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Check out our newest work on J. Am. Chem. Soc.. The P411 enzymes were evolved to mediate direct primary amination of sp3 C-H bonds, unprecedented in nature and synthetic chemistry. pubs.acs.org/doi/10.1021/ja… Frances Arnold

It's out! This is what I mentioned today on the webinar. Great work by Zhijun Jia, Shilong Gao, and some amazing #enzymes. #directedevolution #biocatalysis #proteinengineering

Working with enzymes? Do you know what the measure 'katal' is? Find out here! Was a pleasure writing this piece Nature Physics. Frances Arnold Caltech Chemistry & Chemical Engineering nature.com/articles/s4156…

So excited to announce that my student Erin McCarthy has just received the Fred Wedler Outstanding Dissertation Award Penn State BMB, and my student Cody Lloyd just received the Paul Althouse Outstanding Teaching Assistant Award Penn State BMB Penn State Eberly College of Science. Very proud of these guys!!!

Excited to share our application of Transformers to generating functional signal peptides (SPs) with Kevin K. Yang 楊凱筌 Frances Arnold and a wonderful team at @basf coordinated by Michael Liszka. pubs.acs.org/doi/10.1021/ac…

My latest paper in ⁦ChemBioChem⁩ is now out. I can genuinely say that TrpB is such a fun enzyme to work with that I truly enjoyed writing this review to share my passion with the world! What can’t this enzyme do? ⁦⁦Frances Arnold⁩ doi.org/10.1002/cbic.2…

An Enzyme-Action-Movie, based on seven intermediate structures, is published in PNAS. Those familiar with our work should know we've gone through the distance to achieve this success (doi: 10.1073/pnas.2005327117). Congratulations to everyone who has contributed!

A new screening technology developed by Eberly's Brad Rogers, Paul Cremer, and Tinglu Yang of Penn State Chemistry works to better predict drugs' shelf life and stability — potentially reducing both time and financial costs in biological drug development. buff.ly/3bCtIWl

Congratulations to my awesome colleague Amie Boal (science.psu.edu/chem/people/ak…) Penn State Eberly College of Science Penn State BMB Penn State Chemistry who was announced as the 2021 winner of the ACS Pfizer Award in Enzyme Chemistry!!! Super highly deserved!!!

The perspective I wrote with my advisor, Frances Arnold, is out today in ACS Catalysis! We talk about native iron oxygenase mechanisms and then illustrate the abiological transformations made possible by engineering these platforms. Hope you enjoy! pubs.acs.org/doi/10.1021/ac…

Nature’s Machinery, Repurposed: Expanding the Repertoire of Iron-Dependent Oxygenases Noah Dunham Frances Arnold ow.ly/KXcP50Cao8h

Big congratulations to Dan Wise and Emma Gogarnoiu for their work on photoinduced alkene cleavage, a creative new alternative to an old reaction! pubs.acs.org/doi/10.1021/ja…

Thank you to everyone who came to my talk yesterday and for the great New Reactions & Methodology session! Looking forward to listening to some great talks this week! #ACSFall2022 #ACSChicago

Is this real life? 🥹

You just never know what to expect from an uninvited guest... #weddingcrasher #TRex #runforyourlife

Truly masterful talk by Emma Gogarnoiu on Synthesis Workshop's Synthesis Workshop featuring their recently published study in JACS (go.acs.org/1Yo). The chemistry is very creative, and they bolster it with a quite elegant mechanistic investigation. youtube.com/watch?v=M10DhM…

If adventure is calling, then check out my friend Prosper's new Mt. Kilimanjaro guiding company. He's an amazing guide, even got a tired crew like ours to the summit back in 2017! prosusclimbsandsafaris.com

Lysine an amine donor in transaminase-catalyzed reactions? A thrifty hack for driving equilibria! chemrxiv.org/engage/chemrxi…

Wild-type transaminases, a lysine smart donor, and a great scope of noncanonical amino acids, out today in J. Am. Chem. Soc. (pubs.acs.org/doi/10.1021/ja…). All thanks to a crack team! Steven Silverman, Matt Winston, RITWIKA RAY, Yining, Mikhail Reibarkh