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I ricercatori hanno anche sviluppato un nuovo algoritmo che ha migliorato il processo di ricostruzione dell’identità genetica delle cellule profilate, rendendo più accurata l’analisi dei mosaici aboutpharma.com/scienza-ricerc…

The team of Giuseppe Testa have developed methods for multiplexing cortical organoid development to trace neurodevelopmental trajectories at high resolution and at scales. They report SCanSNP, an algorithm to deconvolve cell identities. nature.com/articles/s4159…

I am happy to share our new work investigating neurodevelopmental trajectories by multiplexing iPSC into chimeric brain organoids!

Multiplexing cortical brain organoids for the longitudinal dissection of developmental traits at single-cell resolution | Nature Methods nature.com/articles/s4159…

The Cold Spring Harbor Laboratory conference on neural stem cell models and human development coincides this year with the publication of a consortium effort in nature. This article outlines a framework for experiments with #organoids, #assembloids #transplantation from quality control and integrity

Our Giuseppe Testa group with colleagues from Università degli Studi di Milano developed "mosaic organoids", innovative models to study human brain development across multiple individuals simultaneously. A step closer to in vitro population studies. Published in nature Methods. humantechnopole.it/en/news/mosaic…

For a quick summary, read the Research Briefing on this work, here: nature.com/articles/s4159…

📢 Paper alert! Our paper on cortical brain organoids multiplexing is out Nature Methods. nature.com/articles/s4159… Together with the Research Briefing nature.com/articles/s4159… /1

Giuseppe Testa Nature Methods Congrats with this tour de force! This shows great promise for the mechanistic dissection of different neurodevelopmental disorders.

Sweet conclusion to 2024! It was a challenging but worthwhile journey in the Giuseppe Testa lab. Special thanks (and a big hug) to Nicolò Caporale, Marco Tullio Rigoli Carlo Emanuele Villa and Alessia for laying this new tile together in the brain organoids mosaic :) nature.com/articles/s4159…

1/2 pre-prints to end the year! Synthetic Physiology Lab is happy to present *CALIPERS: Cell cycle-Aware Live Imaging for Phenotyping Experiments and Regeneration Studies* led by @moisesdisante and in collaboration with the amazing Alessandro Bertero and Florian Jug labs biorxiv.org/content/10.110…

✌️The February issue of Nature Methods features on its cover the research of our Giuseppe Testa Group on mosaic organoids to study the brains of multiple patients simultaneously! 😉Read more about the research 👉 humantechnopole.it/en/news/mosaic…

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Thank you Sergiu P. Pasca for catalyzing such a timely community effort and now cheers to ever new heights for #neural #organoids and their biomedical impact

I'm happy to share our work on the neurodevelopmental impact of ADNP mutations in #ASD and beyond. It has been an exciting ride to share with Alessandro Vitriolo, Mariana, and the people of Giuseppe Testa and Raymond Poot Lab. Full paper here: biorxiv.org/content/10.110… Thread below 🧵

#neurogen25 kicking off the first Neurogenomics conference Human Technopole looking forward to 3 days of exciting science co-organized with Jose Davila Velderrain Harschnitz Nereo Kalebic elena taverna humantechnopole.it/it/trainings/n…

And we're back! Come to see our poster on how we are developing a platform to use brain patient-derived organoids at big scale to try to understand the neurological complications present in long covid at #neurogen25 ! Giuseppe Testa lab, part of NeuroCOV consortium

The peer-reviewed version of expansion in situ genome sequencing is now out in Science! The news is bittersweet – when we first revealed this last September, I never guessed it would be my final paper in academia, but a lot has changed. A few parting thoughts: