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Exercise improves biomarkers of healthspan, but training enhances neuromuscular resilience for aging. Treadmill gains won’t translate if life demands multidimensional movement. Are you optimizing for adaptability or repetition?

Does more protein = more muscle? Siim Land & Matt Kaeberlein explore how lowering protein, while increasing fiber & carbs, led to muscle gains. The takeaway: optimal body composition isn’t about more, it’s about balance. Have you found your macro sweet spot?

How much protein do you really need to build muscle? Siim Land saw gains at just 0.6–0.7g/lb, confirmed by DEXA. The takeaway: more isn’t always better, quality matters.

Explore the breakthroughs driving the next chapter of aging at Longevity Summit Dublin From stem cell breakthroughs to AI-driven diagnostics and therapeutics, this summit brings bold science to life. 🎟️ July 2–4 | Trinity College Dublin 🔗 longevitysummitdublin.com/longevity-summ…

Between ages 62–78, you lose up to 98% of your ability to recognize new immune threats. It’s no coincidence mortality spikes then. How much could stronger immune resilience change how we age?

What do folks think about the two newest additions to the Hallmarks of Aging? I have to admit, when I first saw this, I checked to see if the paper came out on April 1.

Rapamycin: A drug that may slow aging with Matt Kaeberlein, PhD Matt Kaeberlein #aging #longevity youtube.com/watch?v=7VZEzX…

The Truth About Biological Age – What Really Slows Aging with Dr. Matt Kaeberlein Matt Kaeberlein #aging #longevity youtube.com/watch?v=-n7C5v…

Nice timing for the paper and this story to come out, as I had my first go at therapeutic plasma exchange this morning. Look at all that old man plasma they squeezed out of me 😅 In all seriousness, I'm very optimistic about this approach both for potential positive effects on

Why are people talking about TPE? instagram.com/p/DKLqjA4xBLC/

What's your favorite longevity myth? I'm starting a collection: instagram.com/p/DKX-GOwyKhk/

Today's longevity myth: FDA won't approve a drug that slows aging, because aging is not recognized as a disease. instagram.com/p/DKa6wFFxufJ/

The response from Matt Kaeberlein to a the question about NMN and why it's bad: "I wouldn't say NMN is necessarily "bad" although there is one study showing evidence that it causes kidney damage in aged animals. No data I'm aware of in humans on that. Leaving that risk out, there

Why does lifestyle impact so many different diseases?

Todays Longevity Myth: Aging research is adequately funded. instagram.com/p/DKcm4RYyl0v/ Thanks Anthony M. Hopper for the suggestion!

Today's Longevity Myth: Resveratrol is a longevity molecule You knew this one was coming, right? It's hard for me to believe how many people still think resveratrol is a longevity supplement. The scientific community moved on more than a decade ago, but some high profile

New episode of the Optispan Podcast just dropped. Microbiome expert Sean Gibbons from ISB sits down with me to decode the complex world of gut bacteria. Learn about good vs. bad bacteria, the impact of antibiotics and aging, and how diet and probiotics can influence your

Todays Longevity Myth: Your longevity is mostly determined by your genes. Less than 50% of longevity is inherited, and it's probably closer to 25% for most people. That means you have the power to greatly influence your own longevity and healthspan trajectory.

Why can't we do better than caloric restriction? From Matt Kaeberlein's talk at the NUS Gerophysics conference. Full video here: youtube.com/watch?v=hySlWn…

I need to update this with some new interventions, but the message will be the same. Other than CR, nothing is better than rapamycin for longevity (in mice) and nothing comes close to CR. Metformin, intermittent fasting, and nicotinamide riboside have lifespans essentially