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New work from our lab shows how pericyte loss during brain aging contributes to blood flow disruption and capillary rarefaction. A repair strategy to mitigate these effects exists (pericyte remodeling), but needs help in the aged brain. biorxiv.org/content/10.110…

🚨 Preprint alert 🚨! biorxiv.org/content/10.110… This is a big one for the lab, the first since we moved to Del Monte Institute for Neuroscience in 2020! Hard to find happiness in a world filled w/such insanity ... but this is a source of 😄😀😃. This is the work of Kelsey Zuk, superstar. (1/N)

Feeling saddened and frustrated that anyone has to waste an iota of energy arguing about overturning precedents already made that will serve to reduce our autonomy, dignity, freedom and agency over our own bodies. RGB said it best: #WhatSheSaid #RoeVWadeprotest #RoeVWade

Three weeks ago, I had a miscarriage. I was six weeks pregnant. I live in Texas, a state that has effectively banned abortions. A thread about what it is to cease to be pregnant in a state where abortions are banned:

This May #hottopic is an in vivo two-photon microscopy study providing novel foundational knowledge on Perivascular fibroblast organization, morphology and dynamics. here is the paper in open access! journals.sagepub.com/doi/full/10.11… #ISCBFM - iscbfm.org #JCBFMhome

Excited to share my first paper with Andy Shih out today in Frontiers - Neuroscience! A how-to on optical pericyte ablations.

To close this amazing week of two invited talks and my amazing mentee wining the best poster.Happy to share my first corresponding author manuscript.🎉 Couple years of investment to have this protocol refined! Now you all can take advantage of it. 🧠 spiedigitallibrary.org/journals/neuro…

Optical ablation of single #Pericyte in mouse brain 2PM Cranial window PDGFRβ-Cre:Ai14🐭 50 mW laser irradiation No exogenous photosensitizer needed A powerful method from Dr. Andy Shih lab Frontiers - Neuroscience 2022 Cara Nielson Andy Shih frontiersin.org/articles/10.33…

Hey SFN members, my colleagues Cara Nielson and @sosamariaj need 2 sponsoring members each to join the society. Would any of my neuroscience tweeps be willing to sponsor these excellent colleagues? TIA!

Extremely honored to have been selected as a Damon Runyon Fellow! I could not have done it without my mentor and amazing lab members, thanks everyone! Salk Institute The Chalasani Lab

EZ Clear and Lightsheet imaging together make visualizing and investigating whole eye vasculature possible. No more flat mounting! #EZClear #ZeissMicroscopy #lightsheet #OiVM #fluorescencemonday

Pericyte loss during Alzheimer's disease has been strongly linked to blood-brain barrier leakage. Our new data suggests that capillary flow deficits due to pericyte loss probably happen much earlier. Just published in Nature Communications nature.com/articles/s4146…

Had a fantastic time at the #cshlbbb meeting with Andy Shih and new friends! 🧠

If the #Neurovascular unit were a solar system, the Neurovasculome would be the galaxy. This Statement in Stroke AHA/ASA explores the #Neurovasculome, and recent efforts to chart the diversity of vascular structures and functions that support brain health. ahajournals.org/doi/abs/10.116…

In this review, we discuss exciting advances in deep imaging that can enhance our understanding of white matter degeneration in mouse models of #AlzheimersDisease and #dementia. ahajournals.org/doi/10.1161/ST…

Hot off the press Cell! 📰 Excited to share a significant portion of my PhD work and my first major publication. The skull's role in the neuroimmune axis has been a hot topic, and our study showcases its potential for future neuroimmune research & even clinics

Happy to share the latest preprint from the Andy Shih! Here we learned how focal capillary injury in the brain may broadly affect blood flow. These adventures wouldn’t have been possible without Cara Nielson and @sosamariaj by my side! biorxiv.org/content/10.110…

This mini review was a fun one for @sosamariaj and I where we dove into the mysteries of brain perivascular fibroblasts! Thank you to Andy Shih for guidance on this one! Please enjoy 😊! frontiersin.org/articles/10.33…

What makes cerebral white matter more vulnerable with age? In this mouse study, we show that large and rare venules are bottlenecks for blood flow in the white matter. Deep branches of these venules are constricted with age, leading to reduced blood flow. biorxiv.org/content/10.110…

I am thrilled to share that the Bonney Lab will be opening its doors come January CU Anschutz Medical Campus in the department of Anesthesiology! We will study perivascular pathology in cerebral small vessel disease using in vivo and ultrastructural imaging approaches.