🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

“... there were no treatment-emergent adverse events that led to discontinuation of treatment with UBX1325 compared with sham. There were trends suggestive of potential efficacy; larger trials are needed to further evaluate these findings.” eviden.cc/4ifSZq4

2IQP trial: The benefits of automated insulin delivery are well established in type 1 diabetes, but its efficacy and safety in type 2 diabetes have been uncertain. Research findings in patients with type 2 diabetes are summarized in a new Quick Take video. youtu.be/a9cGPIPQ4Cc

Perspective by Rachel E. Sachs, JD, MPH, Joshua M. Sharfstein, MD (Joshua Sharfstein), and Patricia J. Zettler, JD (Patti Zettler): Judicial Invalidation of the FDA’s Laboratory-Developed Test Rule — Legal and Public Health Consequences nej.md/3RP3HsT #HealthPolicy

Original Article: Efruxifermin in Compensated Liver Cirrhosis Caused by MASH (SYMMETRY trial) nej.md/4kru98f EASLnews | #EASLCongress

𝐈𝐧𝐭𝐫𝐨𝐧𝐬 are noncoding nucleotide sequences within genes, which are spliced out during the production of mature, protein-coding messenger RNA (mRNA). Introns contain sequence elements that enhance gene expression and mediate alternative splicing of mRNA to produce different

Christopher P. Duggan, MD, MPH, discusses the effects of ending U.S. foreign-assistance and global health programs. Listen to the full interview with NEJM Executive Managing Editor Stephen Morrissey (Stephen Morrissey): nej.md/435tJxe

The aldosterone synthase inhibitor lorundrostat may be an effective treatment for uncontrolled, treatment-resistant hypertension. Research findings from the Advance-HTN trial are summarized in a new Quick Take video. nej.md/4iUsNRT

Original Article: BCG Revaccination for the Prevention of 𝘔𝘺𝘤𝘰𝘣𝘢𝘤𝘵𝘦𝘳𝘪𝘶𝘮 𝘵𝘶𝘣𝘦𝘳𝘤𝘶𝘭𝘰𝘴𝘪𝘴 Infection (BCG REVAX trial) nej.md/3GKdPkf Editorial: To BCG or Not Two BCG nej.md/433f710 #IDTwitter #GlobalHealth

Nutrition in Medicine article by Giulia Menichetti, PhD (Giulia Menichetti), Albert-László Barabási, PhD (Albert-László Barabási), and Joseph Loscalzo, MD, PhD: Chemical Complexity of Food and Implications for Therapeutics nej.md/3EEDtq4 #NutritionScience

A 6-month-old girl was brought to the emergency department with a 3-day history of redness and swelling of a toe. A physical examination is shown. What is the most likely underlying cause of the findings? Submit your answer or see how others responded: nej.md/IC05082025

𝘔𝘺𝘤𝘰𝘣𝘢𝘤𝘵𝘦𝘳𝘪𝘶𝘮 𝘵𝘶𝘣𝘦𝘳𝘤𝘶𝘭𝘰𝘴𝘪𝘴 continues to cause substantial illness globally. The efficacy of BCG revaccination for the prevention of sustained 𝘔. 𝘵𝘶𝘣𝘦𝘳𝘤𝘶𝘭𝘰𝘴𝘪𝘴 infection is unclear. Findings from the BCG REVAX trial are summarized in a new

Original Article: A Randomized Trial of Automated Insulin Delivery in Type 2 Diabetes (2IQP trial) nej.md/4ioCwR2 Editorial: Automated Insulin Pump in Type 2 Diabetes nej.md/3GFUBvY #Endocrinology

The dismantling of foreign-assistance efforts has already had, and will continue to have, severe effects on vulnerable populations globally, argue Christopher P. Duggan, MD, MPH, and Zulfiqar A. Bhutta, MB, BS, PhD, in a new Perspective. But it also has implications for people in

Presented at #ECO2025: In the SURMOUNT-5 phase 3b trial involving adults with obesity without type 2 diabetes, tirzepatide was superior to semaglutide in reducing body weight and waist circumference. Full trial results: nej.md/44ZeMPz EASLnews

Images in Clinical Medicine: Central Nervous System Tuberculomas nej.md/4k2iWKZ #Neurology

Tension-free vaginal tape has been the standard treatment for female stress urinary incontinence. Transurethral injection of polyacrylamide hydrogel is an alternative. Freitas and colleagues report on 5-year follow-up of a trial comparing the two. eviden.cc/4j7weWm

Original Article: Lorundrostat Efficacy and Safety in Patients with Uncontrolled Hypertension (Advance-HTN trial) nej.md/4ipbCIf #Endocrinology

Among patients with smoldering multiple myeloma at high risk for progression, progression-free survival at 5 years was 63.1% with daratumumab monotherapy, as compared with 40.8% with active monitoring. Full AQUILA trial results and Research Summary: nej.md/3Zh3pOJ

From the NEJM Archive: Benign and Malignant Tumors of the Small Intestine (Original Article, May 8, 1947) nej.md/4jLxzlZ

𝘔𝘺𝘤𝘰𝘣𝘢𝘤𝘵𝘦𝘳𝘪𝘶𝘮 𝘵𝘶𝘣𝘦𝘳𝘤𝘶𝘭𝘰𝘴𝘪𝘴 continues to cause substantial illness globally. In the BCG REVAX trial, BCG revaccination did not prevent sustained 𝘔. 𝘵𝘶𝘣𝘦𝘳𝘤𝘶𝘭𝘰𝘴𝘪𝘴 infection in IGRA-negative, HIV-negative adolescents. Full trial results and