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New article online: Extreme waveform compression with a nonlinear temporal focusing mirror. go.nature.com/3Ue4r9X

Hyperfolder YFP (hfYFP) and its variants are remarkably stable, withstanding chaotropic conditions that denature other fluorescent proteins. They are well-suited for use in expansion microscopy and CLEM. Ben Campbell OA paper: nature.com/articles/s4159…

Anyone fancy of working with me on multisensory integration in the auditory system using state of the art techniques? Two PhD positions in my recently granted #VIDI project are still open for application: werkenbijerasmusmc.nl/en/vacancy/791… Erasmus MC Erasmus MC Intl

Out today! Radial Symmetry-FISH (RS-FISH) -- an accurate, fast, and user-friendly software for spot detection in 2D and 3D images. Bring on your smFISH, spatial transcriptomics, or spatial genomics applications! Kyle Harrington @successprocess @preibischs

Our latest work on #bioRxiv answers a simple question: can you see cellular substructures and ultrastructure without fluorescence, or even a 🔬? - Yes, you can! With #UnclearingMicroscopy! Ons M'Saad Michael Shribak Yale Cell Biology biorxiv.org/content/10.110…

Research highlight by Rita Strack An approach combining in situ tagmentation and transcription with MERFISH enables spatial profiling of the epigenome in tissues with single-cell resolution. Highlight: nature.com/articles/s4159… Paper: doi.org/10.1016/j.cell…

Introducing a foundational advance in imaging: "Any immersion remote refocus (AIRR) microscopy" Spoiler: Get aberration-free 3D imaging in a sample of any refractive index using an immersion objective of any type! All in one microscope! Article here: amsikking.github.io/any_immersion_…

Spatial-omics goes 3D🤗! Out at Cell Cell 👉🏼 We developed DISCO-MS with Matthias Mann Lab, a spatial proteomics technology for specimens fully imaged in 3D. DISCO-MS is aided by robotics and enables the study of diseases at their early stages. cell.com/cell/fulltext/…🧵👇

Nonnegative spatial factorization: a general framework for spatially-aware and interpretable dimension reduction for high-dimensional spatial data, and its application to spatial transcriptomics analysis. Barbara Engelhardt Will Townes OA paper: nature.com/articles/s4159…

It's finally here!! Our Method of the Year 2022 is....long-read sequencing! 🎉 Read our (free!) Editorial to learn why we felt the time was right to select this class of powerful technologies as the Method of the Year. nature.com/articles/s4159…

From Qing Nie and colleagues: a computational tool, COMMOT, spatially infers cell-cell communication from transcriptomics data. UCI Math nature.com/articles/s4159…

Need a long working distance (20 mm of air) objective for multiphoton imaging work? 0.5 NA, 3 mm wide field-of-view. Many people have already bought them. We're organizing another batch order. If you're interested, you can contact me. Preprint: biorxiv.org/content/10.110…

An unbiased study of whole biological systems is key to deciphering complexity. Our new paper describes the steps & applications of vDISCO whole mouse imaging in Nature Protocols work by Ruiyao Marika Cai, Ilgın Kolabas et al. #vDISCO #clearing nature.com/articles/s4159… 🧵👇1/n

Imagine you could stain whole adult mice with standard IgG antibodies. What you couldn't do! We present wildDISCO technology for this🤗, creating the first whole body vascular, lymphatic, and nerve atlases. By HongchengMAI Jie Luo biorxiv.org/content/10.110… 🧵👇🏼(turn on the sound)

I am glad that our new vDISCO article (nanobody labelling of whole mouse) made the cover of Nature Protocols😃. Work by Ruiyao Marika Cai Ilgın Kolabas and Chenchen Pan et al. doi.org/10.1038/s41596…

As reported in the Asahi Shinbun in March 1907, the crew of a British ship that arrived in Yokohama a few days prior claimed that they encountered a creature on the open sea just off the coast of Taiwan. The creature was about 15ft high and 200ft long with spikes on its back.

New content online: Broadband control of topological–spectral correlations in space–time beams. bit.ly/3qXVMip

A mind-blowing paper has come out today in nature In 2016, JC Venter Institute scientists trimmed a bacterial genome to its barest minimum required for life to synthesize what they called a "minimal genome" (science.org/doi/10.1126/sc…). Today, a group of scientists from

We are thrilled to present our new study unlocking precision in nanoparticles. Cell-level resolution imaging is key in targeted nanoparticle development. See our work on DNA Origami🧬: biorxiv.org/content/10.110… by Müge Molbay, Shan, Benni Kick et al, with @hendrik_dietz.🧵👇🏼

The slight disappointment with being scooped is more than compensated by the very nice results and demonstrations of reduced photobleaching/toxicity with NIR co-illumination in this paper by Ludvikova et al: doi.org/10.1038/s41587…