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A strategy to enhance gene therapy may improve outcomes for patients with progressive vision loss from inherited retinal degenerations. #NIHfunded Penn Medicine News Molecular Therapy paper: brnw.ch/21wTmoS

Botulinum toxin type A improved neuropathic/nociplastic ocular pain and quality of life in a small study. Few noted improvement in light and wind/air sensitivity. Bascom Palmer Eye Institute #NIHfunded Elsevier | ScienceDirect paper: brnw.ch/21wTnoM

Congratulations to Steven J Fliesler, PhD, for receiving the 2025 Stockton Kimball Award in recognition of outstanding scientific achievement and service. #NIHfunded #retina Jacobs School at University at Buffalo Details: brnw.ch/21wTrp8

Long-approved HIV drug, lamivudine, shows promise in a clinical trial for treating diabetic macular edema. UVA School of Medicine #NIHfunded Med by Cell Press paper: brnw.ch/21wTt6Y

BLINK Study Group: Subfoveal choroidal thickness and area increased 2 weeks into wearing multifocal contact lenses to slow myopia and axial length growth. University of Houston Ohio State University Ophthalmology Duke Biomedical Engineering Ohio State Optometry IOVS Journal paper: brnw.ch/21wSZUQ

Decades of #NIHfunded work in the making: FDA approved ENCELTO, a first-of-its-kind eye implant that slows vision loss from macular telangiectasia type 2. The Lowy Institute Neurotech Pharmaceuticals Moorfields Eye Hospital NHS Foundation Trust News from Scripps Research: brnw.ch/21wTyvr

Can you eat away your risk for blindness? Tiarnán Keenan from NEI used data from AREDS1/2 (NIH trials) to explore the role of diet in patients already taking supplements. Details: brnw.ch/21wTBQ7

An epigenetic (DNA methylation-based) aging clock predicts mortality and intrinsic capacity (functional) decline (including in vision) better than earlier epigenetic clocks. #NIHfunded Buck Institute Nature Aging paper: brnw.ch/21wTDQw

#NIH released a #FundingOpportunity for the NIH Director’s Pioneer Award to support researchers pursuing bold and innovative approaches to major challenges. Learn more about this exciting initiative: bit.ly/3FYVRKI

#ICYMI: Special issue of IOVS Journal on myopia follows on National Academies report to look at animal models, visual diet, genetic & environmental risk factors, and treatment approaches. IOVS issue: brnw.ch/21wTFDT NASEM report: brnw.ch/21wTFDU

A reproducible framework: OCT-A image quality and analyses with variables from population-based studies of microvascular dysfunction in Alzheimer's disease and related dementias. #NIHfunded Johns Hopkins Medicine Alzheimer's Association paper: brnw.ch/21wTHCD

Insights into brain circuits downstream of the retina that are crucial for restoring vision in patients with retinal degeneration NIH Intramural NEI Krystel Huxlin SfN Journals paper: brnw.ch/21wTJmW

Heparan sulfate in Bruch's membrane may play a role in AMD by trapping lipoproteins and starting drusen formation. Targeting this interaction may prevent early AMD before vision loss occurs. Shiley Eye Institute UC San Diego School of Medicine #NIHfunded @PNASnews brnw.ch/21wTJxJ

Targeted gene editing therapy for glaucoma tested in mice. Knock down of two genes associated with aqueous humor production using CRISPR-Cas13 RNA editing systems lower IOP. #NIHfunded Stanford Medicine PNAS Nexus paper: brnw.ch/21wTMBk

A handheld, standalone device using shape discrimination hyperacuity has been developed to remotely monitor age-related macular degeneration. #NIHfunded U-M Kellogg Eye Center Johns Hopkins Medicine Stanford Medicine MDPI paper: brnw.ch/21wTOrE

A novel device (i-Onion) evaluates tear secretory response. Study shows tear reserve volume was preserved in glaucoma and cataract, despite decreased basal tear volume with age and disease Bascom Palmer Eye Institute The ECLA Journal: brnw.ch/21wTQcx

From 5000+ participants in the NIH AllofUsResearch: U-shaped relationship between HDL and AMD risk, such that both high and low HDL are significantly associated with increased AMD risk. Jimmy Chen Sally Baxter Jeff Esko AAO paper: brnw.ch/21wTSd7

Great piece on oculomics: Application of AI to deliver healthcare from the eye. Sally Baxter ROBERT N WEINREB Aaron Lee Shiley Eye Institute UC San Diego NEI JAMA Ophthalmology: brnw.ch/21wTUdG

Interesting review on approved AI-based ophthalmic imaging devices in the UK, US, and Australia. AI tools must be held to the same evidence standards as tests or drugs. Moorfields Eye Hospital NHS Foundation Trust Ariel Ong Eliot Dow Pearse Keane Alastair Denniston nature article: brnw.ch/21wTXzX

Based on 2500 people from the Health, Aging and Body Composition study: Visual impairment and poor mobility independently predicted mortality risk. #NIHfunded Wake Forest University Stephen Kritchevsky American Geriatrics Society paper: brnw.ch/21wTZbY