
Niko Klink
@nikolasklink
PhD candidate @Gerschlab at the CGC of the @MPImoph and @TU_Dortmund. Fascinated by drug discovery and all things Ubiquitin.
ID: 1567592999084761092
07-09-2022 19:18:16
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107 Followers
193 Following

📢New lab preprint: 2.05 A #cryoEM structure of UapA: unprecedented aspects of the elevator-type transport (incl. water, lipids) and regulatory roles of the N-tail. With Diallinas, Mikros labs. Kudos Georgie, the bio boi and all co-authors. Universität Münster #SoN biorxiv.org/content/10.110…








In this work, Alessio Ciulli, @dlzollman, and Centre for Targeted Protein Degradation design and validate a truncated CRBN construct, CRBNmidi, that enables crystallization and biophysical characterization of CRBN-binding ligands and degraders. #TPD #PROTAC nature.com/articles/s4146…


Looking for E3 / PROTAC / glue or DUB / DUBTAC substrates? Proxy-Ubiquitomics might be the way - applied here to USP30 Andreas Damianou Hannah Jones Oxford Discovery Proteomics biorxiv.org/cgi/content/sh… #biorxiv_molbio





Very excited to share that our manuscript on the "Discovery and mechanism of K63-linkage-directed deubiquitinase activity in USP53" was published today at Nature Chemical Biology Nature Chemical Biology. Congratulations Kim, Kai, and all authors! nature.com/articles/s4158…



Kicking off the new year properly: In collaboration between the labs of Giulio Superti-Furga and Alessio Ciulli we found that the efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells. Out in CellChemicalBiology cell.com/cell-chemical-…



New Parkinson’s disease paper: Chimeric deubiquitinase engineering reveals structural basis for specific inhibition of USP30 and a framework for DUB ligandability - published by Malte Gersch group Max Planck Society in nature Struct. & Mol. Biol. nature.com/articles/s4159…
