A biocatalytic route to C-nucleosides – acib acib.at/a-biocatalytic…

Is the substrate for your glycosyltransferase poorly soluble in water and DMSO is inactivating your enzyme? Find out how you can use cyclodextrins to solve the problem in our newest publication: pubs.acs.org/doi/10.1021/ac… NidetzkyLab TU Graz

🔍 Curious about the nuances between C- and O-glycoside elliminases? 🤔 Check our latest publication Springer Nature in Nature Communications from NidetzkyLab TU Graz nature.com/articles/s4146… #Enzymes #Biochemistry

Curious about advanced sucrose phosphorylase kinetics? Explore our latest publications to delve into nuanced insights and understand how kinetic models elevate multi-enzyme cascades. TU Graz NidetzkyLab #Kinetics #EnzymeCascades onlinelibrary.wiley.com/doi/10.1002/bi… onlinelibrary.wiley.com/doi/10.1002/bi…

"Dive into our new review on 'C-Ribosylating Enzymes in the (Bio)Synthesis of C-Nucleosides and Natural Products'! From antimicrobial compounds to mRNA vaccine building blocks, explore enzymes, mechanisms, and biocatalytic applications. ACS Catalysis pubs.acs.org/doi/10.1021/ac…

Microorganisms in the human gut utilise so-called beta-elimination to break down plant natural products and thus make them available to humans. Fruit and vegetables contain a variety of plant natural products such as flavonoids, which are said to have health-promoting

Ever considered using magnet-induced local heating to modulate enzyme activity? 🤔 Dive into our latest paper for insights and surprises: onlinelibrary.wiley.com/doi/10.1002/sm… #MagneticParticles @Tugraz

Exploring Mechanochemical Coupling in Cellulose-Degrading Nanomachines! Our study unveils the cellulosome as a Brownian ratchet, propelling on cellulose by coupling protein motions to hydrolysis. Deeper insights: pubs.acs.org/doi/10.1021/ac…

Our review titled” Bottom‐up Synthesized Glucan Materials: Opportunities from Applied Biocatalysis” is out! Discover how biocatalysis crafts precise D-glucan structures, paving the way for advanced material applications! onlinelibrary.wiley.com/doi/10.1002/ad…

Flexible only to become rigid, no contradiction in enzyme catalysis! Our new study captures the interplay of structural preorganization and conformational sampling in UDP-glucuronic acid 4-epimerase catalysis. Nature Communications TU Graz nature.com/articles/s4146…

Thrilled to share our latest work with colleagues from Innsbruck: An efficient synthetic route for accessing stable isotope labelled pseudouridine phosphoramidites, enabling precise RNA NMR spectroscopy. …mistry-europe.onlinelibrary.wiley.com/doi/10.1002/ch… TU Graz @uniinsbruck

Deciphering the sweet side of polyphenol natural products, reported by NidetzkyLab nature.com/articles/s4200…

Looking forward to share some of the research we are doing on magnetically responsive enzyme@HOF biocomposites: if you are interested, please join Session 2, today at 14:10! MOF2024 FalcaroGroup cdoonan NidetzkyLab DOI: 10.26434/chemrxiv-2024-p7159

Excited to share our latest research on bacterial glucoside metabolism through a conserved non-hydrolytic pathway! TU Graz Angewandte Chemie NidetzkyLab #Microbiology #EnzymeResearch #Glucosides onlinelibrary.wiley.com/doi/10.1002/an…

Enzyme Machinery for Bacterial Glucoside Metabolism through a Conserved Non-hydrolytic Pathway (Bernd Nidetzky and co-workers). NidetzkyLab, TU Graz. #OpenAccess onlinelibrary.wiley.com/doi/10.1002/an…

Electrochemically Induced Nanoscale Stirring Boosts Functional Immobilization of Flavocytochrome P450 BM3 on Nanoporous Gold Electrodes - Hengge - Small Methods - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/sm…

Excited to share our latest research: Phosphorylation-condensation cascade for biocatalytic synthesis of C-nucleosides: Chem Catalysis cell.com/chem-catalysis…

New paper out now in Angewandte Chemie! We present a chemoenzymatic route for synthesizing N¹-methylpseudouridine triphosphate — a key mRNA vaccine component. A step forward in efficient nucleotide synthesis. onlinelibrary.wiley.com/doi/10.1002/an… #RNA #mRNA #SynBio TU Graz

Computational enzyme design by catalytic motif scaffolding １．A new enzyme design method called Riff-Diff combines machine learning with atomistic modeling to scaffold catalytic motifs in de novo proteins. It achieves catalytic activities approaching those of laboratory-evolved

Human GDP-l-fucose synthase (GFS) catalyzes a three-step reaction: epimerization at C-3″/C-5″ and NADPH-dependent reduction at C-4″. Kinetic and structural studies reveal: product release (GDP-l-fucose) is the rate-limiting step, not catalysis. pubs.acs.org/doi/10.1021/ac…