
Kridsadakorn Nook Prakinee
@nookkprakinee
Postdoctoral researcher and PhD in @pchaiyen group learning enzyme mechanisms and engineering
ID: 1164078523797004289
https://chaiyengroup.org 21-08-2019 07:35:31
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Delighted to share our latest research contribution in flow biocatalysis, published in Organic Process Research & Development ACS Publications! The work is also featured in "Flow Chemistry Enabling Efficient Synthesis 2024" special issue. 1/n pubs.acs.org/doi/full/10.10…


On the Mechanisms of Hypohalous Acid Formation and Electrophilic Halogenation by Non-Native Halogenases (Pimchai Chaiyen and co-workers) Pimchai Chaiyen VISTEC Kridsadakorn Nook Prakinee @Phintha_A #OpenAccess onlinelibrary.wiley.com/doi/10.1002/an…

My primary PhD project with Frances Arnold at Caltech is out now in Nature Chemical Biology! Here we show that the β-subunit of tryptophan synthase (TrpB) is a latent *tyrosine* synthase (TyrS), capable of regioselective and irreversible alkylation of phenols to tyrosines. Read more below:



Very happy to share our latest work showcasing a strategic design to perform efficient enzyme engineering with minimal experimental effort (performing mutagenesis of only 7 residues). Work by Sirus Kongjaroon and team tinyurl.com/m4frbm2

Big Thanks to our collaborators Pimchai Chaiyen Ma Guang-Lei Hoa Tran, Profs Li Jian, and Gao YG An Enzymatic Oxidation Cascade Converts δ-Thiolactone Anthracene to Anthraquinone in the Biosynthesis of Anthraquinone-Fused Enediynes | JACS Au pubs.acs.org/doi/abs/10.102…

Covalent flavoprotein oxidases are enzymes with great potential! Excited to share our latest review on the Biosynthetic Strategies of BBE-like #Flavoprotein #Oxidases and their role in natural product biosynthesis! 🌿🔬ACS Publications pubs.acs.org/doi/10.1021/ac…

Our latest perspective article by Kridsadakorn Nook Prakinee Suppalak Phaisan Sirus Kongjaroon on how to use Ancestral Sequence Reconstruction for enzyme engineering recently published in JACS Au. pubs.acs.org/doi/full/10.10…




Thanks Nature Chemical Biology for our opportunity to write Retrospective article on the landmark paper by Arnold's group. We all highly regard this paper for showcasing that directed evolution can enable enzymes to form silicon–carbon bonds, new-to-nature chemistry. doi.org/10.1038/s41589…





Happy to share our latest perspective on flavin-dependent halogenases. Kridsadakorn Nook Prakinee discussed reactions and mechanisms of recently discovered halogenases. We also discussed non-native halogenase scaffolds and expansion of halogenase biocatalytic scopes. doi.org/10.1002/cctc.2…

Our first publication on P450 enzymes led by Suppalak Phaisan has just been published. We identified and characterized a new CYP152 fatty acid decarboxylase from L. alkaliphilus. It has several unique structural characteristics. jbc.org/article/S0021-…