome assemblies. Bioinformatic and experimental evidence indicate these are not contaminations, but represent persistent infections. biorxiv.org/content/10.110…

Sustained in situ protein production and release in the mammalian gut by an engineered bacteriophage. nature.com/articles/s4158…

RNA-guided systems span kingdoms, from bacterial immunity to eukaryotic gene regulation. How did they evolve? We traced the origins of CRISPR-Cas13 and identified its likely ancestor: an RNA-based toxin-antitoxin (TA) system. Here’s what we uncovered: cell.com/cell/fulltext/… 1/8

My lab’s first preprint! We used functional metagenomics to identify phage defenses in human and soil microbiomes. We scaled these selections while maintaining accuracy, enabling us to examine 9 habitats for defense elements against 7 phages. biorxiv.org/content/10.110… 1/10

Check out our new paper describing rAcrVIA1: an RNA anti-CRISPR that mimics guide RNAs to inhibit Cas13. Very fun project with stellar UW undergrad Victoria Hayes and collaboration with Ning Jia's group! science.org/doi/10.1126/sc…

You want to start tomography? Solve structures inside cells? Reach Nyquist😳? We have a website for you! tomoguide.github.io You'll find a tutorial on how to reconstruct tomograms, pick particles and do subtomo averaging, using different software! Hope it will be useful !