🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

3rd mobile genetic element workshop in UK gonna happen on 15th-16th June! Wanna present your work? Wanna chat with lovely people? Wanna win the best Karaoke singer prize? Click the registration link below😉 Audience are ready in the front seats! ukmgeworkshop.org

1/8 Just launched: DeepMolecules – a webserver for predicting protein-small molecule interactions using AI, now out in Nucleic Acids Research! academic.oup.com/nar/advance-ar… DeepMolecules.org Heinrich-Heine-Universität Düsseldorf

Come join us in Southampton! You need to register to participate (free registration!). To give everyone an opportunity to showcase their science, we extended the deadline for title submission to May 16. Share widely!

Realfreq, a framework for real-time base modification analysis for nanopore sequencing, is now published in Bioinformatics. Written efficiently using C, a laptop can keep up with a Oxford Nanopore MinION sequencer, and a desktop a PromethION 2 solo flowcell. academic.oup.com/bioinformatics…

We’re excited to share new work on the continuous in vivo evolution of gene libraries towards arbitrary functions. Led by superstar Olek Pisera, our experiments show that gene evolution is highly versatile...biorxiv.org/content/10.110…

Want to find new lytic phages .... then obviously look in bacterial genomes !!! Led by Thomas Sicheritz-Pontén , with Martha Clokie Panos G. Kalatzis , Bent Petersen and many many others... biorxiv.org/content/10.110…

White smoke, we have not only a new pope, but also 16 new anti-phage systems in integrons ! In collaboration with the Didier Mazel lab, we show in our new paper that cassettes of these large platforms encode known anti-phage defenses and uncovered 16 new ones. science.org/doi/10.1126/sc…

How to find fantastic new #RNAs? The J2 antibody is the gold standard to detect, map & enrich dsRNAs. Co-led by Bou-Nader lab, Kevin Juma, Ankur Bothra & Steve Leppla’s lab, we visualize how J2 recognizes dsRNA and define its epitope, specificity & bias. doi.org/10.1101/2025.0….

1/6 🚀 Delighted to see our review out online in Nature Reviews Bioengineering: CRISPR–Cas therapies targeting bacteria. Read: doi.org/10.1038/s44222…

1/10 Today in Science Magazine in collaboration with liugroup we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells. drive.google.com/file/d/1I-UbCR…

We are looking for an ambitious and talented research fellow (lecturer level) to work on an exciting new synthetic genomics project. The research fellow will be encouraged to develop independent research lines complementary to the main project. jobs.manchester.ac.uk/Job/JobDetail?…

Come work with me, Martha Clokie ,Spyridon Megremis, PhD (he/him)🇬🇷🏀☘️🎧 in the Becky Mayer Centre for phage research on the isolation and genomes sequencing of 1000s of phages for a biobank. jobs.le.ac.uk/vacancies/vaca…

RareFold predicts and designs proteins with noncanonical AAs. With EvoBindRare, we designed linear & cyclic peptide binders with high affinity & novel binding modes, validated in wet lab. A step toward next-gen therapeutics. 📄 biorxiv.org/content/10.110… 💻 github.com/patrickbryant1…

One week left to register: ukmgeworkshop.org We still have space for additional attendees. Better program than your favourite paid conference - just saying 😉

Intra-phage immunity: Set a (pro)phage to catch a phage: Franklin Nobrega highlights work screening temperate phages for defenses against other temperate phages, uncovering an array of prophage-encoded immune systems in E. coli. cell.com/cell-host-micr…

New cryo-EM structures shine light on key steps in CRISPR-based adaptive immunity! Viral DNA induces a structural change in the Cas1-2/3 integrase needed for recruitment to the CRISPR. We capture how CRISPR repeat is unwound to allow complete integration! biorxiv.org/content/10.110…

Latest BREX story from the lab - turns out there is a nuclease after all! Congrats to Jenny Readshaw and the whole team, including wonderful collabs Barry Stoddard, Brett Kaiser and Darren Smith. Nucleic Acids Res New England Biolabs Durham BioSciences academic.oup.com/nar/article/53…

We’re excited to bring the phage-collection.org to #SummerScience at The Royal Society.org next week — showcasing our work on phage therapy and open science. Big thanks to James Gallagher for covering the project in the BBC News (UK). Read more here: bbc.com/news/articles/…

People are being invited to help find phages - tiny viruses that could hold the key to combating #AntibioticResistance. Our BRC’s Franklin Nobrega leads the project, which will be on display at the The Royal Society Summer Science Exhibition. Find out more: southamptonbrc.nihr.ac.uk/post/the-solut…

Can we use RNA to insert kilobases of DNA into the human genome, opening up a new way to engineer cells or treat disease? Excited to share our latest work turning a retrotransposon (a “jumping gene” with an RNA intermediate) from songbirds into a genome editing tool. 🧵 (1/7)