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Cancer organoids 2.0: modelling the complexity of the tumour immune microenvironment dlvr.it/T9N1S4

Published today! We found that cancer cells adapting to drug treatments don't simply switch from a sensitive to resistant state; instead there's a ‘resistance continuum’ of resistant phenotypes with epigenetically reprogrammed states. 🧵⬇️ nature.com/articles/s4158… @Gustavo_SFranca

Muppidi and colleagues find that loss of the G-protein Gα13 suppressed diffuse large B cell lymphoma formation in the mesenteric lymph nodes by limiting the effects of dietary nutrients. Read it here: rdcu.be/dQFmi nature.com/articles/s4159…

Marie and colleagues identify a population of tumorigenic Th17 cells in the intestine. Read it here: rdcu.be/dQFtx nature.com/articles/s4159…

Whole-genome sequencing of more than 2,000 colorectal carcinoma samples provides a highly detailed view of the genomic landscape of colorectal cancer and identifies new driver mutations, according to a paper in nature. go.nature.com/4dgzRGz

A Comment article in Nature Reviews Gastroenterology & Hepatology discusses how the western lifestyles causes metaflammation, which might prime committed cell lineages to initiate colon tumorigenesis. At-risk individuals might include cases of early-onset colon cancer. 🔒 go.nature.com/3WCIBjh

There is an urgent need for more effective strategies to preselect patients for therapies, mitigating the risk of administering ineffective, potentially harmful drugs and speeding up the process for patients to receive the most effective treatment go.nature.com/4cXfuy8

A Review in Nature Reviews Drug Discovery provides an overview of the dynamics of the nerve-cancer cell interplay and discusses the current preclinical and clinical evidence of the benefits of targeting the nervous system in cancer. 🔒 go.nature.com/3XfAjy8

Great turnout at the #CCE Clinical Trials & Translational Research reception in Barcelona! It was wonderful to see the working group come together to connect and network. Many thanks to all attendees ✨ #ESMO24 #ClinicalTrials #CCE_DART #BoBTrial

To celebrate 100+ years of the #WarburgEffect, #Cancer editors from Springer Nature put together a collection of articles highlighting the breadth of #CancerMetabolism research & its potential for the clinic. BMC Cancer at Nature Portfolio Nature Portfolio nature.com/collections/dj…

.Tara Muijlwijk Rieneke van de Ven Amsterdam UMC Cancer Center Amsterdam - Amsterdam UMC characterise a subgroup of copy number alteration-quiet #HeadAndNeckCancer using #genomics #CancerResearch Cancer at Nature Portfolio nature.com/articles/s4146…

Ghosh et al. analyse impact on protein expression, biochemical properties, and evolutionary conservation of all C-terminal nonstop extension mutations registered in the pan-cancer NonStopDB dataset #CancerResearch Cancer at Nature Portfolio nature.com/articles/s4146…

To celebrate 100+ years of the #WarburgEffect, #Cancer editors from Springer Nature put together a collection of articles highlighting the breadth of #CancerMetabolism research & its potential for the clinic. BMC Cancer at Nature Portfolio Nature Portfolio nature.com/collections/dj…

To celebrate 100+ years of the #WarburgEffect,Springer Nature editors put together a collection of articles highlighting #CancerMetabolism research & its potential for the clinic. nature.com/collections/dj… BMC Nature Medicine Nature Reviews Cancer Nature Portfolio

.MáireNíLeathlobhair @mnileathlobhair.bsky.social et al. analyse the genomic landscape of testicular germ cell tumours using WGS data from the Genomics England 100,000 Genomes Project #CancerResearch #testicularcancer #testicularcancerawareness Cancer at Nature Portfolio nature.com/articles/s4146…

The I-SPY trial platform was designed to accelerate development of #neoadjuvant treatments for early-stage #breastcancer and provides a model for future response-adapted clinical trials. News & Views from Javier Cortes MD PhD & colleagues nature.com/articles/s4159…

Shifting from a profit-driven model to one that prioritizes affordability and access to advanced medicines for #patients. A timely and much needed Perspective by Melinda Kliegman and colleagues Institute for Geographic Information Science “A roadmap for affordable genetic medicines” nature.com/articles/s4158… nature

new out in Nature last week nature.com/articles/s4158…

How can you increase the impact of your own research beyond the publication impact factor? 🤔 Our podcast guests @IACR_DIR, Javier Carmona 🇪🇺 & Caroline Dive (CRUK Lung Centre) discuss this in episode 7 of The Cancer Researcher Podcast: magazine.eacr.org/make-your-rese… #CancerResearch

In our latest #JournalClub, Chae & Chung (Seoul National University Hospital) discuss a study characterizing the differentiation & maturation of both tumour-resident and circulating B cells in patients with melanoma. 📖👉bit.ly/4hFLyt4