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I am excited to share our most recent work from the @baurlab published @nature revealing SLC25A51 expression regulates mitochondrial NAD+ levels and encodes the mammalian mitochondrial NAD+ transporter. #NAD #mitochondria #metabolism nature.com/articles/s4158…

(3/3) Measurements of free mitochondrial NAD+ in live cells; demonstration with recombinant system of direct transport activity in vitro; kinetic rate calculations; beautiful 3D reconstructions Jared Eller Jessie Lu Paul Oliphint

Kudos to my colleague Lulu Cambronne & collaborators (ClubCambronne, Baur Lab, & more) for a beautiful paper nailing down the long-missing human mitochondrial NAD+ transporter. A tour de force, using humanized yeast to boot! rdcu.be/b6YBL

cns.utexas.edu/news/researche…

Way to go ClubCambronne and collaborators! #TexasScience #WhatStartsHereChangestheWorld 🤘🎉 cns.utexas.edu/news/researche…

SLC25A51 is identified as the mitochondrial NAD+ transporter in mammallian cells. Independent confirmation from @Baurlab & Lulu Cambronne in @nature and David M. Sabatini & @nora_kory in Science Advances #NatMetabPicks nature.com/articles/s4158… advances.sciencemag.org/content/early/…

New resource online now! This quantitative #proteome map of the #human body demonstrates how understanding #protein levels can provide insights into #regulation, #metabolism, and human #diseases bit.ly/2ReMmu8

A study in Nature finds that the SLC25A51 gene dictates the transport of NAD+ to the mitochondria, where energy from nutrients is converted into chemical energy for the cell. go.nature.com/2GOiN0o

(1/8) In honor of our recent publication, we would like to make a thread commemorating UT’s immense history of metabolic biology!

BREAKING NEWS: The 2020 #NobelPrize in Chemistry has been awarded to Emmanuelle Charpentier and Jennifer A. Doudna “for the development of a method for genome editing.”

Emmanuelle Charpentier and Jennifer Doudna are the winners of the 2020 Nobel Prize in Chemistry for their work developing the revolutionary gene-editing technology CRISPR. go.nature.com/3iymapm

Our review is now online at @natmetabolism! Here we address mechanisms that regulate nuclear metabolism and how cells manage metabolites between nuclear/non-nuclear compartments, with focus on regulation of epigenome. Thanks Ruben Boon and @giorgiasilveira rdcu.be/b8ppO

Our novel mitochondrial import method paper is out now at Molecular Cell🎉 It was a great pleasure to work with such great people, I hope this will enable #mitochondial #community to pave the way😍 Christian Münch Jasmin Schäfer JonasMichaelis Kevin Klann cell.com/molecular-cell…

Pretty wild: cancer cells more likely to spread during sleep (!) nature.com/articles/s4158… Interesting and dramatic example of how physiology intersects with fundamental cell biology-- here, circadian hormone rhythms and intravasation

New! Online now: SLC25A51 decouples the mitochondrial NAD+/NADH ratio to control proliferation of AML cells dlvr.it/T2lKXj

Researchers from NaturalSciences @ UT and #DellMed have discovered how an aggressive and deadly form of leukemia fuels its growth, and, in an experimental study, they were able to curb the growth of the cancer without harming healthy cells. bit.ly/3UEQeGs

Researchers have discovered a potential breakthrough in cancer treatment. Led by Xiaolu Cambronne of Molecular Biosciences, alongside Dell Medical School and UT Austin Nutrition, their study offers promising insights into treating aggressive cancers. Dive into the details: cns.utexas.edu/news/research/…

cns.utexas.edu/news/research/… Way to go Jessie Lu! A triple threat NaturalSciences @ UT collab ClubCambronne Tiziani Lab @BillMatsuiLab Molecular Biosciences セルメタ

authors.elsevier.com/a/1ibPS5WXUlWj… High-Impact/High Risk CPRIT Pew Health NIH gave our team led by first-author Jessie Lu the initial boost that has opened up so many opportunities in discovery and hopefully also future medicine👆NaturalSciences @ UT.

Thrilled to share my first "First Author" paper in the Ilya Finkelstein lab! Our recent publication in Nature Communications offers a comprehensive insight into Cas13d's RNA binding and cleavage specificity. nature.com/articles/s4146…