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📢New lab preprint: 2.05 A #cryoEM structure of UapA: unprecedented aspects of the elevator-type transport (incl. water, lipids) and regulatory roles of the N-tail. With Diallinas, Mikros labs. Kudos Georgie, the bio boi and all co-authors. Universität Münster #SoN biorxiv.org/content/10.110…

❗📚💡 PROTAC-DB 3.0: an updated database of PROTACs with extended pharmacokinetic parameters academic.oup.com/nar/advance-ar… #TPD #Targeted_Protein_Degradation

Our new paper demonstrating reversible ubiquitylation of DNA and RNA: embopress.org/doi/full/10.10…

Proud to share our work on this fascinating enzyme and inhibitor class, congrats to everyone involved! This story is definetly worth a read. Cant wait to hear Feedback on our DUB ligandability proposal aswell!

Honored to have presented my and our @Gerschlab research at this great conference! Looking forward to two more days!

Long non-coding RNA GRASLND links melanoma differentiation and interferon-gamma response - published by the Imig group in Frontiers Molecular Biosciences frontiersin.org/journals/molec…

We are excited to share our latest work in context of the colaborative research consortium 1430 CRC 1430. A preprint is available on bioRxiv (doi.org/10.1101/2024.1…).

We’re delighted to be partnering with @AlleoLabs to accelerate DUB-focused drug discovery! This collaboration will combine Alleo’s AI-based platform with our expertise in the DUB space to advance DUB-focused preclinical programmes. ➡ tinyurl.com/283d7o5o

In this work, Alessio Ciulli, @dlzollman, and Centre for Targeted Protein Degradation design and validate a truncated CRBN construct, CRBNmidi, that enables crystallization and biophysical characterization of CRBN-binding ligands and degraders. #TPD #PROTAC nature.com/articles/s4146…

Looking for E3 / PROTAC / glue or DUB / DUBTAC substrates? Proxy-Ubiquitomics might be the way - applied here to USP30 Andreas Damianou Hannah Jones Oxford Discovery Proteomics biorxiv.org/cgi/content/sh… #biorxiv_molbio

Caspase-2 is a condensate-mediated deubiquitinase in protein quality control: nature.com/articles/s4155…

I had such a great time at this years AEK autumn school on #degraders and bringing them towards clinical applications. Fantastic Talks from both academia and Industry. I learned alot, got to see old friends and made New ones. Im bringing home great memories and a bunch of notes!

“We’re very excited to see what people do with this” AlphaFold3 is open at last go.nature.com/4fHAfio

Tomorrow, November 26, we are looking forward to hosting @georg_e_winter from CeMM, Austrian Academy of Sciences, Vienna, at CRC 1430 Uni Duisburg-Essen @unidue.bsky.social. Join us for his exciting talk on small-molecule degraders!

Very excited to share that our manuscript on the "Discovery and mechanism of K63-linkage-directed deubiquitinase activity in USP53" was published today at Nature Chemical Biology Nature Chemical Biology. Congratulations Kim, Kai, and all authors! nature.com/articles/s4158…

Read how deubiquitinases USP53 and USP54 cleave long polyubiquitin chains and how the former is linked to liver disease in children. mpi-dortmund.mpg.de/news/new-enzym…

Kicking off the new year properly: In collaboration between the labs of Giulio Superti-Furga and Alessio Ciulli we found that the efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells. Out in CellChemicalBiology cell.com/cell-chemical-…

Fighting drug-resistant GIST!🚀 We developed innovative covalent KIT/PDGFRA inhibitors using structure-based design. Check out our latest J Med Chem publication! doi.org/10.1021/acs.jm… #CancerResearch #DrugDiscovery

New Parkinson’s disease paper: Chimeric deubiquitinase engineering reveals structural basis for specific inhibition of USP30 and a framework for DUB ligandability - published by Malte Gersch group Max Planck Society in nature Struct. & Mol. Biol. nature.com/articles/s4159…

Excited to share that our work on Parkinson's target USP30 has been published in Nature Structural & Molecular Biology! By combining DUB-domains onto USP30, we for the first time achieved crystallization with a small molecule (NK036) without Nanobodies! nature.com/articles/s4159…