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[PUBLICATION] Treating patients with somatic PIK3R1 mutations using alpelisib leads to clinical and radiological improvement. A promising step toward targeted therapy in PIK3R1-related disorders. 📄Read more: embopress.org/doi/full/10.10… Guillaume Canaud (MD, PhD) Gabriel Morin EMBO Mol. Medicine

🚨 We're hiring! The IMMEDIAB Lab team is looking for: 🧪 1 Postdoc 🧬 1 Research Assistant / Bioinfo/ Tech 📍 Paris | Start Sept 2025 📄 Full details + apply: institut-necker-enfants-malades.fr/careers Dr. Fawaz Alzaid

🗓️ Join us on Friday, June 6, for a #seminar with Elvira Mass, Head of the Department of Developmental Biology of the Immune System at LIMES Institute Bonn. Prof. Mass will explore the developmental programming of tissue-resident macrophages. Don’t miss it! Nicolas Venteclef IMMEDIAB Lab

🗓️ Join us on June 13, for a #seminar with Han Li, Principal Investigator and leader of the cellular plasticity in age-related pathologies group at Institut Pasteur. Prof. Li will explore senescence induced-cellular plasticity in health & disease. Don’t miss it! Pende Mario

🚨 We're hiring at INEM! The Immunity in Health and Disease team, led by Simon Fillatreau, is recruiting: 🔬 Assistant Engineer 🧑‍💼 Horizon Europe Project Manager (ARTiDe project) More info & how to apply: 🔗 institut-necker-enfants-malades.fr/offre-demploi/… 🔗 institut-necker-enfants-malades.fr/offre-demploi/… Inserm

🗓️ Join us on June 20, for a #seminar with Jean-Emmanuel Sarry Sarry Lab, team leader at CRCT-Oncopole. Dr. Sarry will explore Mitohormesis and metabolic adaptations in response to therapeutic stress in acute myeloid leukemia. Don’t miss it!

[PUBLICATION] First report of successful pregnancies after treatment with alpelisib for PIK3CA-related overgrowth spectrum. ➡️Fertility preserved ➡️No embryotoxicity ➡️Disease remained responsive after treatment pause 📖Details here: nature.com/articles/s4143…

[PUBLICATION] mTORC1 governs multiciliated cell differentiation by favoring progression through a cell cycle variant without DNA replication and by acting on cytolinker proteins for centriole disjunction. 📖Read more: embopress.org/doi/full/10.10… Pende Mario

🗓️ Join us on July 4, for a #seminar with David Sabatini, group leader at IOCB Prague. Dr. Sabatini will explore nutrient sensing by the mTOR pathway. Don’t miss it! Pende Mario

[PUBLICATION] PIK3CA mutations in Schwann cells trigger neuropathy by disrupting nearby healthy tissues. This non-cell autonomous effect shifts local metabolism toward aerobic glycolysis. Early alpelisib treatment is key | PNASNews 🔗pnas.org/doi/10.1073/pn… Guillaume Canaud (MD, PhD)

[PUBLICATION] New study with the Bharat lab MRC-LMB Cell Biology reveals the structure of the Neisseria meningitidis filamentous phage MDAΦ. Cryo-EM/ET show how phage bundling supports biofilm formation & pathogenesis. Mathieu Coureuil PNASNews pnas.org/doi/10.1073/pn…

🚨 We're hiring! INEM is recruiting a Group Leader in #Immunology. Join a vibrant biomedical research institute with strong clinical & academic links. 🗓 Apply by Sept 20, 2025 🔗 More info: institut-necker-enfants-malades.fr/careers

[CAREER] A 3-year PhD position is open in Paris to explore how air pollution contributes to CKD. The project combines experimental and environmental science and is hosted by INEM & LISA. 📨 Apply by Sept 1. 🟢 Start Nov–Dec 2025. institut-necker-enfants-malades.fr/offre-demploi/…

#France2030 | Félicitations à Guillaume Canaud Guillaume Canaud (MD, PhD), lauréat d’une Chaire d’excellence en Biologie/Santé pour son projet sur les malformations vasculaires liées à KRAS. 🎯Objectif : développer des thérapies ciblées pour une médecine ultra personnalisée. 👏🏼

🎉 Congratulations to Juliane Da Graça, recipient of the 2025 Beth Levine #ThesisPrize! Her outstanding research Morel Lab🇪🇺 on the role of ER/Endosome contact sites in the regulation of #autophagy captures the award's spirit of excellence and innovation. 👏

👏🏼 Proud to see Juliane Da Graça, former PhD student at INEM, honored with the 2025 Beth Levine Thesis Prize for her outstanding work on autophagy, supervised by Etienne Morel Morel Lab🇪🇺.

[PUBLICATION] NEW in Cell Reports Juliane Da Graça et al. show that ER-endosome contacts act as hubs for phagophore formation during starvation. 📖 cell.com/cell-reports/f… Morel Lab🇪🇺

[PUBLICATION] The Morel Lab🇪🇺 shows how Influenza A virus rewires ER lipid metabolism to promote viral ribonucleoproteins egress. 🦠 📖 journals.plos.org/plosbiology/ar… Carla Alemany Juliane Da Graça sharing the first authorship 👏🏼 w/ Institut Pasteur, since 1887 & IPNP PLOS Biology