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One of my imaging workhorses in the NET clinic, the CT enterography (CTE). Nothing better to visualize small NETs in the ileum. This patient has at least 30 small lesions that have been stable over many years and monitored with annual CTE. 50% or more of sbNETs are multifocal.

Nivolumab plus Ipilimumab in Microsatellite-Instability–High Metastatic Colorectal Cancer 2y PFS➡️72% vs 14% 💥When the right drug is given to the right patient at the right time, the survival curves can be as perfect as the one below👇 nejm.org/doi/full/10.10…

Genomic Alterations in DNA Mismatch Repair Genes Across Different Cancer Types JCO Precision Oncology doi.org/10.1200/PO-24-… ❓How do identify dMMR pts 👉33.8% pts with MMR mutations have MMR loss 👉only 34% of pts with MMR loss had MMR mutations 👉we need both NGS & IHC testing❗️ ESMO - Eur. Oncology

GI Oncology standard regimen doses remain too high for many real world patients. Retrospective and prospective trials demonstrating benefit of reduced doses or dose escalation are accumulating. #meded #gionc #crcsm #pancsm

Comparison of 1st chemotherapy in unresectable locally advanced or metastatic #PDAC The Lancet Oncology doi.org/10.1016/S1470-… 🔎systematic review & Bayesian network meta-analysis, 79 trials, 22 168 pts 👉NALIRIFOX & FOLFIRINOX may be the preferred options if feasible ESMO - Eur. Oncology

🔥ACRO ROVER- Upper GI🔥 Localized Esophagus Adenocarcinoma in 5 minutes, Check it out! ACROresident ACRO - American College of Radiation Oncology ROVERRO ARRO Mayo Clinic Radiation Oncology Dr. Nina Niu Sanford 1/

HCC 101! For the longest time, HCC was a bit of a blackbox to me. So for today’s ROVER presentation, I started off with a 5-slide summary of HCC basics: a 20,000 foot overview. Sharing here. Short thread 🧵 1/6.

#GI25 More about the immunotherapy BOT/BAL.🙌🏽 ✔️Neoadjuvant: 1️⃣🪺NEST➡️BOT/BAL 2️⃣🦄 UNICORN➡️BOT➕/➖BAL ✔️Metastatic: Dr. Marwan G. Fakih City of Hope 3️⃣BOT➕/➖BAL ➕Combinations 4️⃣FOLFOX-3B (BEV+BOT+BAL) 5️⃣iNKT🔵+RAM+TAX+ BOT+BAL Colorectal Cancer Alliance 2024 Advancements OncoAlert ASCO #CRCSM

✳️”Low sugar diet” question comes up in daily practice frequently as it is believed that “sugar feeds cancer”❗️ ✳️It is so important to differentiate “cancer prevention” and “treatment of advanced stage cancer” and they are highly different process; with distinct molecular &

We are excited to share a few upcoming live events in 2025 that we are moderating to discuss the current SoC, new data, conference highlights and board prep! 📅 Jan 24 #GI25 AIO, San Fran ✅ Register: bit.ly/aiogi25 📅 Feb 12 #GU25 AIO, San Fran ✅ Register:

#GI25 an option for our patients with #BRAFV600E🧬 mutant colorectal cancer. Median OS not reached 🆚 14 months in the standard of care. HR=0.47! OncoAlert Chemo➕targeted therapy frontline. Both response rates & OS are meaningful.

Masterclass presentation on the management of advanced colorectal cancer from Tanios Bekaii-Saab, MD at the inaugural Mayo Clinic Heme/Onc Board Review and Practice Update conference this week. Can he fit it in one slide...? He sure can! Don't miss this next year. tinyurl.com/rh7c927c

Hematologic dysfunction and myeloid neoplasm risk in patients treated with lutetium-177 prostate specific membrane antigen therapy pubmed.ncbi.nlm.nih.gov/40176753/ #Lutetium #CH #PPM1D #TP53 #prostate yael kusne MD PhD Mayo Clinic Comprehensive Cancer Center

🚨 Hot off the press! 🚨 The ESMO - Eur. Oncology Precision Oncology Working Group, led by the amazing Ben Westphalen G Curigliano MD PhD has unveiled key "Recommendations for structuring Molecular Tumour Boards (MTBs) in clinical practice", now published in ESMO's flagship journal Annals of Oncology

I know it has probably made its way into clinical practice (at least it has for me), but Ipi-Nivo now has FDA approval based on CheckMate8HW for dMMR mCRC! Excited to have this for our patients! Key Points: Ipi (1mg/kg) + Nivo (240mg) Q3W for 4 cycles then Nivo alone Massive

Trying to summarize nuanced treatment decisions in one slide... What to do with small NF-pNETs? Who to observe? When to intervene...? What am I missing/getting wrong...? Paging my surgery friends Julie Hallet Stefano Partelli Callisia Clarke MD Patrick Starlinger_TELL International Cornelius A. Thiels Sean Cleary

🦓 NANETS is going to LA ⭐️🍿🎥 If you’re around and want to learn more about #NETs, join us! I’ll be there along with Thor Halfdanarson Callisia Clarke MD Jess Maxwell MD MBA Laleh Melstrom & many more 📆 May 17 🔗 nanets.net/component/civi… Thanks Alexandra Gangi, MD for organizing!

Big week for #GIcancers, Nivo + Ipi gets FDA approved for HCC #livercancer, just a few days after the same regimen got approval in MSI-H #coloncancer. #CheckMate9DW ascopubs.org/doi/10.1200/JC… #Chekmate8HW nejm.org/doi/full/10.10… OncoAlert Oncology Brothers OncLive.com GI Oncology Now

Revolution Medicines Announces FDA Breakthrough Therapy Designation for Daraxonrasib in Previously Treated Metastatic Pancreatic Cancer with KRAS G12 Mutations | Revolution Medicines #ESMOGI25 ir.revmed.com/news-releases/…

Wishing you all the best! Mohamed Ali