Seeing is believing! A real "ball-and-chain", quite different from the Nav channels. Congrats to Crina and her team! Ball-and-chain inactivation in a calcium-gated potassium channel disq.us/t/3n0eaid

Cryo-EM (not ET) structure of NPC!!! Congratulations to Yigong and his remarkable team! disq.us/t/3nanmts

Preprint of our cryo-ET work showing the Luminal Ring, a novel structure of the gigantic NPC complex.

EM/ET 🤗💪💪

So proud of my amazing team molbio.princeton.edu/news/making-mo…

Truly honored! Thank you Blavatnik Awards

Our new work is finally out!🍻 Extended from previous results, graphene grids are applied to establish a convenient workflow for cryo-EM analysis of liposome-embedded MPs. So many thanks to Nieng and Xia! More to be explored when everything back to normal pnas.org/content/early/…

The Molecular Biology Dept Princeton MolBio at Princeton University invites applications for a tenure-track faculty position at the Assistant Professor level for cryo-EM/ET. Applications are accepted online at princeton.edu/acad-positions…. All materials must be received by 11/1/20.

This is the source of funding that FBI is charging my MIT colleague, Gang Chen, of going to length to hide. I found the place where he hid it—a place called internet.

Another interesting example of AI structure prediction aiding #cryoem structure solution. Here Nieng Yan Princeton MolBio and Chuangye Yan Tsinghua University use it to reveal fascinating insights into in-cell cholesterol sensing with a digitonin-bound SCAP/Insig-2 complex.

Congratulations to my former postdoc Jianping Wu on the landmark structure of CatSper (Catspermasome) rdcu.be/cnMyF

Finally, we captured a different conformation of a Cav channel -- the N-type Cav2.2 in complex with Ziconotide, a peptide painkiller. Very proud of my brilliant postdocs Shuai and Xia rdcu.be/cnVxR

First publication in the new year. Here is a free access to the full text of our review article before Feb 26 authors.elsevier.com/a/1eNXw3S6GfF7… Congratulations and thanks to my wonderful co-authors!

My first in-person meeting since March 2020. So nice to catch up with friends!

A perfect day in Banff⛷

Truly honored!

Finally, here is the structure of GLUT4! No nanobody, no antibody — Just a 12-TM SLC by Cryo-EM! Thanks to my incredible collaborator Chuangye Yan nature.com/articles/s4146…

Announcing 📣 the 2022 Blavatnik Regional Awards Honorees🏅! Congratulations! 👏👏👏 blavatnikawards.org/news/items/202… #NPAW2022 nationalpostdoc Daniel Brandenburg Brookhaven Lab Rosemary Cater, PhD Columbia University Columbia Medicine Simons Foundation 高帅 Princeton University Princeton University Research Nieng Yan @WHUni_Official