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Bacterial droplet-based single-cell RNA-seq reveals antibiotic-associated heterogeneous cellular states Cell "BacDrop thus can capture cellular states that cannot be detected by bulk RNA-seq" #microbiology #microbiome #genomics #research cell.com/cell/fulltext/…

Great talks, posters, meetings at #ECCMID23 CANS - Centre for New Antibacterial Strategies Kristin Hegstad wasifa kabir Øyvind Myrvoll Lorentzen Ken Lindstedt Marit Hetland

Delighted to share our new preprint. It started with a weird observation, only made possible due to my ‘error’ while following a simple protocol. >10,000 swarm plates later, we show that intracellular iron can act as memory in E. coli. biorxiv.org/content/10.110… Thread 1/15

🚨 Preprint alert! Revealing the mechanisms of EPISTASIS in enzyme evolution (β-lactamase OXA-48). Mutations may be structurally orthogonal, but their combination exhibits powerful epistasis driving AMR. The key? Shifting the rate-limiting step! biorxiv.org/content/10.110…

Excited to share our latest study, now out in PLOS Pathogens. Using polarized renal proximal tubule epithelial cells (RPTECs), we characterized major steps of BKPyV's replication cycle to learn more about BKPyV dissemination and cytopathic effects. doi.org/10.1371/journa…

Great fun working with Christopher Frøhlich 🇪🇺🇳🇴🇨🇦🇩🇪🏳️‍🌈 on this!

Successful E. coli clones and plasmids? In our new work, we show that some plasmid types have coexisted for centuries with their hosts and confer them with traits important during pathogenesis and competition (colicins for the win!) biorxiv.org/content/10.110…

🌱Exciting News! Our AMR & Biofilms research just received an 8M kroner grant from #HelseNord. Big thanks for supporting young researchers and fueling scientific innovation. Grateful to all who've contributed to this success, especially Øyvind Myrvoll Lorentzen, @Paal_Johnsen and CANS - Centre for New Antibacterial Strategies.

🔬 Postdoc Opportunity UiT Norges arktiske universitet! Join our Arctic MSCA-PF program in Enzyme & AMR evolution. 🌌 24-months MSCA in Tromsø's stunning landscape. 📅 Apply by Feb 16: 3-page CV & 2-page proposal to [email protected]. #sciencejobs #postdocposition euraxess.ec.europa.eu/jobs/189491

Are you interested how #epistasis shapes the AMR evolution? We showed that epistasis can be caused by independently modulating substrate binding and the chemical step ultimately changing the rate-limiting step in the catalytic cycle. Nature Catalysis nature.com/articles/s4192…

The Biofilm Lifestyle Shapes the Evolution of β-Lactamases buff.ly/3TNvUlF Øyvind Myrvoll Lorentzen @Paal_Johnsen Christopher Frøhlich 🇪🇺🇳🇴🇨🇦🇩🇪🏳️‍🌈 #science #evolution #biology #genome

The feeling when your twin brother defends his PhD-thesis in splendid fashion! Read it here: munin.uit.no/handle/10037/3…

A comparative genomic and phenotypic study of Vibrio cholerae model strains using hybrid sequencing. Published #OpenAccess and fee-free in #MicrobioJ using a #PublishAndRead agreement: doi.org/10.1099/mic.0.…

Quite excited about the latest "Universal rules govern plasmid copy number", with my new group: Paula Ramiro Nacho de Quinto Cáceres & Jerónimo Rodríguez-Beltrán ! Have you given it a look yet? Check also the supporting work by Lingchong You & Co.

The last paper of my PhD is now out in PLOS Pathogens! BK Polyomavirus causes massive cytoplasmic vaculization in renal epithelial cells and this is likely caused by massive entry of BKPyV into endo-/lysosomes! #BKPyV doi.org/10.1371/journa…

Exciting times! Our latest preprint is now live 🤩! I truly believe this is one of the most significant contributions we've made. It offers fresh hypotheses about how pandemic Vibrio cholerae spreads globally. Let’s dive in!🧵..1/n biorxiv.org/content/10.110…

Tomorrow Øyvind Myrvoll Lorentzen is defending his PhD thesis Microbial evolution in biofilms! Information about the event: uit.no/tavla/artikkel… Thesis: munin.uit.no/handle/10037/3…