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A new guideline from ASTCT provides clinical practice recommendations for transplant and cellular therapies in diffuse large b-cell lymphoma. Review the #openaccess guideline: ow.ly/4VtQ50P9TuY Elsevier Hematology #LBCL Mehdi Hamadani, MD Narendranath Epperla, MD, MS, FACP

Beyond youth: Understanding CAR T cell fitness in the context of immunological aging - NEW by Julia Han Noll 🧵sciencedirect.com/science/articl…

Genetic-subtype guided R-CHOP-X treatment resulted in superior DLBCL outcomes vs R-CHOP in the randomized phase 2 GUIDANCE-01 trial. Great effort exploiting subtype-specific vulnerabilities of DLBCL. Phase 3 trial vs R-CHOP is already ongoing. Cancer Cell cell.com/cancer-cell/fu…

#ASH23 Late breaking abstract 2 The long-awaited SYMPATICO trial Ibr+Ven vs Ibr+pbo RCT in R/R MCL - med PFS 31.9 vs 22.1 months, HR 0.65 p = 0.005 - median OS 44.9 vs 38.6 mo (not significant) ash.confex.com/ash/2023/webpr… h/t David Russler-Germain, MD/PhD #lymsm

Impact of circulating lymphoma cells at diagnosis on outcomes in patients with marginal zone lymphoma: a multicenter cohort study | Blood Advances | American Society of Hematology ashpublications.org/bloodadvances/…

#ScienceSaturday Can dietary nutrients help the immune system kill #cancer cells? In this study, researchers screened 255 circulating nutrients for the ability to enhance T cell activity and found that the long-chain fatty acid TVA (Trans-vaccenic acid) could enhance the

We are looking forward to working on this more- adding ⬆️ cases & analyses (45-49% vs <45% split was arbitrary but may be relevant). Much more work in this area is needed as these #lymphoma pts are often excluded from clinical trials. Narendranath Epperla, MD, MS, FACP Raul Cordoba, MD, PhD #ASH23 #CardioOnc

Multicenter CNS involvement in HGBL NOS Narendranath Epperla, MD, MS, FACP: - 160 pts, 7% baseline CNSi - CNSi➡️MYC-R, testicular/female pelvic - no diff in PFS/OS for CNSi vs not (2-yr PFS 53-55%) - 11% CNS relapse at 3 years - mOS 6-7 mos at relapse regardless of CNSi #lymsm ashpublications.org/bloodadvances/…

nejm.org/doi/full/10.10…

Exciting discovery: CSF flow isn't confined to the brain and spinal cord—it also extends to peripheral nerves! Science Magazine science.org/doi/10.1126/sc… Groundbreaking research from UF Health FLORIDA #neurotwitter #neuroscience #AcademicChatter

Cardiac considerations with Emerging Cancer Cellular Therapies: ashpublications.org/bloodadvances/… Thanks Blood Advances for publishing this work. Excellent work by Malak Munir Ahmed Sayed Narendranath Epperla, MD, MS, FACP #cardioonc #cancer #leukemia #lymphoma

The study shows the safety and long-term efficacy of auto-HCT, even in patients with high-risk cHL who are traditionally considered chemotherapy refractory. ow.ly/HTmq50U5zj6 #lymphoidneoplasia #transplantation

Happy to share this new study out in Blood Cancer Journal, coauthored by Narendranath Epperla, MD, MS, FACP. nature.com/articles/s4140…

In this statistical editorial, Larry Han, PhD, reviews the concept of left truncation in time-to-event studies. Read the editorial: eviden.cc/3ZiP0mb #ClinicalTrials

New 3i Investigator Article Alert!! Impact of circulating lymphoma cells at diagnosis on outcomes in patients with newly diagnosed de novo diffuse large B-cell lymphoma pubmed.ncbi.nlm.nih.gov/39757235/?utm_…

New online! Anthracycline-induced cardiomyopathy: risk prediction, prevention and treatment go.nature.com/40Pt42J

Second primary malignancies following CAR T-cell therapy in patients with hematologic malignancies #mmsm #bmtsm Marcos de Lima Narendranath Epperla, MD, MS, FACP jhoonline.biomedcentral.com/articles/10.11…

🚨 Just out Nature Medicine! Introducing InflaMix—a point-of-care tool that identifies an #inflammatory 🔥 signature predictive of #CART failure in #lymphoma Led by Sandeep Raj (Sandeep Raj) 👏Memorial Sloan Kettering Cancer Center nature.com/articles/s4159… 🧵Let’s break it down

1/ Why do late-stage cancer patients lose motivation & sink into apathy? 🔥Our new Science paper shows cancer activates a cytokine-sensing brain circuit to lower motivation.Great work by Aelita Zhu Sarah Starosta Marco Pignatelli Tobias Janowitz &team!🧵 🔗 doi.org/10.1126/scienc…