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MHC Hammer reveals genetic and non-genetic HLA disruption in cancer evolution Charles Swanton Nicholas McGranahan and TRACERx team nature.com/articles/s4158…

Keen to do a computational PhD? Are you of black heritage? Charles Swanton and I have a very exciting project exploring somatic evolution and beyond! Join the CRUKCOLcentre Black Leaders in Cancer programme. Please RT! 🖥️🦀🧪🥼

Applications are open for our Black Leaders In Cancer PhD 2025! We caught up with Lynette Graver who joined the programme this year. Explore projects and apply by noon, 5 November: shorturl.at/5FCJ5 Read more about Lynette's work: shorturl.at/kRcnR BlackinCancer

It was a lovely #YS2C conference at Université de Montpellier. The committee thanks all the keynote speakers: Nicholas McGranahan (@embo young investigator lecture), Mara Sherman Lab, Frances Balkwill, Thommen Lab, Charles Herbaux, Inma Martínez-Reyes, and Joanne Clancy. More info ⬇️ 1/10

If you are in London for #MAP2024, please join our YO Vesalius talk about managing work, research and life! We will wait for you with a Fantastic faculty Nicholas McGranahan Elli Papaemmanuil, PhD MarleenKokLab Joaquin Mateo in the Foyer at 12.15 today! ESMO - Eur. Oncology Emre Kocakavuk, MD, PhD

🚨 Exciting opportunity for oncologists interested in PhD ‘Deciphering LIMD1s impact on lung cancer progression and therapeutic response using novel conditional mouse models’ with Tyson V. Sharp (Barts and The London, Queen Mary ) Nicholas McGranahan UCL and myself. colcc.ac.uk/2025-mbphd-pro… ⬇️

Thrilled to share our paper published in nature, where we uncover a new process of tumor initiation through a polyclonal-to-monoclonal transition at the @precancerous stage. So proud of my fantastic team (led by Zhaolian Lu ) and incredible collaborators! nature.com/articles/s4158…

Extremely proud to see my PhD project exploring intra-tumor heterogeneity in complex karyotype AML finally out in Nature Genetics ! 🎉👩🏻‍🔬 They say that 10,000 hours make you an expert, so I guess after more than five years of work I’m half-way there 😅 ⬇️1/5 nature.com/articles/s4158…

It’s been a long time coming…#PhDone

Kicking off the new year, our paper by Leo Speidel et al. is out describing what to me is a breakthrough in ancient genomics. By using genealogies to study ancestry we can get much more resolution to study finer-scale history. We call this method Twigstats.

Read the In the Spotlight commentary "MHC-Hammer decodes HLA disruption in tumors" brnw.ch/21wQwyh By Timothy Sears and Hannah Carter discussing a recent Nature Genetics paper by Nicholas McGranahan Charles Swanton et al.

Clonal driver neoantigen loss under EGFR TKI and immune selection pressures nature Swanton Lab Quezada Lab Nicholas McGranahan James L Reading Maise Al Bakir nature.com/articles/s4158…

Very proud of Bobby Bentham and his excellent new tool…we’ve been working on this for a while, very much hope it’ll be useful.

An important new tool from Bobby Bentham & Nicholas McGranahan enabling inferring T & B cells from genetic sequencing data now published in Nature Genetics!

New online! Integrating model systems and genomic insights to decipher mechanisms of cancer metastasis bit.ly/3XC0xvy

🔥New #review out! We explore how experimental models and high-throughput sequencing (or, all the ✨#omics✨) complement each other in #metastasis research. Bridging these approaches can unlock deeper insights into #cancer progression and #treatment

Thanks to Cancer Research UK for featuring our work on stem cell plasticity in CRC: news.cancerresearchuk.org/2025/05/09/ste…