We ⁦Neyts Virology Lab⁩ show omicron #SARSco2 does not readily infect lungs of hamsters (contrast to other strains). Reasons may be 1) too well adapted to man 2) infects rather the upper respiratory tract 3) is less pathogenic or, combination of above. biorxiv.org/content/10.110…

Check our study Neyts Virology Lab KU Leuven in which we demonstrate that the antiviral drugs approved to treat #COVID19 are equipotent against the different variants, including omicron. biorxiv.org/content/10.110…

Proud Neyts Virology Lab contributed to study ⁦The Veesler Lab⁩ Vir Biotechnology ⁦Science Magazine⁩ on potent/broad SARS-CoV2 antibody. Good candidate for development. May also help to develop broader corona (sarbeco)vaccines.Highlight in ⁦nature⁩ nature.com/articles/d4158…

Check our manuscript Neyts Virology Lab in which we report on the fact that hamsters cannot be readily infected with omicron, which is in stark contras to what is observed with other variants. sciencedirect.com/science/articl…

An interesting read on the need and the challenges to develop broadly acting potent #sarscov2 vaccines that should also result in a long-lasting immune respons/protection. Not a simple task. Still important gaps in our knowledge. ⁦The Washington Post⁩ washingtonpost.com/health/2022/02…

Interesting read on the power/versatility of the mRNA vaccine technology for #sarscov2 & other indications. Also constraints on IP, raw material, high cost, need for strict cold-chain limiting the use in low-middle income countries. ⁦Nature Reviews Microbiology⁩ nature.com/articles/d4157…

Check our paper Neyts Virology Lab in Nature Communications in which we demonstrate that the oral protease #SARSCoV2 inhibitor (PF-07321332 #Paxlovid) completely protects hamsters against various variants and prevents transmission to untreated co-housed sentinels. nature.com/articles/s4146…

Our team is present at #liveICAR2022, the international conference for antiviral research, in Seattle! #NeytsLab #lab #antivirals #vaccines #virus #virology #viral #microbiology #science #medicine #Leuven #Belgium

Our team is present at #liveICAR2022, the international conference for antiviral research, in Seattle! #NeytsLab #lab #antivirals #vaccines #virus #virology #viral #microbiology #science #medicine #Leuven #Belgium

Glad that Neyts Virology Lab ⁦KU Leuven⁩ contributes with ⁦Aligos Therapeutics⁩ and CD3 to the development of a highly potent inhibitor of #sars-cov2 (targeting the viral protease) for the oral treatment and prevention (without ritonavir) of #covid-19 investor.aligos.com/news-releases/…

Check our paper Neyts Virology Lab : the anti-HIV drugs Lopinavir/Ritonavir & Nelfinavir result in a marked improvement of #SARSCoV2 induced lung pathology in the hamster infection model (without an antiviral effect). Further clinical trials warranted.   sciencedirect.com/science/articl…

Tijdens de pandemie werden wereldwijd minder kinderen ingeënt tegen kinderziektes zoals #polio De Standaard Maxie Eckert Polio kan/moet worden uitgeroeid. Wij Neyts Virology Lab werken aan een krachtige poliovirus-remmer als extra wapen in de polio-endgame. standaard.be/cnt/dmf2022041…

Pleased Neyts Virology Lab Piet Maes Sam Van Campenhout contributed to this The Veesler Lab study. An ultrapotent pan-variant antibody, unaffected by any Omicron lineage, was discovered. An ideal candidate therapeutic antibody for the treatment of COVID19 (1/2) biorxiv.org/content/10.110…

Brincidofovir (TEMBEXA®) FDA-approved & EMA orphan designation for treatment of smallpox. Also effective in experimental models against monkeypox. Glad we laid KU Leuven almost 20 years ago the basis for this drug with the discovery of the anti-pox virus activity of cidofovir.

Tecovirimat (Tpoxx®) (Siga Technologies) is FDA and EMA-authorized for the treatment of poxvirus infections, including monkeypox. My team KU Leuven was the first to demonstrate (in 2005) -together with Viropharma - activity of the drug against poxvirus infections in an animal model.

Heldere toelichting door ⁦Marc Van Ranst⁩ ⁦VRT NWS⁩ over #monkeypox #apenpokken vrt.be/vrtnws/nl/2022…

Boeiend bezoek aan #RegaInstitute ⁦KU Leuven @mit_kuleuven, dank voor de hartelijke ontvangst prof. Johan Neyts! Be prepared for the expected unexpected. Nieuwe geneesmiddelen en vaccins redden levens. Alle steun aan dit levensreddend werk.

Het was een grote eer minister Petra De Sutter - naast politica ook arts en wetenschapper - te mogen ontvangen #RegaInstitute KU Leuven Een boeiende discussie over (virale) infectieziekten en “pandemic preparedness”. Zeer motiverend bezoek voor gans het team Neyts Virology Lab

Check our paper Neyts Virology Lab KU Leuven in JVirology Editors in which we report on a robust #SARSCoV2 infection model in SCID #mice that is ideally suited to assess efficacy of small molecule #COVIDantivirals pubmed.ncbi.nlm.nih.gov/35924921/

To study Rift Valley fever virus (RVFV) #riftvalleyfevervirus pathogenesis & develop inhibitors we established an infection model in #zebrafish. RVF is a World Health Organization (WHO) listed priority disease, it causes #haemorrhagicfever , #encephalitis and #blindness. biorxiv.org/content/10.110…