Looking forward to cutting into this data!

scLong: A Billion-Parameter Foundation Model for Capturing Long-Range Gene Context in Single-Cell Transcriptomics • This study introduces scLong, a foundation model with one billion parameters, designed to capture long-range gene interactions across the entire transcriptome

Great collaboration with George Liu, ᐯIᑕTOᖇ ᑎIᘔET Wan-Tien Chiang and others, figuring out why the Staph vaccine failed! genengnews.com/topics/infecti…

New seminar 🚨 Our next seminar is Monday, Feb. 3 with Dr. Nathan Lewis of UGA Franklin College. We hope to see you there! #UGAVetMed

RESEARCH | Hooman Hefzi, Nathan Lewis and colleagues (DTU, UGA) #Engineering cells with the goal of circumventing #pH and osmolarity issues that arise in #bioreactor-based production of #biopharmaceuticals 🧫 nature.com/articles/s4225…

While our first discovery of this occurred just weeks into the shutdown, it's great to see it off bioRxiv now. SARS-CoV-2 infectivity can be modulated through bacterial grooming of the glycocalyx. Great collab with Knight and Esko labs and many others journals.asm.org/doi/10.1128/mb…

#Biomanufacturing, which uses living cells to produce life-saving #medicines, faces a major hurdle: lactic acid build-up. This waste product limits cell growth and reduces #production efficiency. Now, researchers have developed a groundbreaking genetic technique that stops cells

The federal government doesn’t ‘give’ money to Harvard. The $2.2 billion in frozen payments isn’t for Harvard sophomores’ tuition or library books. The US government is buying services from Harvard: scientific & medical research & development. These aren’t ‘woke donations.’

Excited to present work of a few dozen researchers on the recent community-wide update of the CHO metabolic network. This time we show what can be done when you have the whole "biochem textbook" of the cell... with all the pathways and protein structures biorxiv.org/content/10.110…

I’m happy to share that our scCellFie manuscript is finally on bioRxiv — a project that was an amazing opportunity to return to my roots in metabolism! We infer metabolic activity from single-cell & spatial transcriptomics 🧬 Read the pre-print here👇 📄 doi.org/10.1101/2025.0…

Excitng collaboration in which we expressed a hepatitis c vaccine candidate in a panel of glycoengineered CHO cell lines. This allowed us to find a specific glycan structure that greatly improved immunogenecity, even for more distant strains #glycotime nature.com/articles/s4154…

Honored to have our recent work on mapping out the cell machinery regulating protein secretion highlighted at Genetic Engineering & Biotechnology News genengnews.com/topics/bioproc…

Mapping Out the “Everything” of Protein Secretion The invention of CRISPR and DNA sequencing has provided the necessary tools for rapidly engineering CHO cells along with a parts list Nathan Lewis #CRISPR #DNAseq #proteins hubs.li/Q03F2TSr0

Why do some recomb proteins express better than others? After expressing >2000 proteins from the human secretome in CHO cells, we identified the protein features and host cell pathways linked to poor expression w/ Johan Rockberg lab. pnas.org/doi/abs/10.107…

Congrats to Mina Wu for an excellent PhD defense on improving production of mAbs and vaccine proteins by studying protein-protein interactions in the production cells. See doi.org/10.1002/biot.7… and doi.org/10.1016/j.ymbe…