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New article: Whole-genome analysis identifies novel drivers and high-risk double-hit events in relapsed/refractory myeloma link.paperbirds.me/SZzR5F #MMSM #MultipleMyeloma #hematology

"They want us to validate our RNAseq with real-time PCR"

Presenting our recent work on #WGS-based clonal haematopoiesis dynamics at #ASH22. Really happy to see lots of interest!

Get in touch if you’re interested! Great science, friendly and supportive lab, important topics…

Our relapsed/refractory myeloma whole genome paper is now out! Naser Ansari-Pour @mksamur … and thanks for the editorial Alessandro Lagana' MRC WIMM MRC MHU

For a quick overview of our deep WGS rrMM paper (N=418), have a look at this fantastic editorial @BloodJournal. Thanks Alessandro Lagana'! doi.org/10.1182/blood.…

💭Can we learn the lessons of the personalised medicine revolution in solid cancers to improve treatment of multiple myeloma? We must, says clinician scientist Dr Sarah Gooding. Sarah Gooding | MRC WIMM | MRC MHU | Oxford Centre for Haematology Read more: bit.ly/3RQZEM9

#MachineLearning clinical prediction models fail to generalize across trial data, a new Science study finds. The results "require reexamination of the practical challenges that precision medicine is facing." scim.ag/5uM #SciencePerspective: scim.ag/5uL

Fascinating Timelapse of land occupied by Native Americans

Mutational signature analysis has become a key tool for interpreting somatic mutations. Our tool MuSiCal (Mutational Signature Calculator) by the amazing Hu Jin (Hu Jin) and Doga Gulhan (Doga Gulhan) is out at Nat Genetics: nature.com/articles/s4158…. Three key ideas below.

A significant step in the right direction for mutational signature analysis. I was always suspicious of SBS39 and we even touched upon this in our paper (nature.com/articles/s4146…; see excerpt from the paper) due to its high similarity to SBS3!

My annual reminder to please stop using Tophat. Still papers using Tophat v1 (!) from 12 years ago 😱 There have been many better alternatives around for a long time now. Screenshot below is from nature.com/articles/s4139…

Cancer origin tracing and timing in two high-risk prostate cancers using multisample whole genome analysis: prospects for personalized medicine. #BeyondTheAbstract on UroToday > bit.ly/3x5kUHO Tapio Visakorpi Teemu Murtola Naser Ansari-Pour

Just saw our paper on my Google News Feed! Nice 👌🏼