🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

😍This study investigated regulation of the splicing factor heterogeneous nuclear ribonucleoprotein-L (hnRNPL) in the failing heart. hnRNPL is altered in heart failure across species. Draper et al., FEBS Lett, 2024. NIH NHLBI (ORIP-K01OD028205) pubmed.ncbi.nlm.nih.gov/39300280/

🐷READ: “Impaired skeletal development by disruption of Presenilin-1 in pigs and generation of novel pig models for Alzheimer’s disease.” Uh et al., J. Alzheimers Dis., 2024. Mizzou CAFNR (ORIP support through U42OD011140) pmc.ncbi.nlm.nih.gov/articles/PMC11…

🧐READ: “Understanding early HIV-1 rebound dynamics following antiretroviral therapy interruption: The importance of effector cell expansion.” Phan et al., NIAID News, Los Alamos National Laboratory, Penn State Eberly College of Science (ORIP support through R01OD011095) pubmed.ncbi.nlm.nih.gov/38746144/

👀Researchers successfully reduced viremia in a highly pathogenic model of HIV in rhesus macaques, providing proof of concept for a new class of single-administration antiviral therapies. Pitchai et al., National Cancer Institute (ORIP- P51OD011092, U42OD010426) pubmed.ncbi.nlm.nih.gov/39116226/

✅READ: “A Comparative Review of Cytokines and Cytokine Targeting in Sepsis: From Humans to Horses.” Hobbs et al., Cells, 2024. NC State Vet Medicine (ORIP support through T32OD011130) pmc.ncbi.nlm.nih.gov/articles/PMC11…

Findings reveal short-term exposure to proinflammatory cytokines leads to diminished tight junction in canine intestinal organoids. Nakazawa et al., In Vitro Cell Dev Biol Anim., 2024. WSUVETMED (ORIP- K01OD030515, R21OD031903) 👉 Learn more: pmc.ncbi.nlm.nih.gov/articles/PMC11…

👉READ: “Impaired axon initial segment structure and function in a model of ARHGEF9 developmental and epileptic encephalopathy.” Wang et al., PNAS, 2024. NINDS Columbia Medicine (ORIP support through U54OD030187, U54OD020351, S10OD026974) pubmed.ncbi.nlm.nih.gov/39374387/

Mark your calendars🐵Session V of the #cryopreservation workshop will take place on Feb. 7 from 12:00 p.m.–5:00 p.m. EST. This workshop will discuss long-term preservation methods for nonhuman primate models in #BiomedicalResearch. 👉Register today: scgcorp.com/Cryopreservati…

🧑‍🔬Dive into this study describing the establishment and characterization of three new cell lines, derived from human ocular adnexal sebaceous carcinoma, to serve as models for #DrugDevelopment. Lee et al., Int J Mol Sci., 2024. (ORIP-K01OD034451) pmc.ncbi.nlm.nih.gov/articles/PMC11…

⚙️#ORIPResourceOfTheMonth. The National Xenopus Resource, National Xenopus Resource collaborates with The European Xenopus Resource Centre, supporting the Xenopus community by providing breeding, maintaining genetic stocks & distributing stocks to researchers. (ORIP- P40OD010997). Learn more: orip.nih.gov/division-compa…

Our new perspective article describing the human and non-human primate developmental GTEx projects is now out in nature! We outline the scope, vision, opportunities and challenges of these projects here: nature.com/articles/s4158…

🔍Scientists identify extended survival of 9- and 10- #Gene edited #Pig heart xenografts with ischemia minimization and CD154 costimulation blockade-based immunosuppression. Chaban et al., J Heart Lung Transplant, 2024. CAFNR News (ORIP- U42OD011140) pubmed.ncbi.nlm.nih.gov/39097214/

😍A placental #GeneTherapy approach to boosting the placenta is safe in monkeys, according to a new pilot study, which may bring treatment closer to improving birthweights of human babies. Wilson et al. (ORIP-P51OD11106, S10OD023526) pubmed.ncbi.nlm.nih.gov/39499161/

👨‍🔬In this #ResearchHighlight: The Center for Precision Medicine Models, at BCMHouston, is developing animal models that can be used to end the diagnostic odyssey for patients with #rarediseases. (ORIP- U54OD030165) Learn more about CPMM: orip.nih.gov/about-orip/res….