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Introducing mipDVP (multiplexed imaging-powered Deep Visual Proteomics)! Using 22-marker imaging to profile proteomes across hot/cold tumors, revealing immune microenvironments, macrophage barriers to T cells, & hypoxic adaptations. Out in Molecular Cell doi.org/10.1016/j.molc…

Previous post on lifesaving impact of this proteomic/ML approach erictopol.substack.com/p/the-dawn-of-…

News from the Matthias Mann Lab in Molecular Cell: Multiplexed imaging-powered Deep Visual Proteomics offers deeper insights into the tumor microenvironment by mapping 21 cell populations and quantifying thousands of proteins in each, revealing critical tumor-immune interactions. Huge

Our nature protocol on accessible high-sensitivity #PASEF #proteomics is featured on Nature homepage this week! Follow our workflow to reach 7k proteins & 29k phosphosites in 21min using dia-PASEF, synchro-PASEF & py_diAID. nature.com/nprot/ @PatiSkowronek #TeamMassSpec

We have now released 𝐃𝐈𝐀-𝐍𝐍 𝟐.𝟎! DIA-NN 2.0 Academia: lnkd.in/ehFF2Mf4. We also now offer DIA-NN Enterprise for Industry, please contact Aptila Biotech aptila.bio.

Interesting survey commented out in nature shows that researchers believe AI outperforms humans in 20+ research tasks. Sebastian Porsdam Mann University of Copenhagen notes: 'What really stands out is the imminence of this.' Research is just beginning to adapt. nature.com/articles/d4158…

Spatial transcriptomics methods have been slow to move into clinical practice, but spatial proteomics are cheaper and more scalable, and could progress faster go.nature.com/3PoWPkz rdcu.be/d9mWu

🥇 FEBS Letters is pleased to announce that the FEBS Letters Award 2025 will be presented to Prof. Peter Murray Peter J Murray (Immunoregulation Research Group, Max Planck Institute of Biochemistry (MPIB)) and Dr. Arno Alpi (Department of Molecular Machines and Signaling, Max Planck Institute of Biochemistry (MPIB), and Institute of Cell

Congratulations to Arno Alpi and Peter Murray for the FEBS Letters Award 2025. 🥳 Peter J Murray Arno Alpi

Thrilled to share our latest work published in Nature Genetics today: Plasma proteome variation and its genetic determinants in children and adolescents. 🩸#PediatricProteomics #PlasmaProteomics #pQTL nature.com/articles/s4158… 🧵A thread by Lili Niu explains below ⬇️

Check out our nature review with Tiannan Guo Guomics and Judith Steen Judith Steen on recent paradigm shifts in MS-based proteomics - where the field stands and where its headed. #Proteomics #AI nature.com/articles/s4158…

Put it on your calendar. This will be the best symposium yet!

Introducing #AlphaQuant: Our tree-based proteomics quantification detects up to 50X more protein regulation, scores accuracy, and clusters peptides to infer regulated proteoforms. github.com/MannLabs/alpha… biorxiv.org/content/10.110… A thread by Constantin Ammar explains below:

Our PCA-N method with neutralization step enables direct enzymatic digestion, doubles proteome depth from 5µL neat plasma, and scales to 10K+ sample preps/day. Democratizing plasma proteomics with validation across 50K measurements. On bioRxiv! biorxiv.org/content/10.110…

Our paper is out in nature today! We use Deep Visual Proteomics (DVP) to dissect α1-antitrypsin deficiency (AATD) in human liver at single-cell resolution. Let us take a tour through proteotoxic stress in intact human tissue — one hepatocyte at a time. nature.com/articles/s4158…

1/ Excited to share CellFlow, a new approach for complex perturbation modeling in single-cell genomics based on flow matching. From cytokine screens to cell fate and organoid engineering, we show CellFlow’s broad power across many diverse tasks. 👉 Paper: biorxiv.org/content/10.110…

Thrilled to share our new preprint! We developed mxDVP, a scalable spatial proteomics pipeline combining multiplexed 🔬 & ultra-sensitive MS to deeply profile pancreatic islets - revealing rare polyhormonal states. biorxiv.org/content/10.110… #SpatialOmics #SingleCell #SpatialBiology

Since April, Thierry Nordmann has been leading the Research Group "Molecular and Spatial Biology of the Skin" Max Planck Institute of Biochemistry (MPIB) He has now been awarded the prestigious Oscar Gans Prize by the German Dermatological Society. Congratulations and welcome! #OscarGansPrize Matthias Mann Lab

🎉Congrats to Thierry Nordmann, head of the “Molecular & Spatial Biology of the Skin” group Max Planck Institute of Biochemistry (MPIB) on winning the prestigious Oscar Gans Prize for his groundbreaking research in dermatology & spatial proteomics (DVP). 🔗 Read more: fcld.ly/wahp0le #OscarGansPrize

Today "a milestone in the evolution of personalized therapies for rare & ultra-rare inborn errors of metabolism" —the 1st human to undergo custom genome editing —outgrowth of decades of NIH funded research nejm.org/doi/full/10.10… nejm.org/doi/full/10.10… NEJM