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Two cardiac myosin inhibitors in the treatment of obstructive hypertrophic cardiomyopathy cell.com/med/fulltext/S…

Happy to share my newest publication is now available here: pnas.org/doi/10.1073/pn… Using in vitro reconstitution assays and in silico modeling, we describe the mechanism by which kinesin-1 teams move lipid-based cargoes through 3D microtubule intersections.

#ArticlesInPress: Proteolytic degradation of atrial #sarcomere proteins underlies contractile defects in #atrial fibrillation Hannah E Cizauskas et al. ow.ly/MsQm50SFhRr Jonathan Kirk Dave Barefield, PhD Loyola University Chicago #AtrialFibrillation #AtrialContractility #AtrialStunning

If Kamala wins, I will have experienced 3 different administrations all while in grad school…..let me graduate

Exciting new work by Angie Greenman showing Autoinhibition of cMyBP-C by its middle domains biorxiv.org/content/10.110…

I used to walk 2.5 km (one way) from Andheri Station to my office every single day. It took me roughly 30 minutes, and by the end of it, I used to get completely drenched in sweat thanks to the notorious Mumbai humidity. I needed to carry a separate shirt with me because I

This is a great plan if the NIH wants to discourage people who are changing fields, taking on ambitious projects, or have any chance of family life disrupting their postdoc

It's amazing how cordial and kind a critic can be in a face-to-face private conversation (eg. offering feedback after a seminar when others are *not* watching), and how the language changes to almost performative insults, as soon as that same otherwise-kind person goes on twitter

Such a nice opinion piece by Thirumala-Devi Kanneganti Kanneganti Lab covering our publication on Pyroptotic secretome! nature.com/articles/s4142…

Kristina Kooiker et al University of Washington investigate a novel cardiac #myosin inhibitor that depends on the presence of a myosin regulatory light chain (RLC-1). They show that RLC-1 destabilizes myosin interactions to inhibit force & accelerate kinetics in cardiac muscle hubs.la/Q02Jz4Sn0

Our new publication in Journal of General Physiology investigating mechanism of a novel myosin inhibitor! Michael Regnier MuscleX_Lab UW Center for Translational Muscle Research UW Bioengineering

Thank you Neural Cell News for highlighting our work!

Two recent reports from the lab: doi.org/10.7554/eLife.… and pubs.acs.org/doi/full/10.10…. Cells continually break down proteins using the proteasome machinery. The Fat10 protein attaches to other cellular proteins, marking them for breakdown by the proteasome. 1/4

Very excited to share that the final manuscript of my first-author publication "Dilated cardiomyopathy mutation in beta-cardiac myosin enhances actin activation of the power stroke and phosphate release" is now available online at PNAS Nexus! doi.org/10.1093/pnasne…

🚨Announcement🚨 The BCVS Mentorship Program is taking applications for Trainees looking to gain experience in the lab of established and leading investigators in cardiovascular research. Apply here for this unique and exciting opportunity! professional.heart.org/en/professiona…

Prof. Jayant Udgaonkar from #IISERPune among those selected for the 2024 Vigyan Shri Awards, which are part of the new Rashtriya Vigyan Puraskar awards initiated by the Government of India #Congrats to Prof Udgaonkar on this recognition! iiserpune.ac.in/news/post/vigy…

I am happy to announce that I will start my own lab at FMI science Basel in Dec2024 focused on using live-imaging to understand how growth signals modulate metabolism in vivo to drive specific cell fate decisions- in homeostasis and deviations caused by oncogenic mutations. 1/6

I give the same advice (for free, so take it or leave it) every time: read widely When you read a paper that makes you wish you’d written it, for whatever reason, write down the lab (and the first author if they’re a postdoc). With that list, ask around to filter Then reach out

Proud moment for the lab IISER Pune !!!

#Congrats to Prof Jayant Udgaonkar on receiving #VigyanShri Award from Honourable President of India Droupadi Murmu President of India! #MomentofPride for us all at #IISERPune Congrats to all awardees on this recognition for distinguished contributions to science and technology👏👏