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Proud to present my results @ #ACC2024 🫀 Elevated PEEP unloads the LV without compromising cardiac output in pigs with isolated LV dysfunction and untreated cardiogenic shock 🩺🐷 Department of Cardiology Research AUH Kristoffer Berg Hansen Nigopan Gopalasingam Mads Dam Lyhne

Butyrate elevates cardiac output via enhanced contractility and vasorelaxation and induces cardioprotection in rats. #AHAJournals Jacob Seefeldt Department of Cardiology Research AUH ahajrnls.org/4bjlRec

Astonishing presentation on #ketones in HF and type 2 diabetes by my co-supervisor Nigopan Gopalasingam who defended his PhD thesis today 🫀 Department of Cardiology Research AUH

🗣️ Excited to share our new study revealing the hemodynamic benefits of ketone ester treatment in patients with #HFpEF! 🫀 Circulation ahajournals.org/doi/10.1161/CI… Kristoffer Berg Hansen Kristian Christensen Bertil Ladefoged @bborlaugmd Mads J Andersen

Increasing #PEEP in AMI-CS unloads the LV without altering cardiac output or cardiac efficiency. PEEP could be a viable treatment option if titrated optimally during AMI-CS Now online ahead of print in Anesthesiology ⬇️ doi.org/10.1097/ALN.00… steffen christensen Kristoffer Berg Hansen

🔎LAST CALL FOR ONE-DAY SYMPOSIUM ON KETONES 🔎 The deadline for registration for the course on ketones and fasting is Sunday the 29th of September. 👉 Sign up here: shorturl.at/uz1JG

Now published before print in Anesthesiology 📄 Elevated PEEP unloads the LV in experimental AMI-CS🫀 Preclinical studies enable measurements often not feasible in clinical settings All results here ⬇️⬇️ doi.org/10.1097/ALN.00… #cardiogenicshock #hemodynamics

Now published in the December edition of Anesthesiology 📖❄️ Explore the hemodynamic effects of elevated PEEP in cardiogenic shock in the paper (link in post ⬇️⬇️) or visit the Anesthesiology podcast (December 2024 edition, about 9 mins in) 🎧🦻 anesthesiology.libsyn.com

In a large animal model of left ventricular cardiogenic shock, researchers investigated the cardiovascular effects of increasing positive end-expiratory pressure. Read the new study: ow.ly/JkK050UlRNQ

Proud to have my abstracts accepted for presentation at European Society of Cardiology Acute CardioVascular Care 2025 in Florence 🫀🚀 Looking forward to sharing my work in experimental #cardiogenicshock 🐷💔 Excited to contribute to the advancement of acute cardiovascular care - see you there(?)

In HFrEF patients, exogenous ketone body therapy improves cardiac function. But they have a short half life. Here we show prolonged ketosis and cardiac benefit with 1,3-butanediol in HFrEF patients🫀❤️‍🔥 Kristoffer Berg Hansen Oskar Hørsdal Nigopan Gopalasingam ahajournals.org/doi/10.1161/JA…

1,3‐butanediol improves cardiac function in heart failure patients, offering potential for sustained ketosis therapy. #AHAJournals Halvor Guldbrandsen Nigopan Gopalasingam Kristian Christensen Oskar Hørsdal Kristoffer Berg Hansen Department of Cardiology Research AUH ahajrnls.org/3EbE2qr

Happy to co-author this new paper 📝 In healthy pigs butyrate increases cardiac output and causes profound vasorelaxation at much lower concentrations than other short monocarboxylates 🫀💉 Interesting to see the effects in disease states 💊 Full text doi.org/10.1016/j.lfs.…

At European Society of Cardiology ACVC 2025 I will present the hemodynamic effects of infusion with lactate in a porcine model of #cardiogenicshock Meanwhile, take a look at the effects in healthy pigs and healthy volunteers 🫀 Lactate: friend or foe? doi.org/10.1186/s12967… doi.org/10.1186/s13054…

Proud to present the hemodynamic effects of lactate infusion in #cardiogenicshock at European Society of Cardiology #ACVC2025: Increased CO due to increased SV, enhanced ventriculo-arterial coupling and improved mitochondrial function 🫀 Full article published in Critical Care doi.org/10.1186/s13054…

Exciting experimental data from Alexander and Lasse from Department of Cardiology Research AUH presented today at European Society of Cardiology #ACVC2025 🫀 Ketone body 3-hydroxybutyrate may improve hemodynamics in #pulmonaryembolism Short chain fatty acid butyrate increases CO in healthy pigs (⬇️) doi.org/10.1016/j.lfs.…

If you haven’t done so already, head to Critical Care to read our latest experimental paper on the hemodynamic and cardiometabolic effects of #lactate infusion in #cardiogenicshock 🫀🐖 Rumors have it, that more exciting news are on the way 🤯 Stay tuned⁉️ rdcu.be/efEl5

Now published in Basic Research in Cardiology 📑🚀 Infusion with #ketones improves hemodynamics and preserves mitochondrial and contractile function and in ischemic #cardiogenicshock 🐷🫀 doi.org/10.1007/s00395…