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Model shows how data on genetic, social, and lifestyle-psychological factors help better predict individual heart disease risk. bit.ly/3VvrIaq Mohammadreza Naderian Mayo Clinic CV Iftikhar J. Kullo Mayo Clinic

1/2 A UK Biobank analysis by Mohammadreza Naderian highlights the value of incorporating social & environmental factors as well as #PRS to improve CHD risk prediction Main findings: 1 SD increase in a polysocial score led to a HR of 1.43 & a 1 SD increase in PRS led to a HR of 1.59

Read about how including genetic, social, lifestyle, and psychological factors in clinical risk calculators for #heartdisease could improve their ability to predict coronary heart disease: bit.ly/4geejMh

Trending now at Annals.org: Development and Evaluation of a Comprehensive Prediction Model for Incident Coronary Heart Disease Using Genetic, Social, and Lifestyle–Psychological Factors: A Prospective Analysis of the UK Biobank: bit.ly/40uUwBG Mayo Clinic

Disclosure of high genetic risk is often associated with no significant measures to mitigate risk Mohammadreza Naderian & I comment on a syst review on behavior outcomes after disclosing CV genetic risk Genetic risk disclosure and behavioural change: not so fast tinyurl.com/mr2zv7yb

🎉 So excited to #MATCH BCM IM Residency and begin my journey as an Internal Medicine resident! Grateful for this incredible opportunity!

Congrats, Mohammadreza (Reza) Naderian !! We're so excited to welcome you to the family. 🥳

In honor of #NationalTriglyceridesDay, read the Joint Consensus from ASPC & National Lipid Association! Recognition and Management of Persistent Chylomicronemia: A comprehensive expert clinical consensus by the NLA & ASPC. ow.ly/NU9g50VqxCE Michael D. Shapiro Christie Ballantyne

We are excited to share our Joint Expert Clinical Consensus with ASPC! To celebrate #NationalTriglycerideDay, check out our article on Persistent Chylomicronemia. Journal of Clinical Lipidology 🔗lipidjournal.com/article/S1933-…

Read the joint consensus from ASPC & National Lipid Association! Published AJPC. Recognition and Management of Persistent Chylomicronemia: A comprehensive expert clinical consensus by the NLA & ASPC. ow.ly/NU9g50VqxCE #NationalTriglyceridesDay Michael D. Shapiro Erin D. Michos, M.D.

MI-GENES randomized patients at intermediate cardiovascular risk to disclosure of framingham risk score 🆚an integrated score also incuding a polygenic risk score (PRS)🧬 Disclosing the PRS led to 👉lower LDL 👉higher statin initiation 👉lower 10-y cardiovascular event rates

Terrific work from Iftikhar J. Kullo. *10y* fu MI-GENES trial (ahajournals.org/doi/10.1161/CI… Circulation) now shows that CAD PRS disclosure vs not on top of clinical risk disclosure for intermediate risk adults leads to reduction in MACE ahajournals.org/doi/10.1161/CI… Circulation: Genomic and Precision Medicine #ACC25 Small trial

Congratulations to Mohammadreza Naderian and Iftikhar J. Kullo on this great work!

Excellent summary of our work led by Mohammadreza Naderian by Marios Georgakis Patients & providers were able to act on an integrated risk score for CHD that included PRS, leading to⬆️in statin use ➡️ lower LDL and ⬇️ CV events More RCTs are needed to assess clinical utility of PRS

🔰 Excited to share our latest manuscript in Circulation: Genomic and Precision Medicine on long term results of the MI-GENES RCT: 💠 After 1️⃣0️⃣ years of follow-up, 🧬PRS disclosure was associated with: ⬇️MACE & CHD symptoms 🫀 ⬆️Statin initiation💊 ⬆️Statin use duration📈 ⬇️LDL-C📉 ahajournals.org/doi/10.1161/CI…

💠 Truly honored to be recognized as the recipient of the ‘Early Career Investigator Award’ 🎖️ from the American College of Physicians ACP & Annals of Internal Medicine Annals of Int Med! 🔶 Grateful for my mentor Iftikhar J. Kullo and my colleagues at Mayo Clinic CV!

From Mohammadreza Naderian & Iftikhar J. Kullo: Effect of Disclosing a Polygenic Risk Score for Coronary Heart Disease on Adverse Cardiovascular Events ahajournals.org/doi/10.1161/CI… AHA Science #AHAjournals #CardioTwitter #Genetics 🎥 Vibhu Parcha