🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Excited to share our latest work and first venture into the chromatin field. We visualized for the first time that shelterin factor TRF1 binds and modulates telomeric nucleosome. hongmiao @AutomneNine Great collaboration with the Robinson's group science.org/doi/full/10.11…

We are excited to share our latest work on the cooperation between RNA polymerase and the ribosome in bacteria: science.org/doi/10.1126/sc… The work was supported by IGBMC, Inserm, CNRS 🌍, -, @ERC_research, IMCBio Graduate School, and Instruct-ERIC. 1/7

EMBL Group Leader Olivier Duss and his research team discovered how two molecular machines in bacteria work together and watched their interactions as a real-time movie. Read the full article to discover how they put snapshots in motion: embl.org/news/science-t…

Nature research paper: Tracking transcription–translation coupling in real time go.nature.com/3VLPiA7

Excited to share our new work on the earliest steps of Pol-III transcription: We provide structural and kinetic insights into tRNA promoter engagement by yeast transcription factor TFIIIC! Cool collaboration with the Müller and EustermannLab EMBL Details by the Wolfi below👇

Nature research paper: The mechanism of mRNA cap recognition go.nature.com/3ORbRzm

Are you looking forward to 2025 as much as we are? 👀 We just updated our 2025 EMBL Annual Poster to include even more courses and conferences for you to join, so go and have a look! ➡️ s.embl.org/poster-x #EMBLEvents #molecularbiology #lifesciencetraining

🔬 From cryo-EM to multi-scale modelling – what types of biological questions can be addressed using in situ structural biology? 📢 Last chance to register and join us in person for 'In situ structural biology: expanding the toolbox for structural cell biology' #EMBOinsitu 🧬🤩

Glad to be part of two new @nature papers led by Maximilia Degenhardt Yun-Tzai Cloud Lee Yun-Xing Wang Lab Ilias Skeparnias, which use AFM images and neural networks to map complex #RNA conformations and dynamics in solution. A Herculean effort! nature.com/articles/s4158…. & nature.com/articles/s4158….

Ever wondered how several individual RBPs cooperate to repress translation? To figure it out, we simultaneously tracked the binding of several proteins to single mRNA molecules in real-time! Lead by Marco Payr 🇺🇦 and great collaboration with Hennig lab! biorxiv.org/content/10.110…

The timeline of co-transcriptional #mRNA processing and #modification may have to be revised: cleavage, termination, and #m6A deposition may occur earlier than most #splicing! Potential textbook changing study by Eduardo Eyras & Hayashi labs! AJ Sethi biorxiv.org/content/10.110…

Online Now: Chromatin-bound U2AF2 splicing factor ensures exon inclusion dlvr.it/TKVRpb

Check out our recent article in collaboration with the Fan lab: The Bustamante Lab work led by Honglu Zhang in Science Advances! Congrats to all authors involved! Cristhian Cañari Chumpitaz science.org/doi/10.1126/sc…

Our #RNA multimer paper out now in @nature! #cryoEM of 2 distinct nanocages GOLLD and ROOL and membrane-associated OLE. Multimers at ultra-low concentrations, special covariance for cross-molecule kissing loops, and speculation on function nature.com/articles/s4158…. 1/2

You want to start tomography? Solve structures inside cells? Reach Nyquist😳? We have a website for you! tomoguide.github.io You'll find a tutorial on how to reconstruct tomograms, pick particles and do subtomo averaging, using different software! Hope it will be useful !

Now online! m6A alters ribosome dynamics to initiate mRNA degradation dlvr.it/TKcRnJ

Check out this tour de force study by Sangwoo Park and his incredible team of collaborators. Biophysical properties of single nucleosomes are responsible for A and B compartments in cell nucleus.

...and big thanks to Janet Iwasa for making this amazing video to illustrate the strand-sliding mechanism!

1/10 Today in Science Magazine in collaboration with liugroup we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells. drive.google.com/file/d/1I-UbCR…