Spatial-DMT is now published in nature ! For the first time, we can simultaneously map DNA methylation and RNA transcription in tissue context. Great collab with Wanding Zhou lab. Big congrats to Chin Chin , Hongxiang Hongxiang Fu and team! nature.com/articles/s4158…

In the latest issue! Senescence-resistant human mesenchymal progenitor cells counter aging in primates dlvr.it/TMv4Qs

Biomarker-related phospho-tau217 appears in synapses around Aβ plaques prior to tau tangle in cerebral cortex of preclinical Alzheimer’s disease Cell Reports cell.com/cell-reports/f…

Astrocytes mobilize a broader repertoire of lysosomal repair mechanisms than neurons | bioRxiv. Exciting work from @madaylab! biorxiv.org/content/10.110…

In the latest issue! Single-cell multiregion epigenomic rewiring in Alzheimer’s disease progression and cognitive resilience dlvr.it/TMyNCf

Ambient Air Pollution and the Severity of Alzheimer Disease Neuropathology jamanetwork.com/journals/jaman…

ABCA7 variants impact phosphatidylcholine and mitochondria in neurons nature.com/articles/s4158… nature

Neurons sequester the cholesterol-inhibiting TFEB in oligodendrocyte cytoplasm to safeguard myelination and neural function dlvr.it/TN1B6G

Coordination of autophagosome closure and release by the Alzheimer’s disease-associated protein BIN1 dlvr.it/TN2SpT

Targeted degradation of pathologic tau aggregates via AUTOTAC ameliorates tauopathy biorxiv.org/content/10.110… #biorxiv_neursci

Clearing truncated tau protein restores neuronal function and prevents microglia activation in tauopathy mice: Cell Reports cell.com/cell-reports/f…

Wonderful to see our paper on the #organelle signatures of #neurons and #astrocytes out in final form - congratulations Shannon Rhoads and team! 🎉doi.org/10.1016/j.celr…

In the latest issue! Deconstructing the intercellular interactome in vascular dementia with focal ischemia for therapeutic applications dlvr.it/TN9ZsT

Multiscale proteomic modeling reveals protein networks driving Alzheimer’s disease pathogenesis: Cell cell.com/cell/fulltext/…

'#Autophagic impairment in #sleep–wake circuitry is linked to sleep loss at the early stages of #AlzheimersDisease' Christopher Daniel Morrone, Arielle A. Tsang, W. Haung Yu University of Toronto CAMH Research …arneurodegeneration.biomedcentral.com/articles/10.11…

Our RAEFISH spatial transcriptomics technology is now published in Cell Cell! RAEFISH enables sequencing-free whole genome spatial transcriptomics at single molecule resolution. This work represents the first time that transcripts from more than 23,000 genes were

We are excited to share our latest publication “Genetic and proteomic analysis identifies BAG3 as an amyloid‑responsive regulator of neuronal proteostasis" in Acta Neuropathologica this week! Congratulations Zack Augur!! link.springer.com/epdf/10.1007/s…

Microglia-specific regulation of lipid metabolism in Alzheimer’s disease revealed by microglial depletion in 5xFAD Mice nature.com/articles/s4146…

New work from the lab shows that a novel non-coding RNA, FAM151B-DT, is a driver of tau and alpha-synuclein aggregation ⁦WashU Medicine⁩ ⁦The Rainwater Charitable Foundation⁩ ⁦WashU Medicine Knight ADRC⁩ nature.com/articles/s4138…

Our glial circadian atlas in AD and aging mice is now out in Nature Neuroscience! Congrats to Pat Sheehan for incredible work and to our collaborators John Fryer, PhD, Dougherty Lab WashU, Darshan Sapkota, Ron Anafi, and the team. John Fryer, PhD and I started this in 2019! nature.com/articles/s4159…