This is a cautionary tale of how anti-Spike antibody may make COVID disease worse. In this study, the authors show that anti-Spike IgG made SARS-CoV disease worse by switching macrophage from wound-healing to proinflammatory phenotype. A thread (1/n) insight.jci.org/articles/view/…

Joe Joseph Sun Lab is a great scientist and even better mentor. I am so grateful for the opportunity I had to work with him, and for the influence he's had on my academic career.

It was great working with Simon Grassmann 草人 (learning Mandarin ;)) and Joseph Sun Lab on this review for Nature Rev Immunol ! We discuss evidence for NK cell clonal expansion, and its molecular requirements and heterogeneity, in comparison with CD8+ T cells

Wondeful advance from @OSullivanLab: optimal electroporation conditions for high-efficiency cRNP gene deletion in primary mature mouse innate immune cells --> gene function of NK cells and cDC1s in vivo (ad tx) during MCMV infection. cell.com/cell-reports/f…

Nice work by my fellow Reizis labmate Chetna Soni revealing mechanisms that promote anti-DNA responses in lupus! 👏

Please RT! I am looking for an enthusiastic postdoc to work on projects in my lab focused on dissecting and restoring tumor suppressive pathways for cancer immunotherapy using cool mouse model approaches in a fun and collaborative scientific environment. umassmed.edu/mccb/faculty-M…

Congrats Gabi, Clair Clair Geary, PhD, and Joseph Sun Lab ! 🎉

Glad to be part of this amazing work w/ Aaron Ring, Ting Zhou William Damsky MD, PhD Marcus Bosenberg. We engineered a designer IL-18 that is resistant to its high-affinity decoy receptor, IL-18BP, and can mediate potent anti-tumor immunity. Check out this twitterorial describing what we did:

Thankful to Damon Runyon Cancer Research Foundation for supporting my research, and honored to be a new Fellow along with these talented scientists!

Want to learn about NK cells and viruses that come from animals? Check out the review that Joseph Sun Lab and I wrote! (Yes, we do talk about Covid 😅) authors.elsevier.com/c/1bYFM6hO9tNe…

It is a pleasure to announce the launch of the Translational Immunology Center at NYU Langone Health. Excited to have as the Leader, one of our own #NYUPathology, Dr. Boris Reizis. The Center will build on the breath, depth and long tradition of immunology at our Institution. 1/3

Check out our latest paper from Joseph Sun Lab on Cell Reports! Here, we show that NK cell adaptive responses are dependent on the antiviral activity of CD8+ T cells. /(1) cell.com/cell-reports/f…

BREAKING NEWS: The 2020 #NobelPrize in Physiology or Medicine has been awarded jointly to Harvey J. Alter, Michael Houghton and Charles M. Rice “for the discovery of Hepatitis C virus.”

Beautiful new work from my friend Simon Grassmann 草人 (learning Mandarin ;)), now out in Nature Immunology! Potential of a T cell family for an inflationary antiviral response is determined early by its composition of central memory precursors

Its been an honor to learn about the immune system and publish our findings with fantastic grad students Nick Adams (now a postdoc at NYU) and Carlos Diaz-Salazar (soon-to-be postdoc at Columbia). Congrats on your final paper with me - now in press! jimmunol.org/content/early/…

So happy that our work on uterine NK cell differentiation is published Science Immunology! Thanks to all involved!! Jonna Bister Dr Iva Filipovic Egle Kvedaraite Antonio Lentini Björn Reinius Tim Willinger lab Russell Hamilton @drrshamilton.bsky.social Martin Cornillet, PhD and many more :) immunology.sciencemag.org/content/6/56/e…

Congrats Kathy and good luck! You'll be fantastic for our MD-PhD program.

Check out this excellent summary by Aleksandra Galitsyna describing the collaborative effort between the Reizis and Leonid Mirny labs! We reveal an essential role for cohesin-mediated chromatin organization in cDC development and function, and its bi-directional crosstalk with IRF8