This study explores the mechanism behind green tea's ability to reduce the systemic exposure of raloxifene, a medication used for osteoporosis. The results indicate that green tea catechins decrease the drug's solubility in the intestines, particularly in the fasted state,

PBPK modeling predicts cannabinoid-drug interactions: In this study, the research utilized physiologically-based pharmacokinetic (PBPK) modeling to predict the extent of CBD-drug interactions. The model accurately predicted the magnitude of interaction for most CYP enzymes,

Kratom and Midazolam: A case study of drug interactions The study, published in Clinical Pharmacology & Therapeutics, assessed the impact of kratom on the pharmacokinetics of midazolam, a drug used for sedation and anxiety relief. Results showed a modest increase in midazolam

A comprehensive review highlights the potential for kratom to cause drug interactions by inhibiting key enzymes and transporters involved in drug metabolism. This can lead to increased drug levels and potentially dangerous consequences. Published in Drug Metabolism and

Kratom's complex chemistry: Uncovering Alkaloid variations This study analyzes the diverse alkaloid profile of kratom (Mitragyna speciosa) plants and products, revealing significant variations in their chemical composition. The study used ultra-high performance liquid

A limited sampling strategy for Fexofenadine: Can it accurately estimate P-gp and OATP1B1/3 activity? Fexofenadine is a common probe drug used to assess transporter-mediated drug-drug interactions (DDIs) involving P-glycoprotein (P-gp) and OATP1B1/3. This study evaluated a

Limited sampling strategies for Fexofenadine: A new study reveals challenges This study evaluated the accuracy of limited sampling strategies using fexofenadine to estimate P-glycoprotein (P-gp) and OATP1B1/3 transporter activities in healthy adults. The results showed that

A recent review underscores the need for clear and consistent criteria for assessing D-AKI in studies. This will enhance the effectiveness of pharmacovigilance efforts, ensuring greater transparency and reliability in identifying potential drug-related kidney damage. Published

This study examines the absorption, distribution, metabolism, and excretion of kratom alkaloids in humans. This research is crucial for understanding the potential risks and benefits of this popular botanical product. Published in Pharmaceutics by Tanna, Nguyen, Hadi, Manwill et

Grapefruit juice impacts Fexofenadine pharmacokinetics This study found that grapefruit juice significantly decreased the relative oral bioavailability of fexofenadine. This suggests that grapefruit juice may interact with P-gp and OATP1B1/3, the transporters fexofenadine is

Fexofenadine: Insights into limited sampling for transporter activity assessment This study examines limited sampling strategies for fexofenadine in healthy adults and highlights the importance of thorough validation. The research found that commonly used fexofenadine limited

Goldenseal & Metformin: What you need to know about this drug interaction This study in mice suggests that goldenseal, a common herbal supplement, may decrease metformin's effectiveness by inhibiting intestinal uptake transporters. While further research is needed, this finding

Importance of reporting herbal medicine use when taking Paxlovid™ - This study from NaPDI scientists emphasizes the importance of open communication between patients and healthcare providers about herbal medicine use when taking Paxlovid™. It highlights the lack of

New insights into green tea and drug interactions This study highlights the need for improved models to predict drug interactions involving UDP-glucuronosyltransferases (UGTs). The study investigating green tea and raloxifene found an unexpected decrease in raloxifene levels,

Green tea: More than just a healthy drink? While green tea is generally considered beneficial, this study reveals that it could potentially affect the absorption of some drugs. The study explored the interaction between green tea and raloxifene, finding a significant decrease in

PheKnowLator: Benchmarking and evaluating biomedical knowledge graphs A key challenge in KG research is the lack of comprehensive benchmarks for evaluating KG construction methods and their impact on downstream analyses. PheKnowLator provides a set of pre-built benchmark KGs in

Bridging the gap in natural product safety research: Improving data collection with AI-powered string matching Accurate data collection is crucial for understanding the safety of natural products. This study explored the effectiveness of a combined fuzzy string-matching and

The study reveals that the interaction between goldenseal and midazolam primarily occurs in the intestines, not the liver. This emphasizes the importance of considering potential drug interactions when taking supplements, especially for medications metabolized by intestinal CYP3A

While this study highlights a potential interaction between green tea and certain medications, further research is needed to understand the full implications for other drugs and individual patients. Published in Pharmaceutical Research (2024) by Oyanna, Bechtold, Lynch et al

Model predicts cannabidiol (CBD) levels in the body A physiologically-based pharmacokinetic (PBPK) model has been developed to predict how CBD is processed in the body. This model can be used to understand how CBD interacts with other medications and how it might be affected by