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🦠🧬Smart skin bacteria are able to secrete and produce molecules to treat acne New research by Synbio Lab with Nastassia Knödlseder and Marc Güell manages to edit the genome of Cutibacterium acnes to secrete and produce the NGAL protein to treat acne. 👉🏽 bit.ly/3vtgyZE

Today, we are excited to share with you our most recent work in Nature Biotechnology about domesticating C. acnes, a skin microbe, as a production and delivery shuttle for therapy. Want to know more?🪡🧵

Delivery of a sebum modulator by an engineered skin microbe in mice go.nature.com/47oaNtH

Marc Güell Nastassia Knödlseder Synbio Lab UPF Medicine and Life Sciences IDIBELL Universitat de Barcelona Centre for Genomic Regulation (CRG) ICREA Community Lund University Aarhus University Smart skin bacteria are able to secrete and produce molecules to treat acne #NBTintheNews via UPF Barcelona bit.ly/3vtgyZE

Interesting approach for acne treatment: engineer bacteria to work like Accutane, but locally (and without all the nasty side effects)! Modified C. Acnes bacteria secrete NGAL to kill sebocytes & thus sebum production. They engraft on mice skin & produce NGAL there.

Lovelock-Margulis ideas on the Earth as a self-regulating system can be tested, and we discuss it in our latest paper: A Synthetic Microbial Daisyworld. Jordi Pla, N. Conde Ricard Solé Royal Society Publishing royalsocietypublishing.org/doi/10.1098/rs…

Allying with skin bacteria to treat pathologies 🦠💊 In this short video, researcher Nastassia Knödlseder explains the latest advances in the UPF Medicine and Life Sciences Translational Synthetic Biology Laboratory in the creation of living pills. instagram.com/p/C3VsI3eou1f/

🎓 Eight doctoral students from the PhD Programme in #Biomedicine will receive the UPF Barcelona Doctoral School PhD Extraordinary Award Congratulations to you all! 👏🏽💐💫 Have a look at their projects following this thread 👇🏽 👉🏽tuit.cat/iz7Wy

Can degraded ecosystems facing tipping points be rescued using synthetic biology? In our new paper with victor we show how a new class of "emergent engineering" can do it by havig biodiversity on our side royalsocietypublishing.org/doi/10.1098/rs… Fernando T. Maestre Víctor de Lorenzo Blai Vidiella

Our second book is now available for pre-order. 🎉 Embracing the book's technology theme, we did something special: We encoded the entire book into DNA & packaged it into stainless steel capsules, where it will live for tens of thousands of years. 1,000 copies were made... 🧵

Thank you UPF Medicine and Life Sciences for this recognition!

💡What if bacteria on your skin could be reprogrammed to improve skin health?💡 For scientist Nastassia Knödlseder synthetic biology isn’t just about research – it’s about solving real problems at a microscopic level to improve lives. Read full interview here: tinyurl.com/3h47ryhn

An engineered commensal bacterium delivers brain-targeted therapeutics via intranasal administration in mice. cell.com/cell/fulltext/… #NBThighlight

🚀 Great news for our lab! We’ve received a €2.5M EIC Transition Grant to advance #Synflora, an innovative biotech treatment for acne. By engineering skin bacteria to release beneficial molecules, we aim to revolutionize dermatology! 🔬✨ upf.edu/web/focus/w/sy…