Niko Klink (@nikolasklink) 's Twitter Profile
Niko Klink

@nikolasklink

PhD candidate @Gerschlab at the CGC of the @MPImoph and @TU_Dortmund. Fascinated by drug discovery and all things Ubiquitin.

ID: 1567592999084761092

calendar_today07-09-2022 19:18:16

130 Tweet

107 Followers

193 Following

Gatsogiannis Lab (@gatsogiannislab) 's Twitter Profile Photo

📢New lab preprint: 2.05 A #cryoEM structure of UapA: unprecedented aspects of the elevator-type transport (incl. water, lipids) and regulatory roles of the N-tail. With Diallinas, Mikros labs. Kudos Georgie, the bio boi and all co-authors. Universität Münster #SoN biorxiv.org/content/10.110…

Ziemowit_Pokladek (@zpokladek) 's Twitter Profile Photo

❗📚💡 PROTAC-DB 3.0: an updated database of PROTACs with extended pharmacokinetic parameters academic.oup.com/nar/advance-ar… #TPD #Targeted_Protein_Degradation

Niko Klink (@nikolasklink) 's Twitter Profile Photo

Proud to share our work on this fascinating enzyme and inhibitor class, congrats to everyone involved! This story is definetly worth a read. Cant wait to hear Feedback on our DUB ligandability proposal aswell!

MPI Dortmund (@mpimoph) 's Twitter Profile Photo

Long non-coding RNA GRASLND links melanoma differentiation and interferon-gamma response - published by the Imig group in Frontiers Molecular Biosciences frontiersin.org/journals/molec…

WestermannLab (@labwestermann) 's Twitter Profile Photo

We are excited to share our latest work in context of the colaborative research consortium 1430 CRC 1430. A preprint is available on bioRxiv (doi.org/10.1101/2024.1…).

Ubiquigent (@ubiquigent) 's Twitter Profile Photo

We’re delighted to be partnering with @AlleoLabs to accelerate DUB-focused drug discovery! This collaboration will combine Alleo’s AI-based platform with our expertise in the DUB space to advance DUB-focused preclinical programmes. ➡ tinyurl.com/283d7o5o

We’re delighted to be partnering with @AlleoLabs to accelerate DUB-focused drug discovery!

This collaboration will combine Alleo’s AI-based platform with our expertise in the DUB space to advance DUB-focused preclinical programmes.
➡ tinyurl.com/283d7o5o
Nature Communications (@naturecomms) 's Twitter Profile Photo

In this work, Alessio Ciulli, @dlzollman, and Centre for Targeted Protein Degradation design and validate a truncated CRBN construct, CRBNmidi, that enables crystallization and biophysical characterization of CRBN-binding ligands and degraders. #TPD #PROTAC nature.com/articles/s4146…

In this work, <a href="/alessiociulli/">Alessio Ciulli</a>, @dlzollman, and <a href="/UoDCeTPD/">Centre for Targeted Protein Degradation</a> design and validate a truncated CRBN construct, CRBNmidi, that enables crystallization and biophysical characterization of CRBN-binding ligands and degraders. #TPD #PROTAC

nature.com/articles/s4146…
Kessler Group Oxford (@kesslerlabox) 's Twitter Profile Photo

Looking for E3 / PROTAC / glue or DUB / DUBTAC substrates? Proxy-Ubiquitomics might be the way - applied here to USP30 Andreas Damianou Hannah Jones Oxford Discovery Proteomics biorxiv.org/cgi/content/sh… #biorxiv_molbio

Niko Klink (@nikolasklink) 's Twitter Profile Photo

I had such a great time at this years AEK autumn school on #degraders and bringing them towards clinical applications. Fantastic Talks from both academia and Industry. I learned alot, got to see old friends and made New ones. Im bringing home great memories and a bunch of notes!

I had such a great time at this years AEK autumn school on #degraders and bringing them towards clinical applications. Fantastic Talks from both academia and Industry. I learned alot, got to see old friends and made New ones. Im bringing home great memories and a bunch of notes!
CRC 1430 (@crc1430) 's Twitter Profile Photo

Tomorrow, November 26, we are looking forward to hosting @georg_e_winter from CeMM, Austrian Academy of Sciences, Vienna, at CRC 1430 Uni Duisburg-Essen @unidue.bsky.social. Join us for his exciting talk on small-molecule degraders!

Tomorrow, November 26, we are looking forward to hosting @georg_e_winter from <a href="/CeMM_News/">CeMM</a>, Austrian Academy of Sciences, Vienna, at <a href="/crc1430/">CRC 1430</a> <a href="/unidue/">Uni Duisburg-Essen @unidue.bsky.social</a>. Join us for his exciting talk on small-molecule degraders!
Malte Gersch (@maltegersch) 's Twitter Profile Photo

Very excited to share that our manuscript on the "Discovery and mechanism of K63-linkage-directed deubiquitinase activity in USP53" was published today at Nature Chemical Biology Nature Chemical Biology. Congratulations Kim, Kai, and all authors! nature.com/articles/s4158…

Very excited to share that our manuscript on the "Discovery and mechanism of K63-linkage-directed deubiquitinase activity in USP53" was published today at Nature Chemical Biology <a href="/nchembio/">Nature Chemical Biology</a>. Congratulations Kim, Kai, and all authors! nature.com/articles/s4158…
MPI Dortmund (@mpimoph) 's Twitter Profile Photo

Read how deubiquitinases USP53 and USP54 cleave long polyubiquitin chains and how the former is linked to liver disease in children. mpi-dortmund.mpg.de/news/new-enzym…

Superti-Furga Lab (@gsf_lab) 's Twitter Profile Photo

Kicking off the new year properly: In collaboration between the labs of Giulio Superti-Furga and Alessio Ciulli we found that the efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells. Out in CellChemicalBiology cell.com/cell-chemical-…

Kicking off the new year properly: In collaboration between the labs of <a href="/giuliosf/">Giulio Superti-Furga</a> and <a href="/alessiociulli/">Alessio Ciulli</a> we found that the efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells. Out in <a href="/CellChemBiol/">CellChemicalBiology</a> cell.com/cell-chemical-…
Drug Discovery Hub Dortmund (@ddhdortmund) 's Twitter Profile Photo

Fighting drug-resistant GIST!🚀 We developed innovative covalent KIT/PDGFRA inhibitors using structure-based design. Check out our latest J Med Chem publication! doi.org/10.1021/acs.jm… #CancerResearch #DrugDiscovery

Fighting drug-resistant GIST!🚀 We developed innovative covalent KIT/PDGFRA inhibitors using structure-based design. Check out our latest J Med Chem publication! doi.org/10.1021/acs.jm…

#CancerResearch #DrugDiscovery
MPI Dortmund (@mpimoph) 's Twitter Profile Photo

New Parkinson’s disease paper: Chimeric deubiquitinase engineering reveals structural basis for specific inhibition of USP30 and a framework for DUB ligandability - published by Malte Gersch group Max Planck Society in nature Struct. & Mol. Biol. nature.com/articles/s4159…

Niko Klink (@nikolasklink) 's Twitter Profile Photo

Excited to share that our work on Parkinson's target USP30 has been published in Nature Structural & Molecular Biology! By combining DUB-domains onto USP30, we for the first time achieved crystallization with a small molecule (NK036) without Nanobodies! nature.com/articles/s4159…