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Research| Leblanc et al. analysed transcriptomic data from atrial fibrillation patients and controls, finding a dysregulation of the IFNG locus and androgen receptor signaling in cardiomyocytes and identifying a role for NR4A1 regulation in fibroblasts. 👉rdcu.be/efly2

Research| Li, Ni, Wang et al. identify CD248+ fibroblasts as key players in cardiac fibrosis, promoting fibroblast-T cell interactions. Disrupting CD248-mediated pathways shows promise in reducing fibrosis and improving heart function. 👉rdcu.be/efPj0

We highlight the study by Marcus et al. in Circulation, where the authors showed that a transseptal approach to catheter ablation can maintain the procedure’s anti-arrhythmic benefits while reducing brain damage. 👉rdcu.be/egl4s

Research| Jimenez et al. show that CD40 agonists can induce myocardial inflammation by activating cardiac macrophages and CD8 T cells, sensitizing the heart to secondary injury and promoting adverse remodeling. 👉rdcu.be/ehHlK

❤️Our April issue is out❤️ Read about sex differences in atherosclerosis revealed by single-cell sequencing, how cardiac motion can be generated from electrocardiogram readings, the cardiac side effects of targeting immune checkpoint regulators, and more! nature.com/natcardiovascr…

Research| Qi et al. show that bile acids produced by the gut microbiota can suppress platelet activation and reduce atherothrombosis, protecting atherosclerotic mice from myocardial ischemia-reperfusion injury. rdcu.be/eiiQf

Research| Li et al. present a spatially resolved atlas of human atherosclerotic plaques, revealing cellular heterogeneity and identifying lymphoid structures within the plaques and their potential functions and implications. doi.org/10.1038/s44161… rdcu.be/ejPd5

Research | Fan, Zheng, Zhan, Xu, Liu et al. reveal that the RNA-binding protein ARID5A drives inflammaging through the NF-kB-TBK1 pathway, and inactivating myocardial ARID5A attenuates cardiac senescence and functional decline. doi.org/10.1038/s44161… rdcu.be/ej7ww

Review | Fankhauser et al. provide an in-depth review of preclinical mouse models used to study immune checkpoint inhibitor-associated myocarditis and discuss potential improvements to the field to strengthen our understanding. doi.org/10.1038/s44161… rdcu.be/ek2Dh

Research | Ling, Liu, and colleagues introduce MSR, a multiscale recursive algorithm that enhances cardiac microscopy for precise cardiovascular signal extraction, and validate the approach in vitro and in vivo. doi.org/10.1038/s44161… rdcu.be/elnFv

Research| Sadhu et al. identify and functionally validate ferredoxin-1 (FDX1) as a determinant of cholesterol metabolism and cardiovascular risk in Asian populations. Nilanjana Sadhu LKCMedicine Research LKCMedicine doi.org/10.1038/s44161… rdcu.be/el1Xr

Research| Adamopoulos, Rovas et al. show that high regional wall shear stress correlates with fibrosis and left atrium electrical scarring in patients with atrial fibrillation, providing insight into the development of fibrosis. doi.org/10.1038/s44161… rdcu.be/emh6y

Research| Qian, Ugurlu, Fairweather, et al. generate more than 3800 #CardiacDigitalTwins from imaging and ECGs to reveal electrophysiological insights and their links to cardiac function, lifestyle, mental health and clinical outcomes. rdcu.be/em0NT

Research | Lei et al. show that cold preservation of heart transplants triggers mineralocorticoid receptor clustering in cardiomyocyte nuclei, and blocking this improves heart transplant function. doi.org/10.1038/s44161… rdcu.be/enbAz

Research | Kraft et al. identify TIE2 activation as a key driver of PI3KCA-related venous malformations and demonstrate that inhibiting TIE2 signalling can suppress the growth of advanced lesions. doi.org/10.1038/s44161… rdcu.be/en0hU

Research| Case et al. report that low-dose interleukin-2 clonally expands Tregs and maintains their suppressive program by bypassing BACH2 downregulation in patients with acute coronary syndrome from the LILACS trial.Mallat_Lab Tian Zhao Ziad Mallat rdcu.be/ephaW

Research| Wang, Tang et al. develop an iterative random forest pipeline to investigate epistasis in the genetic control of cardiac hypertrophy, identifying epistatic variants near the CCDC141, IGF1R, TTN, and TNKS loci. doi.org/10.1038/s44161… rdcu.be/epB59