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Protein Quaternary Structures in Solution are a Mixture of Multiple forms biorxiv.org/content/10.110…

New UniDec version 5.0.3 ready to release in the wild. The most interesting new features are the real time deconvolution experimental features (short thread) and the m/z vs. mass plot for CDMS github.com/michaelmarty/U…

The MASH Team is excited to announce the first version of MASH Native! MASH Native builds upon previous versions of MASH Explorer but also includes new features such as spectral summing, internal fragments, and Unidec deconvolution. Check it out today at: labs.wisc.edu/gelab/MASH_Exp…

Interested in learning how Native MS can help answer structural biology questions? A two-day short course in Native Mass Spectrometry, to be held June 4-5 at ASMS in Minneapolis, is designed to introduce this growing field to new practitioners. asms.org/conferences/an…

Exciting collaboration where we show that HRPF-guided Rosetta structure elucidation is successful in a true blind prediction scenario.

Our review article in Annual Reviews of Physical Chemistry is out! We are summarizing computational work that is using mass spectrometry data for protein structure determination. With particular focus on chemical cross-linking, HDX, HRPF, IM, and SID. annualreviews.org/doi/10.1146/an…

Congrats to Marius Kostelic and Jason for their new paper in J. of the American Society for Mass Spectrometry! They discovered that PEG coating improve sensitivity of native MS, especially of AAV capsids. Awesome work from the team @ErinBakerNCSU Craig Aspinwall Jack Ryan @henrymsandersg1! pubs.acs.org/doi/full/10.10…

Check out these Resource presentations by the Wysocki group and Russell group at ASMS 2022 nativems.osu.edu/node/505

Our most recent SID modeling work is now out. In a collaboration with the @WysockiVicki Lab, we use structures of protein complexes to predict SID breakage profiles. The new method is available in Rosetta. Native MS-Guided Structural Biology Center pubs.acs.org/doi/10.1021/ac…

Now available in Nature Communications: our most recent work using ion mobility mass spec data to elucidate protein tertiary structure. Exciting collaboration with @WysockiVicki and the Prell Lab. Native MS-Guided Structural Biology Center nature.com/articles/s4146…

Give our new MASH Native page a follow for exciting updates to our FREE MS processing software that can process ALL types of native MS data!

Excited to share our latest cooperativity story. We quantified the ligand binding cooperativity in cyclic homo-oligomers via Native MS and mechanistic modeling. One of the proteins has about 30 times higher cooperativity than hemoglobin! Native MS-Guided Structural Biology Center Ohio State Chemistry and Biochemistry

Excited to work on this collaboration with The B-HIVE Center and Native MS-Guided Structural Biology Center

Webinar: Native Mass Spectrometry for Structural Biology via proteinsociety mailchi.mp/proteinsociety…

Breaking a big problem into smaller pieces and solving them one by one is a good strategy for designing a protein (and navigating life in general). Check out the bioRxiv where we apply this idea to designing pseudosymmetric hetero-oligomers! biorxiv.org/content/10.110…

In this paper, we pseudosymmetrized two de novo designed homo-oligomers. For the first, BGL0 (pronounced “bagel zero”), we worked worked with Native MS-Guided Structural Biology Center and SAXSatSIBYLS to verify that 10 of the 20 redesigned homotrimers assemble properly

Check out our latest paper 📚🔬 on predicting collision cross section (CCS) from protein structures through a user-friendly, free-to-use webserver, ROSIE-PARCS. We hope ROSIE-PARCS can help mass spectrometrists with their CCS predictions! doi.org/10.1093/bib/bb…

Join Thermo Fisher and Native MS-Guided Structural Biology Center on January 16 to highlight the complementarity of native mass spectrometry and cryoEM 🎉 To register, visit forms.office.com/Pages/Response…