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The Brotherhood. #RepBX

We are delighted to share our latest findings today in nature. We describe cardiogenic regulation of sleep after cardiac injury. “Myocardial infarction augments sleep to limit cardiac inflammation and damage” nature.com/articles/s4158…

We find that atherosclerosis, heart failure, and myocardial infarction (MI) profoundly augment sleep. MI elicits a significant increase in slow wave sleep pressure, drive, and abundance after infarct. Increased SWS comes at the expense of REM and wake time. How does this happen?

After MI, microglia recruit monocytes to the brain’s thalamus via the choroid plexus and 3ed ventricle. Once in the lateral posterior nucleus of the thalamus, monocytes gain the capacity to produce TNF which engages a subset of glutamatergic neurons to instigate a sleep circuit.

Increased sleep after MI is beneficial. In mice, fragmenting sleep after an MI worsens cardiac inflammation and damage. Sleep and TNFR1+ thalamic neurons limit sympathetic outflow from the brain to the heart, curtailing cardio-inflammation in a macrophage ADRβ2-dependent manner.

In humans, poor sleep in the weeks following STEMI or NSTEMI associates with reduced cardiac recovery and function and increases MACE+ incidence over 2 years. Further, sleep restriction in humans causes inflammatory and chemotactic reprograming of ADRβ2-responsive monocytes.

In summary, MI elicits monocyte recruitment to the brain’s thalamus to increase sleep which promotes cardiac healing and recovery. This study was driven by a fantastic lab team including Pacific, Jan, and Teresa, and would not have been possible without wonderful collaborators!

A new heart-brain-immune system discovery Following damage to the heart muscle from a heart attack, monocytes are recruited to the brain to promote sleep, limit inflammation, and healing. nature.com/articles/s4158… @peacemakerhuynh Cameron McAlpine Icahn School of Medicine at Mount Sinai Cardiovascular Research Institute at Sinai (CVRI)

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New Mount Sinai research reveals that a #HeartAttack can trigger a desire to get more #sleep, allowing the #heart to heal and reduce inflammation—and this happens because the heart sends special signals to the #brain. Learn more: mshs.co/3AmcAor Mount Sinai Department of Medicine

Excited to speak on Sleep and Women’s Health at the Icahn School of Medicine at Mount Sinai 2nd Annual OB/GYN Women’s Health Forum to expand knowledge, empower patients & connect with experts on women’s health. Register today! shorturl.at/KDQGZ

Gorgeous day for football! New York Giants

New ⁦⁦⁦American Thoracic Society (ATS)⁩ workshop exploring the links between #osa and #cvd. One thing is clear: OSA is not a single disease entity! Co-chairs ⁦⁦⁦⁦⁦⁦Neomi Shah⁩ Klar Yaggi ⁦⁦Vaishnavi Kundel, MD, MS⁩ atsjournals.org/doi/10.1513/An…

Beyond THRILLED to share that our team’s #research proposal to conduct a study on #Menopause-Associated #Insomnia Treatments has been approved for $14.1M in The Patient-Centered Outcomes Research Institute funding! Learn more: pcori.org/research-resul… #CER  Susan Redline Kelly Baron, PhD, MPH, DBSM Katie Sharkey MD PhD (she/her) Heather Baer...

nytimes.com/2024/12/19/wel… via @NYTimes Great insights from ⁦Oren Cohen⁩ featured in the article ‘How to Actually Sleep on an Airplane.’ Practical tips! ✈️ ⁦Mount Sinai Department of Medicine⁩ ⁦ATS Early Career⁩ ⁦ATS Early Career⁩ ⁦AASM Foundation⁩ ⁦