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Let’s play a little game. Let’s say that you’re the CSO at a cancer pharma company, and you have to choose a target to go after. Here’s a gene – high expression is associated with poor prognosis in brain cancer. Looks like a good candidate for an inhibitor right?

There's still time to apply for this role in the Fratta lab, based at the Crick Institute / UCL, working on an exciting new gene therapy for ALS! jobs.ac.uk/job/DGS907/res…

A selection of our TDP-REG vectors are now available on Addgene! addgene.org/browse/article…

From computational models of the splicing code to regulatory mechanisms and therapeutic implications go.nature.com/4gPju63 #Review by Charlotte Capitanchik 🌙, Oscar Wilkins, Nils Wagner, Julien gagneurlab & Jernej ule_lab Helmholtz Munich | @HelmholtzMunich TU München The Francis Crick Institute King's College London

Brilliant to see our researchers publishing exciting new research! With #MND #ALS gene therapies taking center stage at the moment, this approach could open up more options for their development.

One of the UK’s largest philanthropic foundations, @SRausingTrust has extended support for the Neurogenetic Therapies Programme at UCL Queen Square Institute of Neurology until 2029, enabling researchers to further advance treatments for #neurodegenerative diseases.  bit.ly/3BSkeXX

Thrilled to share our latest manuscript on smOOPs, a highly interconnected class of condensation-prone mRNAs with signs of coordinated regulation, encoding functionally related proteins. Shoutout to the incredible team Ira Iosub, Jona & Tajda Klobucar. shorturl.at/EaSxD

I’m thrilled to share that our paper “Machine-guided design of cell-type-targeting cis-regulatory elements” was published online in nature. nature.com/articles/s4158… #genomics #MachineLearning #SyntheticBiology #bioengineering 1/9

New biopharmaceutical company Trace Neuroscience, co-founded by UCL Queen Square Institute of Neurology's Prof. Pietro Fratta (FrattaLab) has received >£78 million to develop potential treatment for motor neurone disease. 1/3 Read more ➡️ bit.ly/3O8Bk6Q