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Last week Alerie Guzman de la Fuente visited Asociación Granadina de Esclerosis Múltiple to discuss with MS patients and families the latest advances in #myelin research and potential remyelination therapies. Discussing our research with patients is always inspiring and a strong motivation to keep research going

New work from Yasmine Kamen shows that differentiating oligodendrocytes are filled with the zymogen procaspase-3. This provides a specific marker for new oligodendrocytes and suggests a role for this pathway in oligodendrocyte fate decisions. biorxiv.org/content/10.110…

A 2023 Review in Science Translational Medicine looks at the complex connections between astrocytes and other types of cells in the nervous system, including neurons, oligodendrocytes, and microglia. Learn more: bit.ly/4esssnw #ScienceMagArchives

Temporally distinct 3D multi-omic dynamics in the developing human brain | Nature nature.com/articles/s4158…

Today our PhD student, Sonia , presented a summary the publication that stemmed from her Master’s thesis at the IX Researchers Meeting at ISABIAL . Fantastic opportunity to share her findings with the medical community in Alicante.

#JNeurosci | Federico Miozzo 🇪🇺🇺🇦 et al. used mice to investigate how a gene associated with autism spectrum disorder and depression, Protocadherin 9, plays a role synaptic dysfunction and brain pathology. This study provides important molecular and synaptic insight. Instituto de Neurociencias UMH-CSIC

New work that builds on the growing evidence for microglia contributing to the seeding of amyloid plaques in a different model of AD. Curious as to whether differences exist between parenchymal and vascular amyloid seeding. nature.com/articles/s4146…

Immune mechanisms and shared immune targets in neurodegenerative diseases nature.com/articles/s4158…

Spatial transcriptomic clocks reveal cell proximity effects in brain ageing nature nature.com/articles/s4158…

🔵ISABIAL visibiliza en una jornada más de una decena de proyectos de investigación que han incorporado la perspectiva de género 👤La jornada ha sido inaugurada por la directora general de Investigación e Innovación, Mariola Penadés Más info: acortar.link/nO4lNY

📰 "Investigadores del Instituto de Neurociencias de Alicante descubren una nueva estrategia para combatir las metástasis cerebrales de melanoma". 🔬 Berta LSL Javier Rodriguez Jose P López-Atalaya GMB-lab 🏛️ Instituto de Neurociencias UMH-CSIC in.umh-csic.es/es/articulos/m…

Reversible reduction in brain myelin content upon marathon running | Nature Metabolism Does this open the door to novel myelin functions? Interesting study by ⁦Neurobiology Lab⁩ suggesting novel and exciting role for myelin to be further explored nature.com/articles/s4225…

A comparative transcriptomic analysis of mouse demyelination models and Multiple Sclerosis lesions biorxiv.org/content/10.110…

New online! Multiple sclerosis: an immune attack on astrocyte-mediated ion and water homeostasis bit.ly/4cjuh6x

Oligodendrocyte precursor cells facilitate neuronal lysosome release nature.com/articles/s4146…

Fonta, Page, Merkler et al. show that #oligodendrocyte-derived IL-33 regulates self-reactive CD8+ T cells in CNS #autoimmunity. IL-33 ablation reduces persistence and TCF-1low effector T cell generation, mitigating disease. hubs.la/Q03hcWPk0 #Neuroinflammation

Scientists have shown that activating neurons that promote hunger or satiety can mimic the immunoregulatory effects of fasting or feeding in mice, respectively. Learn more in Science Immunology: scim.ag/3E8tmt6

Today is #WorldMSDay. MS is a devastating immune-mediated neurodegenerative disease targeting myelin a lipid protective layer surrounding nerve fibres. Myelin loss leads to cognitive and motor symptoms that worsen over time. Currently we have no therapies to boost myelin repair

In #WorldMSDay we share with you the main topic of research in MS with our hub. Understanding myelin and immune system interaction to enhance myelin repair . Efforts to investigate mechanisms of myelin repair will hopefully yield new therapies to stop MS progression

Fantastic mentors are inspiring in many aspects and sometimes they have incredible stories behind, but passion is a common drive. Very glad to have her as one of my key mentors Fitzgerald Research Group qub.ac.uk/alumni/lanyon-…