PALACE Trial
@palace_trial
The PALACE is an international, multicenter randomized control trial using the PEN-FAST tool to risk-stratify penicillin allergy labels in adult outpatients.
ID: 1532447986999087105
02-06-2022 19:44:43
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Wow! ๐ฅThe PALACE RCT ๐ฅ Jason Trubiano ๐ et Al JAMA Internal Medicine Direct oral penicillin challenge in patients with a low-risk penicillin allergy was noninferior compared with standard-of-care skin testing followed by oral challenge Thanks Ignacio uman jamanetwork.com/journals/jamaiโฆ
After an amazing 24 hrs and a lot of #IDtwitter ๐ฉท I thought I would provide my thoughts on our PALACE Trial in JAMA Internal Medicine and how we got here! Direct oral challenge (DOC) vs. skin testing + oral challenge (SOC) for low-risk #penicillinallergy jamanetwork.com/journals/jamaiโฆ 1/4
If a patient had a mild reaction to penicillin/amoxicillin longer than 5 years ago or any mild reaction that did not require treatment, clinicians can skip the allergy evaluation and perform the challenge themselves.Jason Trubiano ๐ Centre for Antibiotic Allergy & Research Allergy Immunology MUHC @vumc_cdsi_rsch Duke Antimicrobial Stewardship
Thanks NEJM Journal Watch for the review of the PALACE Trial in JAMA Internal Medicine - #PENFAST #penicillinallergy #DOC Infectious Diseases at Austin Health Doherty Institute UniMelb MDHS
Super proud of the team led by Kyra Chua @Jamie_L_Waldron Centre for Antibiotic Allergy & Research Infectious Diseases at Austin Health for this pilot work bringing #penicillinallergy #oralchallenge #DOC to #generalpractice RACGP. ๐ โก๏ธ jaci-inpractice.org/article/S2213-โฆ
โPenicillin Allergy Evaluation Should Be Performed Proactively in Patients with a Penicillin Allergy Label โ A Position Statement of AAAAI Cc Ana Copaescu Jason Trubiano ๐ Eric Macy Kimberly Blumenthal, MD, MSc #PALACE #IDXposts aaaai.org/Aaaai/media/Meโฆ
Whatโs Hot This Year in ID Clinical Science | Clinical Infectious Diseases | Great to ๐ the โฆPALACE Trialโฉ in the list โค๏ธ Thanks to authors & โฆClinical Infectious Diseasesโฉ ๐ #penicillinallergy #PENFAST in ID practice โ academic.oup.com/cid/advance-arโฆ
Joe De Luca PREPARE RCT results! Perioperative #penicillinallergy assessment via digital assessment safe! Your heard the results here 1st at #AAAAI24 ๐ Centre for Antibiotic Allergy & Research Infectious Diseases at Austin Health UniMelb MDHS
Ana Copaescu #AAAAI24 PALACE Trial Follow up resultsโฆ. 93% believe not allergic at 6m with 38% tolerating a treatment course. Infectious Diseases at Austin Health Centre for Antibiotic Allergy & Research Doherty Institute
The PALACE Trial: Rethinking How to Assess, Document, and Code New Penicillin Allergies: ยซย This is a call to action for primary care.ย ยป Kevin Fernando medscape.com/viewarticle/10โฆ
So exciting ๐ - Inpatient ๐ #penicillinallergy #delabeling data from 30 sites and 4 countries to date that will inform #drugallergy and #AMS practice from ๐ฆ๐บ, ๐ฌ๐ง, ๐ฟ๐ฆ, ๐ฒ๐พ and more to come shortlyโฆ (spoiler alert ๐ฆซ, ๐ฝ, ๐ฅโฆ.). Reach out to join us Centre for Antibiotic Allergy & Research Elise Mitri ๐ซต
๐๏ธ๐ฅCohort study following 20โฏ092 adult patients for up to 12 years Documented ฮฒ-lactam allergies were associated with increased odds of antibiotic-resistant infections, including MRSA, VRE, and the pooled odds of infection with MRSA,VRE,& C difficile. jamanetwork.com/journals/jamanโฆ
The PALACE Trial study has demonstrated that single-dose DOC in low-risk patients reporting a penicillin allergy is safe and effective at immediate (5 days) and prolonged follow-up (6 months). ja.ma/4fLY4pN Ana Copaescu Allergy Immunology MUHC Jason Trubiano ๐ Centre for Antibiotic Allergy & Research
Don't miss out on #DHS2024 Doherty Institute !! ๐จBreaking news Centre for Antibiotic Allergy & Research ๐จ โก๏ธ> 10 New #drugallergy Data Abstracts โก๏ธ New data on the latest member of the #PENFAST "family" โก๏ธLaunch of a National Antibiotic Allergy Network Inpatient Penicillin Allergy Guide in #AMS โก๏ธLaunch of new Antibiotic Allergy